Basic Information:

  VIRBase ID:  

HHID00059720

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          C2orf69:  NM_153689     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	C2orf69
miRBase Accession/Entrez ID	MIMAT0002853	205327
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C2orf69	chr2:200785558(+) A-I      intronic chr2:200785859(+) A-I      intronic chr2:200817807(+) A-I      intronic chr2:200785532(+) A-I      intronic chr2:200791372(+) A-I      3'UTR chr2:200791267(+) A-I      3'UTR chr2:200788952(+) A-I      intronic chr2:200788944(+) A-I      intronic chr2:200777635(+) A-I      intronic chr2:200786948(+) A-I      intronic chr2:200789063(+) A-I      intronic chr2:200789050(+) A-I      intronic chr2:200791258(+) A-I      3'UTR chr2:200789019(+) A-I      intronic chr2:200785869(+) A-I      intronic chr2:200777640(+) A-I      intronic chr2:200788999(+) A-I      intronic chr2:200785416(+) A-I      intronic chr2:200785991(+) A-I      intronic chr2:200785402(+) A-I      intronic chr2:200786855(+) A-I      intronic chr2:200789081(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C2orf69	chr2:200785402(+) A-G intron -    22484847 chr2:200785416(+) A-G intron -    22484847 chr2:200785869(+) A-G intron -    22484847 chr2:200791266(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C2orf69	chr2:200776139-200776140(+) m6A 5'UTR//exon       - chr2:200776254-200776255(+) m6A CDS//exon       - chr2:200776261-200776262(+) m6A CDS//exon       - chr2:200789833-200789834(+) m6A CDS//intron       24284625//22608085 chr2:200789978-200789979(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr2:200790088-200790089(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790159-200790160(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790298-200790299(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790304-200790305(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790333-200790334(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:200790417-200790418(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790629-200790630(+) m6A 3'UTR//intron       24981863//22608085 chr2:200790646-200790647(+) m6A 3'UTR//intron       22608085 chr2:200820138-200820139(+) m6A exon       24981863 chr2:200820228-200820229(+) m6A exon       24981863//27371828 chr2:200820269-200820270(+) m6A exon       25456834//24981863//27371828 chr2:200820306-200820307(+) m6A exon       25456834//24981863//27371828//27773536 chr2:200820596-200820597(+) m6A exon       24284625//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	C2orf69	Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: C2orf69

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).