Detail Information

Basic Information:


  VIRBase ID:  

HHID00059701

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           FAM210A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p FAM210A
miRBase
Accession/Entrez ID		 MIMAT0002853 125228
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C18orf19//HsT2329

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM210A
chr18:13710362(-) A-I      intronic
chr18:13724825(-) A-I      intronic
chr18:13678453(-) A-I      intronic
chr18:13724910(-) A-I      intronic
chr18:13711213(-) A-I      intronic
chr18:13710441(-) A-I      intronic
chr18:13710425(-) A-I      intronic
chr18:13710279(-) A-I      intronic
chr18:13665205(-) A-I      3'UTR
chr18:13665199(-) A-I      3'UTR
chr18:13711262(-) A-I      intronic
chr18:13710294(-) A-I      intronic
chr18:13665216(-) A-I      3'UTR
chr18:13710280(-) A-I      intronic
chr18:13672476(-) A-I      intronic
chr18:13698268(-) A-I      intronic
chr18:13699008(-) A-I      intronic
chr18:13711207(-) A-I      intronic
chr18:13710347(-) A-I      intronic
chr18:13684372(-) A-I      intronic
chr18:13670959(-) A-I      intronic
chr18:13678407(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM210A
chr18:13663468-13663469(-) m6A 3'UTR       27773535
chr18:13663500-13663501(-) m6A 3'UTR       27773535
chr18:13663528-13663529(-) m6A 3'UTR       27773535
chr18:13663611-13663612(-) m6A 3'UTR       27773535
chr18:13666283-13666284(-) m6A 3'UTR//exon       27773535
chr18:13666427-13666428(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr18:13666516-13666517(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666538-13666539(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666549-13666550(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666582-13666583(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr18:13666596-13666597(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//22608085
chr18:13666672-13666673(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr18:13681683-13681684(-) m6A CDS//exon//intron       24981863
chr18:13681691-13681692(-) m6A CDS//exon//intron       24981863
chr18:13681726-13681727(-) m6A CDS//exon//intron       24981863//27773535//22608085
chr18:13681763-13681764(-) m6A CDS//exon//intron       24981863//27773535//22608085
chr18:13681917-13681918(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13681974-13681975(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13681995-13681996(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682019-13682020(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682030-13682031(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682054-13682055(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682095-13682096(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr18:13687761-13687762(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr18:13687788-13687789(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr18:13687840-13687841(-) m6A 5'UTR//intron       24209618//27371828
chr18:13726437-13726438(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//27773536//22575960
chr18:13726589-13726590(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
FAM210A
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: FAM210A

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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