Basic Information:

  VIRBase ID:  

HHID00060133

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-18a-3p:  MIMAT0002891          CSNK1D:  NR_110578     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-18a-3p	CSNK1D
miRBase Accession/Entrez ID	MIMAT0002891	1453
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASPS//CKI-delta//CKId//CKIdelta//FASPS2//HCKID

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-18a-3p	rs772872341 chr13:91350818    G/C rs1172339251 chr13:91350802    C/T rs1340056222 chr13:91350803    C/CTAAG rs1476796118 chr13:91350801    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CSNK1D	chr17:80226887(-) A-I      intronic chr17:80214245(-) A-I      intronic chr17:80214240(-) A-I      intronic chr17:80214218(-) A-I      intronic chr17:80229128(-) A-I      intronic chr17:80229112(-) A-I      intronic chr17:80218848(-) A-I      intronic chr17:80214289(-) A-I      intronic chr17:80214241(-) A-I      intronic chr17:80229122(-) A-I      intronic chr17:80215935(-) A-I      intronic chr17:80215939(-) A-I      intronic chr17:80214974(-) A-I      intronic chr17:80214960(-) A-I      intronic chr17:80215951(-) A-I      intronic chr17:80222878(-) A-I      intronic chr17:80223219(-) A-I      intronic chr17:80223230(-) A-I      intronic chr17:80223234(-) A-I      intronic chr17:80226838(-) A-I      intronic chr17:80226916(-) A-I      intronic chr17:80229012(-) A-I      intronic chr17:80214933(-) A-I      intronic chr17:80214353(-) A-I      intronic chr17:80214307(-) A-I      intronic chr17:80230144(-) A-I      intronic chr17:80214306(-) A-I      intronic chr17:80214267(-) A-I      intronic chr17:80214222(-) A-I      intronic chr17:80214216(-) A-I      intronic chr17:80214199(-) A-I      intronic chr17:80214169(-) A-I      intronic chr17:80214152(-) A-I      intronic chr17:80214215(-) A-I      intronic chr17:80229020(-) A-I      intronic chr17:80229084(-) A-I      intronic chr17:80229146(-) A-I      intronic chr17:80229218(-) A-I      intronic chr17:80229227(-) A-I      intronic chr17:80230051(-) A-I      intronic chr17:80230055(-) A-I      intronic chr17:80230096(-) A-I      intronic chr17:80230120(-) A-I      intronic chr17:80230138(-) A-I      intronic chr17:80215955(-) A-I      intronic chr17:80220956(-) A-I      intronic chr17:80215988(-) A-I      intronic chr17:80216000(-) A-I      intronic chr17:80216033(-) A-I      intronic chr17:80216037(-) A-I      intronic chr17:80216069(-) A-I      intronic chr17:80220811(-) A-I      intronic chr17:80220813(-) A-I      intronic chr17:80220826(-) A-I      intronic chr17:80220839(-) A-I      intronic chr17:80220873(-) A-I      intronic chr17:80220890(-) A-I      intronic chr17:80222785(-) A-I      intronic chr17:80220944(-) A-I      intronic chr17:80221010(-) A-I      intronic chr17:80221042(-) A-I      intronic chr17:80222714(-) A-I      intronic chr17:80222872(-) A-I      intronic chr17:80222876(-) A-I      intronic chr17:80215876(-) A-I      intronic chr17:80230108(-) A-I      intronic chr17:80223140(-) A-I      intronic chr17:80223336(-) A-I      intronic chr17:80222737(-) A-I      intronic chr17:80229201(-) A-I      intronic chr17:80226809(-) A-I      intronic chr17:80230058(-) A-I      intronic chr17:80226910(-) A-I      intronic chr17:80220851(-) A-I      intronic chr17:80229090(-) A-I      intronic chr17:80218887(-) A-I      intronic chr17:80222871(-) A-I      intronic chr17:80223254(-) A-I      intronic chr17:80224824(-) A-I      intronic chr17:80226807(-) A-I      intronic chr17:80229028(-) A-I      intronic chr17:80223319(-) A-I      intronic chr17:80230064(-) A-I      intronic chr17:80223192(-) A-I      intronic chr17:80226735(-) A-I      intronic chr17:80220799(-) A-I      intronic chr17:80226851(-) A-I      intronic chr17:80229089(-) A-I      intronic chr17:80214136(-) A-I      intronic chr17:80229048(-) A-I      intronic chr17:80224680(-) A-I      intronic chr17:80223214(-) A-I      intronic chr17:80224692(-) A-I      intronic chr17:80229165(-) A-I      intronic chr17:80221050(-) A-I      intronic chr17:80224827(-) A-I      intronic chr17:80229121(-) A-I      intronic chr17:80229147(-) A-I      intronic chr17:80229155(-) A-I      intronic chr17:80223223(-) A-I      intronic chr17:80226890(-) A-I      intronic chr17:80222746(-) A-I      intronic chr17:80223117(-) A-I      intronic chr17:80230181(-) A-I      intronic chr17:80222812(-) A-I      intronic chr17:80229125(-) A-I      intronic chr17:80226966(-) A-I      intronic chr17:80220974(-) A-I      intronic chr17:80223193(-) A-I      intronic chr17:80230098(-) A-I      intronic chr17:80222948(-) A-I      intronic chr17:80214175(-) A-I      intronic chr17:80226790(-) A-I      intronic chr17:80226921(-) A-I      intronic chr17:80229019(-) A-I      intronic chr17:80229014(-) A-I      intronic chr17:80230072(-) A-I      intronic chr17:80223231(-) A-I      intronic chr17:80230002(-) A-I      intronic chr17:80222947(-) A-I      intronic chr17:80222870(-) A-I      intronic chr17:80223166(-) A-I      intronic chr17:80224814(-) A-I      intronic chr17:80229140(-) A-I      intronic chr17:80226804(-) A-I      intronic chr17:80223282(-) A-I      intronic chr17:80229057(-) A-I      intronic chr17:80229049(-) A-I      intronic chr17:80216036(-) A-I      intronic chr17:80229219(-) A-I      intronic chr17:80229154(-) A-I      intronic chr17:80226752(-) A-I      intronic chr17:80226972(-) A-I      intronic chr17:80226713(-) A-I      intronic chr17:80226813(-) A-I      intronic chr17:80226861(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CSNK1D	chr17:80223166(-) A-I intron -    15258596 chr17:80223192(-) A-I intron -    15258596 chr17:80223223(-) A-I intron -    15258596 chr17:80226713(-) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CSNK1D	chr17:80196994-80196995(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr17:80197634-80197635(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr17:80197721-80197722(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//27773536 chr17:80197734-80197735(-) m6A 3'UTR//intron       25456834//27371828//27773536 chr17:80197768-80197769(-) m6A 3'UTR//intron       25456834//27773536 chr17:80197927-80197928(-) m6A CDS       - chr17:80200894-80200895(-) m6A 3'UTR//exon//intron       24284625//22575960 chr17:80201086-80201087(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22575960 chr17:80201172-80201173(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22575960 chr17:80201203-80201204(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr17:80201477-80201478(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:80201484-80201485(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:80201527-80201528(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:80201558-80201559(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:80201592-80201593(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:80201712-80201713(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:80201719-80201720(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:80201777-80201778(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:80201788-80201789(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:80201901-80201902(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960//22608085 chr17:80201931-80201932(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr17:80201998-80201999(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr17:80202166-80202167(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr17:80202290-80202291(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr17:80202383-80202384(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:80202438-80202439(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:80202490-80202491(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:80202503-80202504(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:80202627-80202628(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:80202653-80202654(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960 chr17:80202823-80202824(-) m6A exon//intron       24284625//27773535//22575960 chr17:80203897-80203898(-) m6A 3'UTR//CDS//exon//intron       27773535 chr17:80203985-80203986(-) m6A exon//intron       27371828//27773536 chr17:80204014-80204015(-) m6A exon//intron       27371828//27773536 chr17:80204502-80204503(-) m6A exon//intron       - chr17:80204568-80204569(-) m6A exon//intron       - chr17:80204653-80204654(-) m6A exon//intron       - chr17:80204742-80204743(-) m6A exon//intron       - chr17:80204864-80204865(-) m6A exon//intron       22575960 chr17:80204978-80204979(-) m6A exon//intron       22575960 chr17:80205117-80205118(-) m6A exon//intron       24284625//22575960 chr17:80205352-80205353(-) m6A exon//intron       24284625 chr17:80205383-80205384(-) m6A exon//intron       24284625 chr17:80205389-80205390(-) m6A exon//intron       24284625 chr17:80205437-80205438(-) m6A exon//intron       24284625//22575960 chr17:80205571-80205572(-) m6A exon//intron       24284625//22575960 chr17:80205701-80205702(-) m6A exon//intron       - chr17:80205950-80205951(-) m6A exon//intron       - chr17:80206101-80206102(-) m6A exon//intron       24284625 chr17:80206107-80206108(-) m6A exon//intron       24284625 chr17:80206325-80206326(-) m6A exon//intron       - chr17:80206493-80206494(-) m6A exon//intron       22575960 chr17:80206570-80206571(-) m6A exon//intron       24284625//22575960 chr17:80207213-80207214(-) m6A exon//intron       - chr17:80207235-80207236(-) m6A exon//intron       - chr17:80207404-80207405(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536 chr17:80207415-80207416(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536 chr17:80207434-80207435(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536 chr17:80207537-80207538(-) m6A exon//intron       24284625//27773535 chr17:80207926-80207927(-) m6A 3'UTR//exon//intron       24284625 chr17:80209267-80209268(-) m6A 3'UTR//CDS//exon       27773535 chr17:80210379-80210380(-) m6A 3'UTR//CDS//exon       27773535 chr17:80210941-80210942(-) m6A CDS//exon//intron       24284625//27773535//22575960 chr17:80210947-80210948(-) m6A CDS//exon//intron       24284625//27773535//22575960 chr17:80211061-80211062(-) m6A CDS//exon//intron       24284625//27773535//22575960 chr17:80211088-80211089(-) m6A CDS//exon//intron       24284625//27773535//22575960 chr17:80211161-80211162(-) m6A exon//intron       24284625//27773535//22575960 chr17:80211212-80211213(-) m6A exon//intron       24284625//27773535//22575960 chr17:80211240-80211241(-) m6A exon//intron       24284625//27773535//22575960 chr17:80211280-80211281(-) m6A exon//intron       24284625//24981863//22575960 chr17:80211406-80211407(-) m6A exon//intron       24981863 chr17:80211421-80211422(-) m6A exon//intron       24981863 chr17:80211489-80211490(-) m6A exon//intron       - chr17:80213297-80213298(-) m6A exon//intron       24284625//24981863//27371828 chr17:80213330-80213331(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828 chr17:80213368-80213369(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//26404942//27371828 chr17:80213413-80213414(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//26404942//27371828 chr17:80223247-80223248(-) m6A exon//intron       24284625//24981863//27773535//27371828 chr17:80223270-80223271(-) m6A exon//intron       27773535//27371828 chr17:80223507-80223508(-) m6A exon//intron       26404942 chr17:80223613-80223614(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27371828 chr17:80223618-80223619(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27371828 chr17:80223665-80223666(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536 chr17:80224626-80224627(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536 chr17:80231123-80231124(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//27773536 chr17:80231192-80231193(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27371828//27773536 chr17:80231217-80231218(-) Am CDS//exon       - chr17:80231237-80231238(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22608085 chr17:80231304-80231305(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr17:80231347-80231348(-) m6A 5'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr17:80231446-80231447(-) m6A 5'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr17:80231482-80231483(-) m6A 5'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-18a-3p	Cytoplasm Breast cancer tissue     32370743 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary ovarian tumor cells|Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	CSNK1D	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-18a-3p	Enoxacin 3229 Drug interaction    RC00005791

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-18a-3p	Cisplatin 5702198       25356050 5-Fluorouracil 3385       25356050 Cetuximab -       26107137

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-18a-3p
Interactor2: CSNK1D

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.