Detail Information

Basic Information:


  VIRBase ID:  

HHID00060080

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-513a-5p:           ZMAT3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-513a-5p ZMAT3
miRBase
Accession/Entrez ID		 MIMAT0002877 64393
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAG608//WIG-1//WIG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-513a-5p
rs1461798164 chrX:147213539    T/C
rs1557097540 chrX:147213545    C/T
rs35027589 chrX:147213546    T/TC
rs782289697 chrX:147213540    G/A
rs782304882 chrX:147213541    A/T
rs1557100166 chrX:147225905    A/G
rs369895206 chrX:147225903    A/G
rs782552773 chrX:147225907    C/T
rs782795793 chrX:147225902    G/C
rs782205541 chrX:147213552    T/A
rs782591440 chrX:147213549    C/T
rs1557100170 chrX:147225915    G/T
rs782577003 chrX:147225910    C/T
rs782669807 chrX:147225916    A/AAAGG

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZMAT3
chr3:178748281(-) A-I      intronic
chr3:178748303(-) A-I      intronic
chr3:178748370(-) A-I      intronic
chr3:178749576(-) A-I      intronic
chr3:178749657(-) A-I      intronic
chr3:178782333(-) A-I      intronic
chr3:178782438(-) A-I      intronic
chr3:178782514(-) A-I      intronic
chr3:178746785(-) A-I      intronic
chr3:178746826(-) A-I      intronic
chr3:178746908(-) A-I      intronic
chr3:178782498(-) A-I      intronic
chr3:178782315(-) A-I      intronic
chr3:178749529(-) A-I      intronic
chr3:178749503(-) A-I      intronic
chr3:178782320(-) A-I      intronic
chr3:178748319(-) A-I      intronic
chr3:178749515(-) A-I      intronic
chr3:178749573(-) A-I      intronic
chr3:178748414(-) A-I      intronic
chr3:178749583(-) A-I      intronic
chr3:178744351(-) A-I      intronic
chr3:178762265(-) A-I      intronic
chr3:178783601(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZMAT3
chr3:178740951(-) G-A exon 3'UTR    22484847
chr3:178744455(-) G-C intron -    22484847
chr3:178748414(-) A-G intron -    22484847
chr3:178749503(-) A-G intron -    22484847
chr3:178749515(-) A-G intron -    22484847
chr3:178749529(-) A-G intron -    22484847
chr3:178749573(-) A-G intron -    22484847
chr3:178749583(-) A-G intron -    22484847
chr3:178765486(-) G-T intron -    22484847
chr3:178778367(-) T-C intron -    22484847
chr3:178782498(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZMAT3
chr3:178738549-178738550(-) m6A 3'UTR       -
chr3:178738614-178738615(-) m6A 3'UTR       -
chr3:178742341-178742342(-) m6A 3'UTR       -
chr3:178748766-178748767(-) m6A CDS       24981863//27773535//22608085
chr3:178785301-178785302(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785321-178785322(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785361-178785362(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr3:178785388-178785389(-) m1A CDS       26863196
chr3:178785452-178785453(-) m6A CDS       24284625//24981863//22575960
chr3:178785588-178785589(-) m6A 5'UTR       -
chr3:178789557-178789558(-) m6A 5'UTR       25456834//24981863//27371828
chr3:178789819-178789820(-) m6A 5'UTR       27371828
chr3:178789857-178789858(-) m6A 5'UTR       27371828
chr3:178789948-178789949(-) m6A 5'UTR       24981863//27371828
chr3:178789957-178789958(-) m6A 5'UTR       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-513a-5p
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
ZMAT3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-513a-5p
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug sensitive
Clothixamide maleate 76972759 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Phosphotrienin 6913994 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug resistant
Cisplatin 5702198 Drug sensitive
Tetrocarcin A, sodium salt 54724658 Drug sensitive
Antineoplastic-690266 5469577 Drug sensitive
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive
Heliangolide 5384466 Drug sensitive
N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug resistant
Pyrimethamine 4993 Drug sensitive
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug sensitive
Sjg-136 393111 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant
Dolastatin 11 354399 Drug sensitive
Acronycine, 2-nitro 342903 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive
Dechlorinated rebeccamycin 24203043 Drug sensitive
Azaribine 16574 Drug sensitive
(10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug sensitive
8-Azahypoxanthine 135410720 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
Sendanin 12806435 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug resistant
tgf.alpha.-pe40 - Drug resistant
2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug sensitive
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive
naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive
Camptothecin Derivative - Drug sensitive
crotoxin cd - Drug sensitive
potassium[trichloro(isopropylamine)platinum] - Drug sensitive
rh(iii)-amodiaquine - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-513a-5p
Gemcitabine 60750 Drug interaction    RC00005743
Progesterone 5994 Drug interaction    RC00005739
Eloxatine 5310940 Drug interaction    RC00005744
Paclitaxel 36314 Drug interaction    RC00005742
Doxorubicin 31703 Drug interaction    RC00005741
Ursodeoxycholic acid 31401 Drug interaction    RC00005740
Chemotherapy - Drug interaction    RC00008873
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-513a-5p
Doxorubicin 31703       25698578

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-513a-5p
Interactor2: ZMAT3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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