Detail Information

Basic Information:


  VIRBase ID:  

HHID00060154

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:           TMF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p TMF1
miRBase
Accession/Entrez ID		 MIMAT0003150 7110
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ARA160//TMF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMF1
chr3:69076374(-) A-I      intronic
chr3:69076373(-) A-I      intronic
chr3:69076363(-) A-I      intronic
chr3:69076411(-) A-I      intronic
chr3:69076351(-) A-I      intronic
chr3:69076348(-) A-I      intronic
chr3:69076303(-) A-I      intronic
chr3:69076295(-) A-I      intronic
chr3:69076284(-) A-I      intronic
chr3:69076223(-) A-I      intronic
chr3:69075752(-) A-I      intronic
chr3:69075719(-) A-I      intronic
chr3:69075668(-) A-I      intronic
chr3:69075635(-) A-I      intronic
chr3:69075603(-) A-I      intronic
chr3:69075599(-) A-I      intronic
chr3:69075598(-) A-I      intronic
chr3:69075585(-) A-I      intronic
chr3:69075582(-) A-I      intronic
chr3:69075575(-) A-I      intronic
chr3:69075531(-) A-I      intronic
chr3:69075503(-) A-I      intronic
chr3:69081925(-) A-I      intronic
chr3:69075556(-) A-I      intronic
chr3:69091483(-) A-I      intronic
chr3:69091416(-) A-I      intronic
chr3:69091403(-) A-I      intronic
chr3:69091402(-) A-I      intronic
chr3:69088446(-) A-I      intronic
chr3:69088401(-) A-I      intronic
chr3:69086618(-) A-I      intronic
chr3:69083237(-) A-I      intronic
chr3:69083210(-) A-I      intronic
chr3:69083206(-) A-I      intronic
chr3:69082411(-) A-I      intronic
chr3:69082362(-) A-I      intronic
chr3:69082303(-) A-I      intronic
chr3:69082034(-) A-I      intronic
chr3:69081867(-) A-I      intronic
chr3:69081847(-) A-I      intronic
chr3:69076438(-) A-I      intronic
chr3:69076419(-) A-I      intronic
chr3:69075681(-) A-I      intronic
chr3:69076405(-) A-I      intronic
chr3:69076393(-) A-I      intronic
chr3:69071039(-) A-I      3'UTR
chr3:69070899(-) A-I      3'UTR
chr3:69071045(-) A-I      3'UTR
chr3:69070900(-) A-I      3'UTR
chr3:69070996(-) A-I      3'UTR
chr3:69071027(-) A-I      3'UTR
chr3:69071000(-) A-I      3'UTR
chr3:69071014(-) A-I      3'UTR
chr3:69071025(-) A-I      3'UTR
chr3:69071054(-) A-I      3'UTR
chr3:69071005(-) A-I      3'UTR
chr3:69070999(-) A-I      3'UTR
chr3:69071001(-) A-I      3'UTR
chr3:69071062(-) A-I      3'UTR
chr3:69071002(-) A-I      3'UTR
chr3:69083239(-) A-I      intronic
chr3:69081898(-) A-I      intronic
chr3:69075680(-) A-I      intronic
chr3:69100514(-) A-I      intronic
chr3:69076311(-) A-I      intronic
chr3:69070910(-) A-I      3'UTR
chr3:69070943(-) A-I      3'UTR
chr3:69070970(-) A-I      3'UTR
chr3:69070907(-) A-I      3'UTR
chr3:69075560(-) A-I      intronic
chr3:69076426(-) A-I      intronic
chr3:69075555(-) A-I      intronic
chr3:69082058(-) A-I      intronic
chr3:69081899(-) A-I      intronic
chr3:69076350(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMF1
chr3:69070904(-) A-I exon 3'UTR    15258596
chr3:69070907(-) A-I exon 3'UTR    15258596
chr3:69070910(-) A-I exon 3'UTR    15258596
chr3:69070943(-) A-I exon 3'UTR    15258596
chr3:69070960(-) A-I exon 3'UTR    15258596
chr3:69070969(-) A-I exon 3'UTR    15258596
chr3:69070970(-) A-I exon 3'UTR    15258596

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMF1
chr3:69069061-69069062(-) m6A 3'UTR       27773535
chr3:69069104-69069105(-) m6A 3'UTR       27773535
chr3:69069113-69069114(-) m6A 3'UTR       27773535
chr3:69070317-69070318(-) m6A 3'UTR       27773535
chr3:69070335-69070336(-) m6A 3'UTR       27773535
chr3:69070349-69070350(-) m6A 3'UTR       27773535
chr3:69072124-69072125(-) m6A 3'UTR       27773535
chr3:69072138-69072139(-) m6A 3'UTR       27773535
chr3:69072262-69072263(-) m6A 3'UTR       24981863//27773535//22608085
chr3:69072275-69072276(-) m6A 3'UTR       24981863//27773535//22608085
chr3:69072301-69072302(-) m6A 3'UTR       24981863//27773535//22608085
chr3:69072342-69072343(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr3:69072351-69072352(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr3:69072365-69072366(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69072405-69072406(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073216-69073217(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073223-69073224(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073253-69073254(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073283-69073284(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073306-69073307(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22608085
chr3:69073507-69073508(-) m6A exon//intron       24981863//27773535
chr3:69073542-69073543(-) m6A exon//intron       24981863
chr3:69074759-69074760(-) m6A 3'UTR//CDS//exon       24981863
chr3:69077064-69077065(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69077098-69077099(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69077402-69077403(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69077425-69077426(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69078971-69078972(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69078985-69078986(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69079034-69079035(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69079042-69079043(-) m6A 3'UTR//CDS       24981863//27773535
chr3:69079099-69079100(-) m6A CDS       27773535
chr3:69079146-69079147(-) m6A CDS//intron       27773535
chr3:69082743-69082744(-) m6A CDS//intron       24981863//27773535//27371828
chr3:69082792-69082793(-) m6A CDS//intron       24981863//27773535//27371828
chr3:69082822-69082823(-) m6A CDS//intron       24981863//27773535//27371828
chr3:69082829-69082830(-) m6A CDS//intron       24981863//27773535//27371828
chr3:69082852-69082853(-) m6A CDS//intron       24981863//27773535
chr3:69084182-69084183(-) m6A CDS       24981863//27773535
chr3:69084230-69084231(-) m6A CDS       24981863//27773535
chr3:69084258-69084259(-) m6A CDS       24981863//27773535
chr3:69087728-69087729(-) m6A CDS       27773535
chr3:69087780-69087781(-) m6A CDS       27773535
chr3:69087867-69087868(-) m6A CDS       27773535
chr3:69088029-69088030(-) m6A CDS       27773535
chr3:69088043-69088044(-) m6A CDS       27773535
chr3:69088053-69088054(-) m6A CDS       27773535
chr3:69088106-69088107(-) m6A CDS       24981863//28052920//27773535//22608085
chr3:69088130-69088131(-) m6A CDS       24981863//28052920//27773535//22608085
chr3:69088704-69088705(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr3:69088747-69088748(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr3:69088780-69088781(-) m6A CDS       24981863//27773535//22575960//22608085
chr3:69088827-69088828(-) m6A CDS       24981863//27773535//22575960
chr3:69088836-69088837(-) m6A CDS       24981863//27773535//22575960
chr3:69092004-69092005(-) m6A CDS       24981863//27773535//22575960
chr3:69092011-69092012(-) m6A CDS       24981863//27773535//22575960
chr3:69092039-69092040(-) m6A CDS       24981863//27773535
chr3:69092052-69092053(-) m6A CDS       24981863//27773535
chr3:69093745-69093746(-) m6A CDS//exon       24284625//25456834//24981863//27773535//22608085
chr3:69096559-69096560(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:69096581-69096582(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:69096595-69096596(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:69096637-69096638(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr3:69096708-69096709(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr3:69096750-69096751(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr3:69096875-69096876(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:69096919-69096920(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:69096984-69096985(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr3:69097020-69097021(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:69097027-69097028(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:69097148-69097149(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr3:69097156-69097157(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr3:69097162-69097163(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr3:69097171-69097172(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr3:69097184-69097185(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr3:69097191-69097192(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr3:69097242-69097243(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr3:69097317-69097318(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097338-69097339(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097368-69097369(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097394-69097395(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097416-69097417(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097425-69097426(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr3:69097504-69097505(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr3:69097533-69097534(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr3:69097593-69097594(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr3:69097648-69097649(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr3:69097655-69097656(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22608085
chr3:69101343-69101344(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TMF1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: TMF1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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