Basic Information:

  VIRBase ID:  

HHID00059703

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          NUP35:  NM_138285     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	NUP35
miRBase Accession/Entrez ID	MIMAT0002853	129401
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MP-44//MP44//NP44//NUP53

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUP35	chr2:184001739(+) A-I      intronic chr2:184025369(+) A-I      intronic chr2:184025345(+) A-I      intronic chr2:184025327(+) A-I      intronic chr2:184025316(+) A-I      intronic chr2:184005564(+) A-I      intronic chr2:184005561(+) A-I      intronic chr2:183997066(+) A-I      intronic chr2:183997123(+) A-I      intronic chr2:184001653(+) A-I      intronic chr2:184003959(+) A-I      intronic chr2:184003974(+) A-I      intronic chr2:184004004(+) A-I      intronic chr2:184004038(+) A-I      intronic chr2:184010805(+) A-I      intronic chr2:184025555(+) A-I      intronic chr2:184014845(+) A-I      intronic chr2:184025599(+) A-I      intronic chr2:184014704(+) A-I      intronic chr2:184013597(+) A-I      intronic chr2:184013578(+) A-I      intronic chr2:184013577(+) A-I      intronic chr2:184013513(+) A-I      intronic chr2:184011389(+) A-I      intronic chr2:184011386(+) A-I      intronic chr2:184011375(+) A-I      intronic chr2:184010858(+) A-I      intronic chr2:184007470(+) A-I      intronic chr2:183996890(+) A-I      intronic chr2:184010844(+) A-I      intronic chr2:184010788(+) A-I      intronic chr2:184005559(+) A-I      intronic chr2:184007763(+) A-I      intronic chr2:184007753(+) A-I      intronic chr2:184007724(+) A-I      intronic chr2:184007707(+) A-I      intronic chr2:184007482(+) A-I      intronic chr2:183992081(+) A-I      intronic chr2:184007417(+) A-I      intronic chr2:184007326(+) A-I      intronic chr2:183992546(+) A-I      intronic chr2:183996831(+) A-I      intronic chr2:183996852(+) A-I      intronic chr2:184025594(+) A-I      intronic chr2:184025591(+) A-I      intronic chr2:184011559(+) A-I      intronic chr2:183999483(+) A-I      intronic chr2:184007460(+) A-I      intronic chr2:184021207(+) A-I      intronic chr2:183997225(+) A-I      intronic chr2:184007692(+) A-I      intronic chr2:184025556(+) A-I      intronic chr2:183997215(+) A-I      intronic chr2:184021148(+) A-I      intronic chr2:184021197(+) A-I      intronic chr2:184001679(+) A-I      intronic chr2:184007274(+) A-I      intronic chr2:184025292(+) A-I      intronic chr2:184003998(+) A-I      intronic chr2:184014735(+) A-I      intronic chr2:184000517(+) A-I      intronic chr2:183992539(+) A-I      intronic chr2:184025307(+) A-I      intronic chr2:184020412(+) A-I      intronic chr2:183996880(+) A-I      intronic chr2:183990876(+) A-I      intronic chr2:184000512(+) A-I      intronic chr2:184007273(+) A-I      intronic chr2:184000578(+) A-I      intronic chr2:184000471(+) A-I      intronic chr2:184014784(+) A-I      intronic chr2:183997182(+) A-I      intronic chr2:184025354(+) A-I      intronic chr2:183997067(+) A-I      intronic chr2:184010861(+) A-I      intronic chr2:184001675(+) A-I      intronic chr2:183997206(+) A-I      intronic chr2:184004076(+) A-I      intronic chr2:184005431(+) A-I      intronic chr2:183992695(+) A-I      intronic chr2:184011490(+) A-I      intronic chr2:184025295(+) A-I      intronic chr2:183996694(+) A-I      intronic chr2:184005501(+) A-I      intronic chr2:184002192(+) A-I      intronic chr2:184011534(+) A-I      intronic chr2:184005409(+) A-I      intronic chr2:183996851(+) A-I      intronic chr2:184007397(+) A-I      intronic chr2:184010700(+) A-I      intronic chr2:184001576(+) A-I      intronic chr2:184002454(+) A-I      intronic chr2:184005471(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUP35	chr2:183992539(+) A-G intron -    22484847 chr2:183996694(+) A-G intron -    22484847 chr2:183996763(+) A-G intron -    22484847 chr2:183996773(+) A-G intron -    22484847 chr2:183996775(+) A-G intron -    22484847 chr2:183996788(+) A-G intron -    22484847 chr2:183996880(+) A-G intron -    22484847 chr2:183997067(+) A-G intron -    22484847 chr2:183997206(+) A-G intron -    22484847 chr2:183997267(+) A-G intron -    22484847 chr2:184001671(+) A-G intron -    22484847 chr2:184001675(+) A-G intron -    22484847 chr2:184001679(+) A-G intron -    22484847 chr2:184002422(+) A-G intron -    22484847 chr2:184002455(+) A-G intron -    22484847 chr2:184003998(+) A-G intron -    22484847 chr2:184004020(+) A-G intron -    22484847 chr2:184005431(+) A-G intron -    22484847 chr2:184005501(+) A-G intron -    22484847 chr2:184007273(+) A-G intron -    22484847 chr2:184007274(+) A-G intron -    22484847 chr2:184007302(+) A-G intron -    22484847 chr2:184007309(+) A-G intron -    22484847 chr2:184007397(+) A-G intron -    22484847 chr2:184007460(+) A-G intron -    22484847 chr2:184007630(+) A-G intron -    22484847 chr2:184007692(+) A-G intron -    22484847 chr2:184007700(+) A-G intron -    22484847 chr2:184007718(+) A-G intron -    22484847 chr2:184010700(+) A-G intron -    22484847 chr2:184010802(+) A-G intron -    22484847 chr2:184010861(+) A-G intron -    22484847 chr2:184010916(+) A-G intron -    22484847 chr2:184011345(+) A-G intron -    22484847 chr2:184011442(+) A-G intron -    22484847 chr2:184011490(+) A-G intron -    22484847 chr2:184014735(+) A-G intron -    22484847 chr2:184014784(+) A-G intron -    22484847 chr2:184025292(+) A-G intron -    22484847 chr2:184025307(+) A-G intron -    22484847 chr2:184025354(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUP35	chr2:183989205-183989206(+) m6A CDS//exon//intron       24981863 chr2:183993021-183993022(+) m6A 5'UTR//CDS//exon       24981863 chr2:183996050-183996051(+) m6A 3'UTR//intron       - chr2:183996058-183996059(+) m6A 3'UTR//intron       - chr2:183998297-183998298(+) m6A 3'UTR//CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	NUP35	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: NUP35

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).