Basic Information:

  VIRBase ID:  

HHID00059727

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          PGM2L1:  NM_173582     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	PGM2L1
miRBase Accession/Entrez ID	MIMAT0002853	283209
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BM32A//PMMLP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PGM2L1	chr11:74090963(-) A-I      intronic chr11:74093723(-) A-I      intronic chr11:74093720(-) A-I      intronic chr11:74093763(-) A-I      intronic chr11:74093740(-) A-I      intronic chr11:74100959(-) A-I      intronic chr11:74100297(-) A-I      intronic chr11:74093586(-) A-I      intronic chr11:74080814(-) A-I      intronic chr11:74071228(-) A-I      intronic chr11:74100215(-) A-I      intronic chr11:74100298(-) A-I      intronic chr11:74100606(-) A-I      intronic chr11:74100617(-) A-I      intronic chr11:74088373(-) A-I      intronic chr11:74106724(-) A-I      intronic chr11:74100631(-) A-I      intronic chr11:74090724(-) A-I      intronic chr11:74092780(-) A-I      intronic chr11:74042563(-) A-I      3'UTR chr11:74046172(-) A-I      3'UTR chr11:74046259(-) A-I      3'UTR chr11:74093817(-) A-I      intronic chr11:74106555(-) A-I      intronic chr11:74100188(-) A-I      intronic chr11:74067906(-) A-I      intronic chr11:74093775(-) A-I      intronic chr11:74107598(-) A-I      intronic chr11:74100784(-) A-I      intronic chr11:74107182(-) A-I      intronic chr11:74092769(-) A-I      intronic chr11:74100630(-) A-I      intronic chr11:74107731(-) A-I      intronic chr11:74054962(-) A-I      intronic chr11:74092721(-) A-I      intronic chr11:74093752(-) A-I      intronic chr11:74042580(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PGM2L1	chr11:74102838(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PGM2L1	chr11:74044511-74044512(-) m6A 3'UTR       24981863 chr11:74044568-74044569(-) m6A 3'UTR       24981863 chr11:74044793-74044794(-) m6A 3'UTR       24981863//27773535 chr11:74044806-74044807(-) m6A 3'UTR       24981863//27773535 chr11:74044823-74044824(-) m6A 3'UTR       24981863//27773535 chr11:74044896-74044897(-) m6A 3'UTR       24981863//27773535 chr11:74044943-74044944(-) m6A 3'UTR       27773535 chr11:74047537-74047538(-) m6A 3'UTR       24284625 chr11:74047542-74047543(-) m6A 3'UTR       24284625//24981863//27773535 chr11:74047626-74047627(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr11:74047640-74047641(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr11:74047655-74047656(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr11:74047717-74047718(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr11:74047765-74047766(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr11:74047774-74047775(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr11:74054028-74054029(-) Am CDS       - chr11:74109195-74109196(-) m6A CDS//exon       27371828 chr11:74109275-74109276(-) m6A 5'UTR//exon       27371828//27773536 chr11:74109289-74109290(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr11:74109339-74109340(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr11:74109386-74109387(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr11:74109417-74109418(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr11:74109423-74109424(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr11:74109470-74109471(-) m6A 5'UTR       24981863//27371828 chr11:74109479-74109480(-) m6A 5'UTR       24981863//27371828 chr11:74109485-74109486(-) m6A 5'UTR       24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	PGM2L1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: PGM2L1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).