Basic Information:

  VIRBase ID:  

HHID00059738

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          CEBPZOS:  NR_136316     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	CEBPZOS
miRBase Accession/Entrez ID	MIMAT0002853	100505876
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CEBPZ-AS1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEBPZOS	chr2:37423668-37423669(+) m6A 5'UTR//intron       24981863 chr2:37425669-37425670(+) m6A 5'UTR//intron       24981863 chr2:37425699-37425700(+) m6A 5'UTR//intron       24981863 chr2:37425718-37425719(+) m6A 5'UTR//intron       24981863 chr2:37425738-37425739(+) m6A 5'UTR//intron       24981863 chr2:37425760-37425761(+) m6A 5'UTR//intron       24981863 chr2:37425790-37425791(+) m6A 5'UTR//intron       24981863 chr2:37426864-37426865(+) m6A CDS//exon       24284625//24981863 chr2:37426906-37426907(+) m6A CDS//exon       24981863 chr2:37428843-37428844(+) m6A CDS//exon       27773535 chr2:37428853-37428854(+) m6A CDS       27773535 chr2:37429044-37429045(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr2:37429089-37429090(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr2:37429109-37429110(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr2:37429130-37429131(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr2:37429174-37429175(+) m6A 3'UTR//intron       24981863 chr2:37429260-37429261(+) m6A 3'UTR//intron       24981863//27773535 chr2:37429313-37429314(+) m6A 3'UTR//intron       27773535 chr2:37429971-37429972(+) m6A 3'UTR//intron       27773535 chr2:37430007-37430008(+) m6A 3'UTR//intron       27773535 chr2:37430015-37430016(+) m6A 3'UTR//intron       27773535 chr2:37430040-37430041(+) m6A 3'UTR//intron       27773535 chr2:37430074-37430075(+) m6A 3'UTR//intron       27773535 chr2:37430253-37430254(+) m6A 3'UTR//intron       27773535 chr2:37439083-37439084(+) m6A intron       24981863//27773535//22575960 chr2:37439192-37439193(+) m6A intron       24981863//27773535//22575960 chr2:37439296-37439297(+) m6A intron       27773535 chr2:37439512-37439513(+) m6A intron       24981863//22575960 chr2:37439542-37439543(+) m6A intron       24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	CEBPZOS	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: CEBPZOS

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).