Basic Information:

  VIRBase ID:  

HHID00059724

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          ZBTB9:  NM_152735     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	ZBTB9
miRBase Accession/Entrez ID	MIMAT0002853	221504
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF919

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB9	chr6:33422441-33422442(+) m6A 5'UTR//intron       24981863 chr6:33422455-33422456(+) m6A 5'UTR//intron       - chr6:33422494-33422495(+) m6A 5'UTR//intron       25456834 chr6:33422883-33422884(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:33422940-33422941(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:33422992-33422993(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:33423050-33423051(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:33423303-33423304(+) m6A CDS//intron       24981863 chr6:33423337-33423338(+) m6A CDS//intron       24981863 chr6:33423408-33423409(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:33423482-33423483(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr6:33423550-33423551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423576-33423577(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423623-33423624(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423740-33423741(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423777-33423778(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423804-33423805(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423826-33423827(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33423908-33423909(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085 chr6:33423953-33423954(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085 chr6:33424002-33424003(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33424170-33424171(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33424249-33424250(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33424287-33424288(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33424327-33424328(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr6:33424426-33424427(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr6:33424472-33424473(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:33424572-33424573(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:33424604-33424605(+) m6A 3'UTR       24981863//22608085 chr6:33424648-33424649(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	ZBTB9	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: ZBTB9

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).