Basic Information:

  VIRBase ID:  

HHID00060150

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:  MIMAT0003150          DDX3X:  NR_126094     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-455-5p	DDX3X
miRBase Accession/Entrez ID	MIMAT0003150	1654
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAP-Rf//DBX//DDX14//DDX3//HLP2//MRX102//MRXSSB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-455-5p	rs1288139869 chr9:114209467    A/G rs1414847416 chr9:114209466    C/T rs552585852 chr9:114209470    G/A rs552585852 chr9:114209470    G/T rs776650840 chr9:114209469    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX3X	chrX:41200368(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX3X	chrX:41192893-41192894(+) m6A 5'UTR//exon       24981863 chrX:41192928-41192929(+) m6A 5'UTR//exon       24981863//27773535 chrX:41192942-41192943(+) m1A 5'UTR//exon       26863196 chrX:41192973-41192974(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41192979-41192980(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41193134-41193135(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193148-41193149(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193191-41193192(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193197-41193198(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193229-41193230(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193247-41193248(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193274-41193275(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193453-41193454(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960//22608085 chrX:41193478-41193479(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chrX:41193542-41193543(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chrX:41193982-41193983(+) m6A exon//intron       24981863 chrX:41196673-41196674(+) m6A CDS//exon       24284625//24981863 chrX:41196679-41196680(+) m6A CDS//exon       24284625//24981863 chrX:41198318-41198319(+) m6A CDS//exon//intron       24981863//26404942 chrX:41200751-41200752(+) m6A CDS//exon       24981863//26404942//22575960 chrX:41201833-41201834(+) m6A CDS//exon//intron       22575960 chrX:41201876-41201877(+) m6A CDS//exon//intron       22575960 chrX:41201903-41201904(+) m6A CDS//exon//intron       22575960 chrX:41201992-41201993(+) m6A CDS//exon//intron       22575960 chrX:41202505-41202506(+) m6A CDS//exon//intron       26404942//22575960 chrX:41203308-41203309(+) m6A CDS//exon//intron       22575960 chrX:41203561-41203562(+) m6A CDS//exon//intron       22575960 chrX:41203642-41203643(+) m6A CDS//exon//intron       22575960 chrX:41204504-41204505(+) m6A CDS//exon//intron       22575960 chrX:41206226-41206227(+) m6A CDS//intron       26404942 chrX:41206596-41206597(+) m6A CDS//intron       24209618//26404942//22575960 chrX:41207001-41207002(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207017-41207018(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207037-41207038(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207061-41207062(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207144-41207145(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207179-41207180(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207231-41207232(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207296-41207297(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535 chrX:41207373-41207374(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207390-41207391(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207459-41207460(+) m6A 3'UTR//intron       26404942 chrX:41207512-41207513(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207562-41207563(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207986-41207987(+) m6A 3'UTR//intron       22575960 chrX:41208065-41208066(+) m6A 3'UTR//intron       22575960 chrX:41208946-41208947(+) m6A 3'UTR//intron       27773535 chrX:41208968-41208969(+) m6A 3'UTR//intron       27773535 chrX:41209013-41209014(+) m6A 3'UTR//intron       27773535 chrX:41209081-41209082(+) m6A 3'UTR//intron       27773535 chrX:41209091-41209092(+) m6A 3'UTR//intron       27773535 chrX:41209199-41209200(+) m6A 3'UTR//intron       27773535 chrX:41209327-41209328(+) m6A 3'UTR//intron       27773535 chrX:41209349-41209350(+) m6A 3'UTR//intron       27773535 chrX:41209451-41209452(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-455-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DDX3X	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-455-5p	4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive CID 9604911 9604911 Drug sensitive 7-Hydroxystaurosporine 72271 Drug sensitive 5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive Chalcone analog 6296717 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant Antibiotic 1907-VIII 5477807 Drug resistant 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant Simvastatin 54454 Drug sensitive Lovastatin 53232 Drug sensitive N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant Latrunculin a 445420 Drug sensitive Trichopolyn 431962 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive Thiosangivamycin 3580213 Drug resistant Dasatinib 3062316 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive 5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug resistant Antineoplastic-633273 15954131 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive Berberine chloride 12456 Drug resistant p-Toluquinone 11122 Drug resistant 15,16-Dihydrocuracin A 101683509 Drug resistant 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant dichlorobisoxinatotitanium(iv) - Drug resistant leucinostatine d - Drug resistant n-acetyl-4-s-cystaminyl phenol - Drug resistant tetra(isobutenyl)antimony bromide - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive (-)-furodysinin - Drug sensitive geldanamycin dimethylglycinate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-455-5p	Gemcitabine 60750 Drug interaction    RC00005824 Vincristine 5978 Drug interaction    RC00005821 Prednisone 5865 Drug interaction    RC00005820 Temozolomide 5394 Drug interaction    RC00005819 Etoposide 36462 Drug interaction    RC00005823 5-Fluorouracil 3385 Drug interaction    RC00005818 Doxorubicin 31703 Drug interaction    RC00005822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817 Verapamil 2520 Drug interaction    RC00005816 Docetaxel 148124 Drug interaction    RC00005826 Methotrexate 126941 Drug interaction    RC00005825

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-455-5p	Cisplatin 5702198       21575166 5-Fluorouracil 3385       25356050

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-455-5p	Panobinostat       6918837 Irinotecan       60838 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-455-5p
Interactor2: DDX3X

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.