Basic Information:

  VIRBase ID:  

HHID00059710

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          FAM117B:  NM_173511     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	FAM117B
miRBase Accession/Entrez ID	MIMAT0002853	150864
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALS2CR13

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM117B	chr2:203596309(+) A-I      intronic chr2:203596306(+) A-I      intronic chr2:203596303(+) A-I      intronic chr2:203596299(+) A-I      intronic chr2:203596295(+) A-I      intronic chr2:203597332(+) A-I      intronic chr2:203596293(+) A-I      intronic chr2:203596283(+) A-I      intronic chr2:203588958(+) A-I      intronic chr2:203588957(+) A-I      intronic chr2:203588955(+) A-I      intronic chr2:203602559(+) A-I      intronic chr2:203606101(+) A-I      intronic chr2:203606091(+) A-I      intronic chr2:203606083(+) A-I      intronic chr2:203605989(+) A-I      intronic chr2:203605972(+) A-I      intronic chr2:203605967(+) A-I      intronic chr2:203605957(+) A-I      intronic chr2:203605956(+) A-I      intronic chr2:203605947(+) A-I      intronic chr2:203605936(+) A-I      intronic chr2:203605933(+) A-I      intronic chr2:203604846(+) A-I      intronic chr2:203604845(+) A-I      intronic chr2:203588948(+) A-I      intronic chr2:203588928(+) A-I      intronic chr2:203588923(+) A-I      intronic chr2:203564007(+) A-I      intronic chr2:203563994(+) A-I      intronic chr2:203601335(+) A-I      intronic chr2:203601334(+) A-I      intronic chr2:203601331(+) A-I      intronic chr2:203601264(+) A-I      intronic chr2:203601220(+) A-I      intronic chr2:203597360(+) A-I      intronic chr2:203597343(+) A-I      intronic chr2:203597336(+) A-I      intronic chr2:203597327(+) A-I      intronic chr2:203564047(+) A-I      intronic chr2:203567035(+) A-I      intronic chr2:203567483(+) A-I      intronic chr2:203602466(+) A-I      intronic chr2:203602486(+) A-I      intronic chr2:203602499(+) A-I      intronic chr2:203602522(+) A-I      intronic chr2:203603733(+) A-I      intronic chr2:203515946(+) A-I      intronic chr2:203515951(+) A-I      intronic chr2:203517024(+) A-I      intronic chr2:203569834(+) A-I      intronic chr2:203569840(+) A-I      intronic chr2:203517033(+) A-I      intronic chr2:203517763(+) A-I      intronic chr2:203603769(+) A-I      intronic chr2:203603809(+) A-I      intronic chr2:203603833(+) A-I      intronic chr2:203604279(+) A-I      intronic chr2:203604305(+) A-I      intronic chr2:203604418(+) A-I      intronic chr2:203517799(+) A-I      intronic chr2:203604753(+) A-I      intronic chr2:203604781(+) A-I      intronic chr2:203604785(+) A-I      intronic chr2:203604821(+) A-I      intronic chr2:203605003(+) A-I      intronic chr2:203604985(+) A-I      intronic chr2:203604989(+) A-I      intronic chr2:203604992(+) A-I      intronic chr2:203517804(+) A-I      intronic chr2:203517979(+) A-I      intronic chr2:203526397(+) A-I      intronic chr2:203605040(+) A-I      intronic chr2:203605906(+) A-I      intronic chr2:203606490(+) A-I      intronic chr2:203619506(+) A-I      intronic chr2:203526430(+) A-I      intronic chr2:203526553(+) A-I      intronic chr2:203527469(+) A-I      intronic chr2:203569869(+) A-I      intronic chr2:203590145(+) A-I      intronic chr2:203593827(+) A-I      intronic chr2:203593828(+) A-I      intronic chr2:203593860(+) A-I      intronic chr2:203596811(+) A-I      intronic chr2:203597342(+) A-I      intronic chr2:203597453(+) A-I      intronic chr2:203597456(+) A-I      intronic chr2:203601333(+) A-I      intronic chr2:203602464(+) A-I      intronic chr2:203530417(+) A-I      intronic chr2:203548690(+) A-I      intronic chr2:203548702(+) A-I      intronic chr2:203552207(+) A-I      intronic chr2:203561615(+) A-I      intronic chr2:203561754(+) A-I      intronic chr2:203562671(+) A-I      intronic chr2:203563407(+) A-I      intronic chr2:203563972(+) A-I      intronic chr2:203563408(+) A-I      intronic chr2:203563954(+) A-I      intronic chr2:203563964(+) A-I      intronic chr2:203531867(+) A-I      intronic chr2:203531904(+) A-I      intronic chr2:203536958(+) A-I      intronic chr2:203540483(+) A-I      intronic chr2:203540665(+) A-I      intronic chr2:203563999(+) A-I      intronic chr2:203564000(+) A-I      intronic chr2:203564003(+) A-I      intronic chr2:203563992(+) A-I      intronic chr2:203564023(+) A-I      intronic chr2:203501724(+) A-I      intronic chr2:203505450(+) A-I      intronic chr2:203512986(+) A-I      intronic chr2:203564029(+) A-I      intronic chr2:203604640(+) A-I      intronic chr2:203619502(+) A-I      intronic chr2:203606444(+) A-I      intronic chr2:203605981(+) A-I      intronic chr2:203595270(+) A-I      intronic chr2:203604444(+) A-I      intronic chr2:203606412(+) A-I      intronic chr2:203540543(+) A-I      intronic chr2:203563420(+) A-I      intronic chr2:203606498(+) A-I      intronic chr2:203590146(+) A-I      intronic chr2:203601306(+) A-I      intronic chr2:203604817(+) A-I      intronic chr2:203592974(+) A-I      intronic chr2:203561596(+) A-I      intronic chr2:203592780(+) A-I      intronic chr2:203606000(+) A-I      intronic chr2:203605990(+) A-I      intronic chr2:203619394(+) A-I      intronic chr2:203562809(+) A-I      intronic chr2:203605043(+) A-I      intronic chr2:203602425(+) A-I      intronic chr2:203566994(+) A-I      intronic chr2:203597496(+) A-I      intronic chr2:203562697(+) A-I      intronic chr2:203606502(+) A-I      intronic chr2:203590171(+) A-I      intronic chr2:203604234(+) A-I      intronic chr2:203568214(+) A-I      intronic chr2:203562849(+) A-I      intronic chr2:203578510(+) A-I      intronic chr2:203563988(+) A-I      intronic chr2:203533031(+) A-I      intronic chr2:203606036(+) A-I      intronic chr2:203604802(+) A-I      intronic chr2:203533114(+) A-I      intronic chr2:203626393(+) A-I      intronic chr2:203566928(+) A-I      intronic chr2:203514733(+) A-I      intronic chr2:203563974(+) A-I      intronic chr2:203563998(+) A-I      intronic chr2:203516726(+) A-I      intronic chr2:203592815(+) A-I      intronic chr2:203605982(+) A-I      intronic chr2:203604775(+) A-I      intronic chr2:203523165(+) A-I      intronic chr2:203595273(+) A-I      intronic chr2:203563997(+) A-I      intronic chr2:203552331(+) A-I      intronic chr2:203597295(+) A-I      intronic chr2:203602429(+) A-I      intronic chr2:203537520(+) A-I      intronic chr2:203592802(+) A-I      intronic chr2:203598989(+) A-I      intronic chr2:203567303(+) A-I      intronic chr2:203605941(+) A-I      intronic chr2:203533180(+) A-I      intronic chr2:203595138(+) A-I      intronic chr2:203601342(+) A-I      intronic chr2:203552316(+) A-I      intronic chr2:203513097(+) A-I      intronic chr2:203604631(+) A-I      intronic chr2:203596339(+) A-I      intronic chr2:203596638(+) A-I      intronic chr2:203514718(+) A-I      intronic chr2:203516708(+) A-I      intronic chr2:203562609(+) A-I      intronic chr2:203569526(+) A-I      intronic chr2:203604808(+) A-I      intronic chr2:203597308(+) A-I      intronic chr2:203601400(+) A-I      intronic chr2:203603656(+) A-I      intronic chr2:203572271(+) A-I      intronic chr2:203537715(+) A-I      intronic chr2:203604956(+) A-I      intronic chr2:203533201(+) A-I      intronic chr2:203539837(+) A-I      intronic chr2:203561665(+) A-I      intronic chr2:203548693(+) A-I      intronic chr2:203548007(+) A-I      intronic chr2:203596658(+) A-I      intronic chr2:203601221(+) A-I      intronic chr2:203593805(+) A-I      intronic chr2:203563989(+) A-I      intronic chr2:203505436(+) A-I      intronic chr2:203593914(+) A-I      intronic chr2:203603916(+) A-I      intronic chr2:203568153(+) A-I      intronic chr2:203619534(+) A-I      intronic chr2:203596641(+) A-I      intronic chr2:203505397(+) A-I      intronic chr2:203606096(+) A-I      intronic chr2:203606441(+) A-I      intronic chr2:203596421(+) A-I      intronic chr2:203604457(+) A-I      intronic chr2:203513602(+) A-I      intronic chr2:203603791(+) A-I      intronic chr2:203601308(+) A-I      intronic chr2:203572571(+) A-I      intronic chr2:203604315(+) A-I      intronic chr2:203604307(+) A-I      intronic chr2:203603778(+) A-I      intronic chr2:203556126(+) A-I      intronic chr2:203605986(+) A-I      intronic chr2:203606340(+) A-I      intronic chr2:203603882(+) A-I      intronic chr2:203552159(+) A-I      intronic chr2:203592837(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM117B	chr2:203601221(+) A-I intron -    21960545 chr2:203566854(+) A-G intron -    22484847 chr2:203566994(+) A-G intron -    22484847 chr2:203592725(+) A-G intron -    22484847 chr2:203596658(+) A-G intron -    22484847 chr2:203601400(+) A-G intron -    22484847 chr2:203601405(+) A-G intron -    22484847 chr2:203603791(+) A-G intron -    22484847 chr2:203606466(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM117B	chr2:203630215-203630216(+) m6A CDS       24284625//24981863 chr2:203630389-203630390(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:203630401-203630402(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:203630418-203630419(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:203630462-203630463(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:203630526-203630527(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:203630711-203630712(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203630744-203630745(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203630773-203630774(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203630784-203630785(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203630884-203630885(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr2:203630950-203630951(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203631037-203631038(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:203631099-203631100(+) m6A 3'UTR       24981863//22608085 chr2:203631126-203631127(+) m6A 3'UTR       24981863//22608085 chr2:203632940-203632941(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	FAM117B	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: FAM117B

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).