Detail Information

Basic Information:


  VIRBase ID:  

HHID00060128

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-532-5p:           TMED7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-532-5p TMED7
miRBase
Accession/Entrez ID		 MIMAT0002888 51014
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-109//p24g3//p24gamma3//p27

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-532-5p
rs1454441567 chrX:50003177    G/A
rs1557180809 chrX:50003176    A/C
rs1557180816 chrX:50003187    G/A
rs375749091 chrX:50003186    C/T
rs782243095 chrX:50003179    G/A
rs782387816 chrX:50003183    G/A
rs1158999000 chrX:50003169    T/C
rs1557180807 chrX:50003171    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMED7
chr5:114950536-114950537(-) m6A 3'UTR       26404942
chr5:114951186-114951187(-) m6A 3'UTR       26404942//27773535
chr5:114951224-114951225(-) m6A 3'UTR       26404942//27773535
chr5:114951273-114951274(-) m6A 3'UTR       27773535
chr5:114951319-114951320(-) m6A 3'UTR       27773535
chr5:114951347-114951348(-) m6A 3'UTR       27773535
chr5:114951474-114951475(-) m6A 3'UTR       27773535
chr5:114951488-114951489(-) m6A 3'UTR       27773535
chr5:114951545-114951546(-) Y 3'UTR       25219674
chr5:114951554-114951555(-) m6A 3'UTR       27773535
chr5:114951588-114951589(-) m6A 3'UTR       24981863//26404942//27773535
chr5:114951622-114951623(-) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085
chr5:114951708-114951709(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951716-114951717(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951746-114951747(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951758-114951759(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951831-114951832(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951931-114951932(-) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085
chr5:114952084-114952085(-) m6A CDS//exon       24284625//24981863//26404942
chr5:114956153-114956154(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr5:114956177-114956178(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956208-114956209(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956256-114956257(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956296-114956297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr5:114961334-114961335(-) m6A CDS//intron       24284625//27773535
chr5:114961399-114961400(-) m6A CDS//intron       27773536
chr5:114961539-114961540(-) m6A 5'UTR//intron       27773536//22575960
chr5:114961609-114961610(-) m6A 5'UTR//exon       24284625//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-532-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Colon tissue|Endothelial cells|Kidney tissue|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TMED7
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-532-5p
Tetrangulol 99188 Drug sensitive
Midostaurin 9829523 Drug resistant
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
Pentamidine isethionate 8813 Drug sensitive
Acridine Yellow G 8672 Drug resistant
Benzethonium chloride 8478 Drug sensitive
o-Aminoazotoluene 7340 Drug resistant
5-Methyl-1,10-phenanthroline 72791 Drug resistant
Berberine iodide 72350 Drug sensitive
Coptisine chloride 72321 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug sensitive
Lauryl isoquinolinium bromide 7132 Drug sensitive
Anaxirone 71218 Drug resistant
Thiocoraline 70698112 Drug resistant
Resorufin 69462 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Laurolinium acetate 67354 Drug sensitive
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive
Tacacoside A2 6712615 Drug sensitive
Baccharinoid B4 6711263 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug resistant
Mevastatin 64715 Drug resistant
Vedelianin 643539 Drug resistant
Methylene blue 6099 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
Bleomycin 5460769 Drug resistant
Berberal 5351462 Drug sensitive
Proscillaridin 5284613 Drug resistant
Ayanin 5280682 Drug resistant
Purapuridine 5250 Drug resistant
Staurosporine, 98% 49831000 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
Latrunculin a 445420 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Antibiotic X-14766A 434840 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Mitoxantrone 4212 Drug resistant
Menadione 4055 Drug sensitive
Homocoralyne sulfopropionate 40154 Drug sensitive
Bortezomib 387447 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
Girolline 362388 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
Acronycine, 2-nitro 342903 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
Dasatinib 3062316 Drug resistant
N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug resistant
Deoxycamptothecin 266552 Drug resistant
Gardenin A 261859 Drug resistant
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug resistant
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Cytembena 23665583 Drug sensitive
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug resistant
Kinetin riboside 20345 Drug resistant
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Ellipticine analog 148569 Drug resistant
Solvent red 1 14678 Drug resistant
[(1R,5R)-16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate 146159135 Drug resistant
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive
1,3-Diamino-5-methylphenazinium chloride 14132 Drug sensitive
Dtxsid30327893 138402823 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 3,4-dihydro-3-beta-D-ribofuranosyl-(9CI) 135492361 Drug resistant
Formycin b 135449281 Drug resistant
Pyrazofurin 135413551 Drug resistant
4-[2-[4-(2-Methylprop-1-enyl)-2-oxoindol-3-yl]hydrazinyl]benzenesulfonamide 135409809 Drug resistant
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant
15-Deacetylsergeolide 125729 Drug sensitive
10-Desacetylbaccatin III 125001 Drug sensitive
Berberine chloride 12456 Drug sensitive
Pepleo 122804 Drug resistant
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
ellipticine, 6-(3-aminopropyl)-9-methoxy-, dihydrochloride - Drug resistant
6-aryl alkyl fluoro quinolone derivative - Drug resistant
7-pentanoyltaxol - Drug resistant
Annamycin Liposomal - Drug resistant
antineoplastic-d655481 - Drug resistant
Aphidicoline glycinate - Drug resistant
arylpurine derivatives - Drug resistant
Carboqone; Carbazilquinone - Drug resistant
euchrysine - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
Indenoisoquinoline derivative - Drug resistant
organosulfur compound - Drug resistant
sphinxolide f - Drug resistant
stereoisomer of nsc 675784-h - Drug resistant
tgf.alpha.-pe40 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
tunicamycin - Drug resistant
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
9-cis-retinol,palmitic acid ester - Drug sensitive
arabinofuranosyl cytosine 5'-oleyl phosphate monosodium, - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug sensitive
naphthalene-1,2-dione, 4-[(4-bromophenyl)amino]-, 1-oxime - Drug sensitive
naphtho[1,2-c]quinolizinium, 13-methyl-, chloride - Drug sensitive
naphtho[2,1-b]quinolizinium, 7-methyl- chloride - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
chalmydocin - Drug sensitive
discorhabdin i - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-532-5p
Curcumin 969516 Drug interaction    RC00005785
Formaldehyde 712 Drug interaction    RC00005773
Gemcitabine 60750 Drug interaction    RC00005782
Vincristine 5978 Drug interaction    RC00005780
Prednisone 5865 Drug interaction    RC00005779
D-Glucose 5793 Drug interaction    RC00005778
Imatinib 5291 Drug interaction    RC00005777
Idarubicin 42890 Drug interaction    RC00005786
5-Fluorouracil 3385 Drug interaction    RC00005776
Doxorubicin 31703 Drug interaction    RC00005781
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005775
Verapamil 2520 Drug interaction    RC00005774
Docetaxel 148124 Drug interaction    RC00005784
Flavylium 145858 Drug interaction    RC00005783
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-532-5p
Cytarabine 6253       23689423
Cisplatin 5702198       25356050
Imatinib 5291       25349971
Idarubicin 42890       23689423

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-532-5p
Interactor2: TMED7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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