Detail Information

Basic Information:


  VIRBase ID:  

HHID00059705

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           ZNF280B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p ZNF280B
miRBase
Accession/Entrez ID		 MIMAT0002853 140883
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 5'OY11.1//D87009.C22.3//SUHW2//ZNF279//ZNF632

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF280B
chr22:22854998(-) A-I      intronic
chr22:22858635(-) A-I      intronic
chr22:22847033(-) A-I      intronic
chr22:22849103(-) A-I      intronic
chr22:22849163(-) A-I      intronic
chr22:22851317(-) A-I      intronic
chr22:22851721(-) A-I      intronic
chr22:22845916(-) A-I      intronic
chr22:22850553(-) A-I      intronic
chr22:22851170(-) A-I      intronic
chr22:22850555(-) A-I      intronic
chr22:22850620(-) A-I      intronic
chr22:22851227(-) A-I      intronic
chr22:22851302(-) A-I      intronic
chr22:22855687(-) A-I      intronic
chr22:22855696(-) A-I      intronic
chr22:22855707(-) A-I      intronic
chr22:22855731(-) A-I      intronic
chr22:22855947(-) A-I      intronic
chr22:22855974(-) A-I      intronic
chr22:22858513(-) A-I      intronic
chr22:22858580(-) A-I      intronic
chr22:22850559(-) A-I      intronic
chr22:22858659(-) A-I      intronic
chr22:22858678(-) A-I      intronic
chr22:22858689(-) A-I      intronic
chr22:22847510(-) A-I      intronic
chr22:22847506(-) A-I      intronic
chr22:22847505(-) A-I      intronic
chr22:22846007(-) A-I      intronic
chr22:22845973(-) A-I      intronic
chr22:22845962(-) A-I      intronic
chr22:22845959(-) A-I      intronic
chr22:22854971(-) A-I      intronic
chr22:22855252(-) A-I      intronic
chr22:22851286(-) A-I      intronic
chr22:22856131(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF280B
chr22:22840126-22840127(-) m6A 3'UTR       27773535
chr22:22840751-22840752(-) m6A 3'UTR//intron       24981863
chr22:22840779-22840780(-) m6A 3'UTR//intron       24981863
chr22:22840789-22840790(-) m6A 3'UTR//intron       24981863
chr22:22840862-22840863(-) m6A 3'UTR//intron       24981863
chr22:22841904-22841905(-) m6A 3'UTR       27773535
chr22:22841957-22841958(-) m6A 3'UTR       27773535//22608085
chr22:22841984-22841985(-) m6A 3'UTR       27773535//22608085
chr22:22842019-22842020(-) m6A 3'UTR       24981863//27773535//22608085
chr22:22842032-22842033(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr22:22842042-22842043(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr22:22842055-22842056(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr22:22842139-22842140(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842199-22842200(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842228-22842229(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr22:22842285-22842286(-) m6A CDS       24284625//24981863//27773535//22608085
chr22:22842396-22842397(-) m6A CDS       27773535//22608085
chr22:22842440-22842441(-) m6A CDS       27773535//22608085
chr22:22842465-22842466(-) m6A CDS       27773535//22608085
chr22:22842542-22842543(-) m6A CDS       24981863//27773535//22608085
chr22:22842573-22842574(-) m6A CDS       24981863//27773535//22608085
chr22:22842701-22842702(-) m6A CDS       24284625//24981863//27773535//22608085
chr22:22842816-22842817(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842823-22842824(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842850-22842851(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842906-22842907(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842911-22842912(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842939-22842940(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:22842998-22842999(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr22:22843156-22843157(-) m6A CDS       24981863//27773535//22608085
chr22:22843181-22843182(-) m6A CDS       24284625//24981863//27773535//22608085
chr22:22843354-22843355(-) m6A CDS       24284625//24981863//27773535//22608085
chr22:22843446-22843447(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr22:22843538-22843539(-) m6A CDS       24209618//24981863//27773535//27371828//22608085
chr22:22843547-22843548(-) m6A CDS       24209618//24981863//27773535//22608085
chr22:22843561-22843562(-) m6A CDS       24209618//24981863//27773535//22608085
chr22:22843615-22843616(-) m6A CDS       24209618//24981863//27773535//22608085
chr22:22843660-22843661(-) m6A CDS       24981863//27773535//22608085
chr22:22843665-22843666(-) m6A CDS       24981863//27773535//22608085
chr22:22843676-22843677(-) m6A CDS       24981863//27773535//22608085
chr22:22843687-22843688(-) m6A CDS       24981863//27773535//22608085
chr22:22843717-22843718(-) m6A CDS       24981863//27773535//22608085
chr22:22843761-22843762(-) m6A 5'UTR       24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
ZNF280B
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: ZNF280B

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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