Detail Information

Basic Information:


  VIRBase ID:  

HHID00060144

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-18a-3p:           SNX5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-18a-3p SNX5
miRBase
Accession/Entrez ID		 MIMAT0002891 27131
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-18a-3p
rs772872341 chr13:91350818    G/C
rs1172339251 chr13:91350802    C/T
rs1340056222 chr13:91350803    C/CTAAG
rs1476796118 chr13:91350801    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SNX5
chr20:17943155(-) A-I      intronic
chr20:17937967(-) A-I      intronic
chr20:17943156(-) A-I      intronic
chr20:17935493(-) A-I      intronic
chr20:17937890(-) A-I      intronic
chr20:17937886(-) A-I      intronic
chr20:17937854(-) A-I      intronic
chr20:17937237(-) A-I      intronic
chr20:17937233(-) A-I      intronic
chr20:17941142(-) A-I      intronic
chr20:17941080(-) A-I      intronic
chr20:17937908(-) A-I      intronic
chr20:17937200(-) A-I      intronic
chr20:17943113(-) A-I      intronic
chr20:17941069(-) A-I      intronic
chr20:17937935(-) A-I      intronic
chr20:17941237(-) A-I      intronic
chr20:17937921(-) A-I      intronic
chr20:17937207(-) A-I      intronic
chr20:17937915(-) A-I      intronic
chr20:17936564(-) A-I      intronic
chr20:17944680(-) A-I      intronic
chr20:17943986(-) A-I      intronic
chr20:17942980(-) A-I      intronic
chr20:17943041(-) A-I      intronic
chr20:17935444(-) A-I      intronic
chr20:17941308(-) A-I      intronic
chr20:17941115(-) A-I      intronic
chr20:17935440(-) A-I      intronic
chr20:17940982(-) A-I      intronic
chr20:17941175(-) A-I      intronic
chr20:17936702(-) A-I      intronic
chr20:17943075(-) A-I      intronic
chr20:17936700(-) A-I      intronic
chr20:17941071(-) A-I      intronic
chr20:17943110(-) A-I      intronic
chr20:17944110(-) A-I      intronic
chr20:17935607(-) A-I      intronic
chr20:17942938(-) A-I      intronic
chr20:17943127(-) A-I      intronic
chr20:17943993(-) A-I      intronic
chr20:17935428(-) A-I      intronic
chr20:17943119(-) A-I      intronic
chr20:17937821(-) A-I      intronic
chr20:17938048(-) A-I      intronic
chr20:17943088(-) A-I      intronic
chr20:17944032(-) A-I      intronic
chr20:17937311(-) A-I      intronic
chr20:17936591(-) A-I      intronic
chr20:17946989(-) A-I      intronic
chr20:17941298(-) A-I      intronic
chr20:17940860(-) A-I      intronic
chr20:17937957(-) A-I      intronic
chr20:17936535(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SNX5
chr20:17942985(-) A-I intron -    15258596   //22327324
chr20:17943041(-) A-I intron -    15258596
chr20:17943068(-) A-I intron -    15258596
chr20:17943088(-) A-I intron -    15258596
chr20:17943118(-) A-I intron -    15258596
chr20:17943119(-) A-I intron -    15258596
chr20:17943121(-) A-I intron -    15258596
chr20:17942976(-) A-I intron -    22327324
chr20:17942986(-) A-I intron -    22327324
chr20:17938048(-) A-G intron -    22484847
chr20:17941175(-) A-G intron -    22484847
chr20:17942938(-) A-G intron -    22484847
chr20:17942980(-) A-G intron -    22484847
chr20:17942985(-) A-G intron -    22484847
chr20:17943118(-) A-G intron -    22484847
chr20:17943119(-) A-G intron -    22484847
chr20:17943121(-) A-G intron -    22484847
chr20:17943127(-) A-G intron -    22484847
chr20:17947044(-) A-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SNX5
chr20:17923762-17923763(-) m6A CDS//exon       24981863
chr20:17923774-17923775(-) m6A CDS//exon       24981863
chr20:17923837-17923838(-) m6A CDS//exon       24981863
chr20:17925285-17925286(-) m6A exon//intron       24981863
chr20:17928047-17928048(-) m6A 3'UTR//intron       24981863
chr20:17928078-17928079(-) m6A 3'UTR//intron       24981863
chr20:17928118-17928119(-) m6A 3'UTR//intron       24981863
chr20:17928154-17928155(-) m6A CDS//exon       24981863
chr20:17943465-17943466(-) Tm intron       -
chr20:17948415-17948416(-) m6A 3'UTR//intron       27773535
chr20:17948453-17948454(-) m6A 3'UTR//intron       27773535
chr20:17948537-17948538(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr20:17948567-17948568(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr20:17948590-17948591(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr20:17948648-17948649(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948708-17948709(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948730-17948731(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948753-17948754(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948788-17948789(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948802-17948803(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948807-17948808(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:17948885-17948886(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr20:17948995-17948996(-) m6A CDS//intron       27773536//22575960
chr20:17949027-17949028(-) m6A CDS//exon//intron       27773536
chr20:17949290-17949291(-) m6A 5'UTR//exon//intron       24209618//25456834//27371828//27773536//22575960//22608085
chr20:17949431-17949432(-) Y 5'UTR//exon       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-18a-3p
Cytoplasm Breast cancer tissue     32370743
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
SNX5
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-18a-3p
Enoxacin 3229 Drug interaction    RC00005791
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-18a-3p
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-18a-3p
Interactor2: SNX5

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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