Basic Information:

  VIRBase ID:  

HHID00059711

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          TMEM167A:  NM_174909     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	TMEM167A
miRBase Accession/Entrez ID	MIMAT0002853	153339
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM167

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM167A	chr5:82370728(-) A-I      intronic chr5:82370767(-) A-I      intronic chr5:82357352(-) A-I      intronic chr5:82357366(-) A-I      intronic chr5:82368486(-) A-I      intronic chr5:82371512(-) A-I      intronic chr5:82368423(-) A-I      intronic chr5:82368539(-) A-I      intronic chr5:82370727(-) A-I      intronic chr5:82371371(-) A-I      intronic chr5:82371481(-) A-I      intronic chr5:82371398(-) A-I      intronic chr5:82371391(-) A-I      intronic chr5:82357418(-) A-I      intronic chr5:82370796(-) A-I      intronic chr5:82368530(-) A-I      intronic chr5:82357487(-) A-I      intronic chr5:82357415(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM167A	chr5:82357418(-) A-G intron -    22484847 chr5:82370861(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM167A	chr5:82349080-82349081(-) m6A 3'UTR       24284625//25456834//22608085 chr5:82349209-82349210(-) m6A 3'UTR       22608085 chr5:82352749-82352750(-) m6A 3'UTR//exon       24981863//22608085 chr5:82352801-82352802(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82352850-82352851(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82352856-82352857(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82360830-82360831(-) m6A CDS//exon//intron       24284625 chr5:82360841-82360842(-) m6A CDS//exon//intron       24284625 chr5:82367200-82367201(-) m6A exon//intron       24284625//24981863 chr5:82373205-82373206(-) m6A 5'UTR//exon//intron       25456834//24981863 chr5:82373649-82373650(-) m6A exon       25456834 chr5:82373665-82373666(-) m6A exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	TMEM167A	Chromatin K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: TMEM167A

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).