Basic Information:

  VIRBase ID:  

HHID00059702

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          TPRG1L:  NM_182752     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	TPRG1L
miRBase Accession/Entrez ID	MIMAT0002853	127262
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM79A//h-mover//mover

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TPRG1L	chr1:3543269(+) A-I      intronic chr1:3543217(+) A-I      intronic chr1:3543317(+) A-I      intronic chr1:3543597(+) A-I      intronic chr1:3543710(+) A-I      intronic chr1:3543794(+) A-I      intronic chr1:3543713(+) A-I      intronic chr1:3543167(+) A-I      intronic chr1:3543799(+) A-I      intronic chr1:3543243(+) A-I      intronic chr1:3543619(+) A-I      intronic chr1:3543795(+) A-I      intronic chr1:3543620(+) A-I      intronic chr1:3543405(+) A-I      intronic chr1:3543236(+) A-I      intronic chr1:3543378(+) A-I      intronic chr1:3543417(+) A-I      intronic chr1:3543714(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TPRG1L	chr1:3543236(+) A-G intron -    22484847 chr1:3543243(+) A-G intron -    22484847 chr1:3543378(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPRG1L	chr1:3541652-3541653(+) m6A CDS       24209618 chr1:3541661-3541662(+) m6A CDS       24209618 chr1:3541768-3541769(+) m6A CDS       24209618 chr1:3542290-3542291(+) m6A CDS//intron       24209618 chr1:3544095-3544096(+) m6A CDS       - chr1:3544122-3544123(+) m6A CDS       - chr1:3544171-3544172(+) m6A CDS       - chr1:3544199-3544200(+) m6A CDS       - chr1:3545247-3545248(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:3545372-3545373(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr1:3545394-3545395(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr1:3545408-3545409(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr1:3545528-3545529(+) m6A 3'UTR       24284625//22608085 chr1:3545544-3545545(+) Y 3'UTR       26075521 chr1:3545569-3545570(+) m6A 3'UTR       24284625 chr1:3546113-3546114(+) m6A 3'UTR       24981863 chr1:3546128-3546129(+) m6A 3'UTR       24981863 chr1:3546280-3546281(+) m6A 3'UTR       24209618 chr1:3546345-3546346(+) m6A 3'UTR       24209618 chr1:3546352-3546353(+) m6A 3'UTR       24209618 chr1:3546375-3546376(+) m6A 3'UTR       24209618 chr1:3546418-3546419(+) m6A 3'UTR       24209618//22608085 chr1:3546515-3546516(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:3546601-3546602(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr1:3546625-3546626(+) m6A 3'UTR       24209618//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	TPRG1L	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: TPRG1L

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).