Detail Information

Basic Information:


  VIRBase ID:  

HHID00060142

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-18a-3p:           RAB11FIP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-18a-3p RAB11FIP2
miRBase
Accession/Entrez ID		 MIMAT0002891 22841
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - nRip11//Rab11-FIP2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-18a-3p
rs772872341 chr13:91350818    G/C
rs1172339251 chr13:91350802    C/T
rs1340056222 chr13:91350803    C/CTAAG
rs1476796118 chr13:91350801    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAB11FIP2
chr10:119776622(-) A-I      intronic
chr10:119776638(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAB11FIP2
chr10:119765259-119765260(-) m6A 3'UTR       24981863
chr10:119765266-119765267(-) m6A 3'UTR//exon       24981863
chr10:119765376-119765377(-) m6A 3'UTR//intron       24981863//27773535
chr10:119765396-119765397(-) m6A 3'UTR//intron       27773535
chr10:119765407-119765408(-) m6A 3'UTR//intron       27773535
chr10:119767400-119767401(-) m6A 3'UTR//intron       24981863
chr10:119767411-119767412(-) m6A 3'UTR//intron       24981863
chr10:119768259-119768260(-) m6A 3'UTR//intron       27773535
chr10:119768351-119768352(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr10:119768424-119768425(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr10:119768441-119768442(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr10:119768477-119768478(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr10:119768544-119768545(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119768611-119768612(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119768619-119768620(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119768635-119768636(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119768652-119768653(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119768661-119768662(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119774591-119774592(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119798554-119798555(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr10:119798625-119798626(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr10:119798724-119798725(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119798749-119798750(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119798756-119798757(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr10:119798850-119798851(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr10:119798896-119798897(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr10:119798924-119798925(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:119799648-119799649(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119799670-119799671(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119799684-119799685(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119799709-119799710(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119799799-119799800(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr10:119799894-119799895(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:119799951-119799952(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr10:119799956-119799957(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr10:119799995-119799996(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr10:119800034-119800035(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr10:119800054-119800055(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr10:119805325-119805326(-) m6A CDS       24284625//24981863//27773535//22608085
chr10:119805342-119805343(-) m6A CDS       24981863//27773535//22608085
chr10:119805866-119805867(-) m6A 5'UTR       24284625
chr10:119805947-119805948(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-18a-3p
Cytoplasm Breast cancer tissue     32370743
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
RAB11FIP2
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-18a-3p
Enoxacin 3229 Drug interaction    RC00005791
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-18a-3p
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-18a-3p
Interactor2: RAB11FIP2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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