Basic Information:

  VIRBase ID:  

HHID00059734

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          BLOC1S3:  NM_212550     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	BLOC1S3
miRBase Accession/Entrez ID	MIMAT0002853	388552
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BLOS3//HPS8//RP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BLOC1S3	chr19:45684247(+) A-I      3'UTR chr19:45684079(+) A-I      3'UTR chr19:45684089(+) A-I      3'UTR chr19:45684085(+) A-I      3'UTR chr19:45683613(+) A-I      3'UTR chr19:45683751(+) A-I      3'UTR chr19:45683549(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BLOC1S3	chr19:45682740-45682741(+) m6A CDS       25456834//22575960//22608085 chr19:45682769-45682770(+) m6A CDS       25456834//24981863//22575960//22608085 chr19:45682789-45682790(+) m6A CDS       25456834//24981863//22575960//22608085 chr19:45682915-45682916(+) m6A CDS       24209618//24981863//22575960//22608085 chr19:45683050-45683051(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683077-45683078(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683107-45683108(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683127-45683128(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683143-45683144(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683221-45683222(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45683351-45683352(+) m6A 3'UTR//intron       24284625 chr19:45684501-45684502(+) m6A 3'UTR//intron       - chr19:45684587-45684588(+) m6A 3'UTR//exon       24284625//24981863 chr19:45684681-45684682(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr19:45684823-45684824(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45684849-45684850(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:45685033-45685034(+) m6A 3'UTR       24284625//24981863//22608085 chr19:45685043-45685044(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	BLOC1S3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: BLOC1S3

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).