Basic Information:

  VIRBase ID:  

HHID00060140

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-18a-3p:  MIMAT0002891          UBA1:  NM_003334     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-18a-3p	UBA1
miRBase Accession/Entrez ID	MIMAT0002891	7317
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	A1S9//A1S9T//A1ST//AMCX1//CFAP124//GXP1//POC20//SMAX2//UBA1A//UBE1//UBE1X//VEXAS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-18a-3p	rs772872341 chr13:91350818    G/C rs1172339251 chr13:91350802    C/T rs1340056222 chr13:91350803    C/CTAAG rs1476796118 chr13:91350801    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBA1	chrX:47052179(+) A-I      intronic chrX:47067692(+) A-I      intronic chrX:47067670(+) A-I      intronic chrX:47063356(+) A-I      intronic chrX:47063326(+) A-I      intronic chrX:47067772(+) A-I      intronic chrX:47063277(+) A-I      intronic chrX:47067784(+) A-I      intronic chrX:47067837(+) A-I      intronic chrX:47063228(+) A-I      intronic chrX:47063399(+) A-I      intronic chrX:47067643(+) A-I      intronic chrX:47067845(+) A-I      intronic chrX:47063248(+) A-I      intronic chrX:47067575(+) A-I      intronic chrX:47063421(+) A-I      intronic chrX:47067585(+) A-I      intronic chrX:47067825(+) A-I      intronic chrX:47063321(+) A-I      intronic chrX:47063409(+) A-I      intronic chrX:47067815(+) A-I      intronic chrX:47063293(+) A-I      intronic chrX:47063225(+) A-I      intronic chrX:47067798(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBA1	chrX:47068232(+) A-I intron -    15342557   //15258596 chrX:47068234(+) A-I intron -    15342557   //15258596 chrX:47068235(+) A-I intron -    15342557   //15258596 chrX:47068287(+) A-I intron -    15342557   //15258596 chrX:47068298(+) A-I intron -    15342557   //15258596 chrX:47068307(+) A-I intron -    15342557   //15258596 chrX:47068577(+) A-I intron -    15342557   //15258596 chrX:47068579(+) A-I intron -    15342557   //15258596 chrX:47068692(+) A-I intron -    15342557   //15258596 chrX:47068694(+) A-I intron -    15342557   //15258596 chrX:47068714(+) A-I intron -    15342557   //15258596 chrX:47068753(+) A-I intron -    15342557   //15258596 chrX:47068762(+) A-I intron -    15342557   //15258596 chrX:47068805(+) A-I intron -    15342557   //15258596 chrX:47067783(+) A-I intron -    21960545 chrX:47068298(+) A-G intron -    21725310   //22484847 chrX:47068579(+) A-G intron -    21725310   //22484847 chrX:47068256(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBA1	chrX:47050824-47050825(+) m6A 5'UTR//intron       24284625//24981863//22575960 chrX:47050832-47050833(+) m6A 5'UTR//intron       24284625//22575960 chrX:47050837-47050838(+) m6A 5'UTR//intron       24284625//22575960 chrX:47050898-47050899(+) m6A 5'UTR//intron       24284625 chrX:47053266-47053267(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chrX:47053413-47053414(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960 chrX:47056626-47056627(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960 chrX:47058474-47058475(+) m6A CDS       22575960 chrX:47058699-47058700(+) m6A CDS       22575960 chrX:47061802-47061803(+) m6A CDS       22575960 chrX:47062050-47062051(+) m6A CDS       22575960 chrX:47062411-47062412(+) m6A CDS//exon       22575960 chrX:47062432-47062433(+) m6A CDS//exon       22575960 chrX:47062539-47062540(+) m6A CDS//exon       22575960 chrX:47062575-47062576(+) m6A CDS//exon       22575960 chrX:47062976-47062977(+) m6A CDS//exon       26404942//22575960 chrX:47063030-47063031(+) m6A CDS//exon       26404942//22575960 chrX:47063036-47063037(+) m6A CDS//exon       26404942//22575960 chrX:47064416-47064417(+) m6A intron       27773535 chrX:47064425-47064426(+) m6A intron       27773535 chrX:47064430-47064431(+) m6A intron       27773535 chrX:47064509-47064510(+) m6A intron       27773535 chrX:47064527-47064528(+) m6A intron       27773535 chrX:47064779-47064780(+) m6A intron       - chrX:47065419-47065420(+) m6A CDS//intron       22575960 chrX:47065470-47065471(+) m6A CDS//intron       22575960 chrX:47065497-47065498(+) m6A CDS//exon       22575960 chrX:47065658-47065659(+) m6A CDS//exon       22575960 chrX:47065772-47065773(+) m6A CDS//exon       26404942//27773535//22575960 chrX:47065811-47065812(+) m6A CDS//exon       26404942//27773535 chrX:47069328-47069329(+) m6A CDS       22575960 chrX:47069348-47069349(+) m6A CDS       22575960 chrX:47069426-47069427(+) m6A CDS       22575960 chrX:47069481-47069482(+) m6A CDS       22575960 chrX:47070447-47070448(+) m6A CDS       22575960 chrX:47070482-47070483(+) m6A CDS       22575960 chrX:47070507-47070508(+) m6A CDS       22575960 chrX:47071867-47071868(+) m6A CDS       22575960 chrX:47072230-47072231(+) m6A CDS       22575960 chrX:47072251-47072252(+) m6A CDS       22575960 chrX:47072555-47072556(+) m6A CDS       22575960 chrX:47074460-47074461(+) m6A 3'UTR       24284625//24981863//27773535 chrX:47074494-47074495(+) m6A 3'UTR       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-18a-3p	Cytoplasm Breast cancer tissue     32370743 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary ovarian tumor cells|Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	UBA1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-18a-3p	Enoxacin 3229 Drug interaction    RC00005791

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-18a-3p	Cisplatin 5702198       25356050 5-Fluorouracil 3385       25356050 Cetuximab -       26107137

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-18a-3p
Interactor2: UBA1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.