Basic Information:

  VIRBase ID:  

HHID00059732

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          C6orf120:  NM_001317342     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	C6orf120
miRBase Accession/Entrez ID	MIMAT0002853	387263
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C6orf120	chr6:170102415-170102416(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr6:170102431-170102432(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr6:170102455-170102456(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr6:170102476-170102477(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr6:170102712-170102713(+) m6A CDS       24284625//22608085 chr6:170102733-170102734(+) m6A CDS       24284625//22608085 chr6:170102914-170102915(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:170103106-170103107(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:170103158-170103159(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr6:170103195-170103196(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr6:170103345-170103346(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr6:170103365-170103366(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr6:170103571-170103572(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr6:170103790-170103791(+) m6A 3'UTR       24981863//22608085 chr6:170104346-170104347(+) m6A 3'UTR       24981863//22608085 chr6:170104430-170104431(+) m6A 3'UTR       24981863//26404942//22608085 chr6:170104465-170104466(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr6:170104491-170104492(+) m6A 3'UTR       24284625//24981863//22608085 chr6:170104519-170104520(+) m6A 3'UTR       24284625//24981863//22608085 chr6:170104604-170104605(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	C6orf120	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: C6orf120

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).