Detail Information

Basic Information:


  VIRBase ID:  

HHID00059709

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           DUSP18:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p DUSP18
miRBase
Accession/Entrez ID		 MIMAT0002853 150290
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DSP18//DUSP20//LMWDSP20

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DUSP18
chr22:31057533(-) A-I      3'UTR
chr22:31057508(-) A-I      3'UTR
chr22:31058794(-) A-I      3'UTR
chr22:31058766(-) A-I      3'UTR
chr22:31058750(-) A-I      3'UTR
chr22:31058610(-) A-I      3'UTR
chr22:31058609(-) A-I      3'UTR
chr22:31058597(-) A-I      3'UTR
chr22:31058579(-) A-I      3'UTR
chr22:31057564(-) A-I      3'UTR
chr22:31050140(-) A-I      3'UTR
chr22:31058754(-) A-I      3'UTR
chr22:31057434(-) A-I      3'UTR
chr22:31050252(-) A-I      3'UTR
chr22:31058748(-) A-I      3'UTR
chr22:31057488(-) A-I      3'UTR
chr22:31057528(-) A-I      3'UTR
chr22:31058747(-) A-I      3'UTR
chr22:31050176(-) A-I      3'UTR
chr22:31058734(-) A-I      3'UTR
chr22:31057437(-) A-I      3'UTR
chr22:31058697(-) A-I      3'UTR
chr22:31057532(-) A-I      3'UTR
chr22:31057574(-) A-I      3'UTR
chr22:31050166(-) A-I      3'UTR
chr22:31058650(-) A-I      3'UTR
chr22:31050134(-) A-I      3'UTR
chr22:31058646(-) A-I      3'UTR
chr22:31057541(-) A-I      3'UTR
chr22:31057457(-) A-I      3'UTR
chr22:31058631(-) A-I      3'UTR
chr22:31058596(-) A-I      3'UTR
chr22:31058620(-) A-I      3'UTR
chr22:31057547(-) A-I      3'UTR
chr22:31058593(-) A-I      3'UTR
chr22:31057551(-) A-I      3'UTR
chr22:31050238(-) A-I      3'UTR
chr22:31050243(-) A-I      3'UTR
chr22:31057557(-) A-I      3'UTR
chr22:31057568(-) A-I      3'UTR
chr22:31050244(-) A-I      3'UTR
chr22:31057474(-) A-I      3'UTR
chr22:31058592(-) A-I      3'UTR
chr22:31055631(-) A-I      intronic
chr22:31054088(-) A-I      intronic
chr22:31054942(-) A-I      intronic
chr22:31051397(-) A-I      intronic
chr22:31056359(-) A-I      intronic
chr22:31052187(-) A-I      intronic
chr22:31056985(-) A-I      intronic
chr22:31054062(-) A-I      intronic
chr22:31057060(-) A-I      intronic
chr22:31056325(-) A-I      intronic
chr22:31051335(-) A-I      intronic
chr22:31058740(-) A-I      3'UTR
chr22:31058721(-) A-I      3'UTR
chr22:31058692(-) A-I      3'UTR
chr22:31058759(-) A-I      3'UTR
chr22:31058785(-) A-I      3'UTR
chr22:31058733(-) A-I      3'UTR
chr22:31058811(-) A-I      3'UTR
chr22:31058775(-) A-I      3'UTR
chr22:31058783(-) A-I      3'UTR
chr22:31051271(-) A-I      intronic
chr22:31055035(-) A-I      intronic
chr22:31057101(-) A-I      intronic
chr22:31056387(-) A-I      intronic
chr22:31052210(-) A-I      intronic
chr22:31051221(-) A-I      intronic
chr22:31051277(-) A-I      intronic
chr22:31056910(-) A-I      intronic
chr22:31053727(-) A-I      intronic
chr22:31056968(-) A-I      intronic
chr22:31054089(-) A-I      intronic
chr22:31057100(-) A-I      intronic
chr22:31056433(-) A-I      intronic
chr22:31056978(-) A-I      intronic
chr22:31053324(-) A-I      intronic
chr22:31054087(-) A-I      intronic
chr22:31056408(-) A-I      intronic
chr22:31056932(-) A-I      intronic
chr22:31056923(-) A-I      intronic
chr22:31056324(-) A-I      intronic
chr22:31051322(-) A-I      intronic
chr22:31053702(-) A-I      intronic
chr22:31057054(-) A-I      intronic
chr22:31051332(-) A-I      intronic
chr22:31052099(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DUSP18
chr22:31058622(-) A-I exon 3'UTR    15342557
chr22:31058648(-) A-I exon 3'UTR    15342557
chr22:31058692(-) A-I exon 3'UTR    15342557
chr22:31058721(-) A-I exon 3'UTR    15342557
chr22:31058733(-) A-I exon 3'UTR    15342557
chr22:31058740(-) A-I exon 3'UTR    15342557
chr22:31058775(-) A-I exon 3'UTR    15342557
chr22:31058785(-) A-I exon 3'UTR    15342557
chr22:31058811(-) A-I exon 3'UTR    15342557
chr22:31058611(-) A-I exon 3'UTR    22327324
chr22:31058634(-) A-I exon 3'UTR    22327324
chr22:31058694(-) A-I exon 3'UTR    22327324
chr22:31058634(-) A-G exon 3'UTR    21725310
chr22:31058785(-) A-G exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DUSP18
chr22:31049910-31049911(-) m6A intron       24981863
chr22:31049938-31049939(-) m6A intron       24981863
chr22:31050283-31050284(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31050348-31050349(-) m6A 3'UTR//intron       24209618//27773535//27371828//22608085
chr22:31057531-31057532(-) m6A 3'UTR//intron       24981863
chr22:31057634-31057635(-) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr22:31057665-31057666(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057677-31057678(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057709-31057710(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057721-31057722(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057776-31057777(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057788-31057789(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057839-31057840(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057875-31057876(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057914-31057915(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31057975-31057976(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31057998-31057999(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31058154-31058155(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr22:31058299-31058300(-) m6A 3'UTR//intron       24209618//24981863
chr22:31058340-31058341(-) m6A 3'UTR//intron       25456834//24981863//22608085
chr22:31058406-31058407(-) m6A 3'UTR//intron       24284625//25456834//24981863//22608085
chr22:31058456-31058457(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr22:31059097-31059098(-) m6A 3'UTR//intron       24209618//25456834//24981863//22608085
chr22:31059241-31059242(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr22:31059318-31059319(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059347-31059348(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059353-31059354(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059505-31059506(-) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr22:31059590-31059591(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr22:31059817-31059818(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr22:31060056-31060057(-) m6A 5'UTR//intron       22608085
chr22:31060984-31060985(-) m6A 5'UTR//intron       -
chr22:31063442-31063443(-) m6A 5'UTR//intron       -
chr22:31063474-31063475(-) m6A 5'UTR//exon       -
chr22:31063722-31063723(-) m6A 5'UTR//exon       27371828
chr22:31063832-31063833(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
DUSP18
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: DUSP18

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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