Detail Information

Basic Information:


  VIRBase ID:  

HHID00059699

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           FRMD6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p FRMD6
miRBase
Accession/Entrez ID		 MIMAT0002853 122786
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - c14_5320//C14orf31//EX1//Willin

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FRMD6
chr14:52112782(+) A-I      intronic
chr14:52101720(+) A-I      intronic
chr14:52112853(+) A-I      intronic
chr14:51981523(+) A-I      intronic
chr14:52095366(+) A-I      intronic
chr14:51976484(+) A-I      intronic
chr14:52124940(+) A-I      intronic
chr14:51981517(+) A-I      intronic
chr14:52058309(+) A-I      intronic
chr14:52112442(+) A-I      intronic
chr14:52027227(+) A-I      intronic
chr14:51999007(+) A-I      intronic
chr14:51987516(+) A-I      intronic
chr14:52107951(+) A-I      intronic
chr14:52058390(+) A-I      intronic
chr14:52058316(+) A-I      intronic
chr14:52058330(+) A-I      intronic
chr14:52027272(+) A-I      intronic
chr14:51976554(+) A-I      intronic
chr14:52058469(+) A-I      intronic
chr14:51976587(+) A-I      intronic
chr14:52089671(+) A-I      intronic
chr14:52135204(+) A-I      intronic
chr14:52089623(+) A-I      intronic
chr14:51976544(+) A-I      intronic
chr14:52133581(+) A-I      intronic
chr14:51976606(+) A-I      intronic
chr14:52103756(+) A-I      intronic
chr14:51998899(+) A-I      intronic
chr14:52058441(+) A-I      intronic
chr14:52016587(+) A-I      intronic
chr14:52135088(+) A-I      intronic
chr14:52016453(+) A-I      intronic
chr14:52135105(+) A-I      intronic
chr14:52016443(+) A-I      intronic
chr14:52135089(+) A-I      intronic
chr14:52058470(+) A-I      intronic
chr14:52135198(+) A-I      intronic
chr14:52123413(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FRMD6
chr14:52112919(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FRMD6
chr14:52042554-52042555(+) m6A exon//intron       24209618
chr14:52042560-52042561(+) m6A exon//intron       24209618
chr14:52042587-52042588(+) m6A exon//intron       24209618
chr14:52042608-52042609(+) m6A exon//intron       24209618
chr14:52042653-52042654(+) m6A exon//intron       24209618
chr14:52042760-52042761(+) m6A exon//intron       24209618
chr14:52042783-52042784(+) m6A exon//intron       24209618
chr14:52042793-52042794(+) m6A exon//intron       24209618
chr14:52042852-52042853(+) m6A exon//intron       24209618
chr14:52042877-52042878(+) m6A exon//intron       24209618
chr14:52118702-52118703(+) m6A 5'UTR//intron       24981863
chr14:52118720-52118721(+) m6A 5'UTR//intron       24981863
chr14:52118726-52118727(+) m6A 5'UTR//intron       24981863
chr14:52156415-52156416(+) m6A 5'UTR//exon       24981863
chr14:52156429-52156430(+) m6A 5'UTR//exon       24981863
chr14:52156494-52156495(+) m6A 5'UTR       24981863
chr14:52156513-52156514(+) m6A 5'UTR       24981863
chr14:52156549-52156550(+) m6A 5'UTR       24981863
chr14:52156558-52156559(+) m6A CDS       24981863
chr14:52182125-52182126(+) m6A CDS//exon       24284625
chr14:52186814-52186815(+) m6A 5'UTR//CDS//exon       -
chr14:52186826-52186827(+) m6A CDS//exon       -
chr14:52186878-52186879(+) m6A CDS//exon       -
chr14:52186946-52186947(+) m6A CDS//exon       24981863
chr14:52186961-52186962(+) m6A CDS//exon       24981863
chr14:52186976-52186977(+) m6A CDS//exon       24981863
chr14:52187014-52187015(+) m6A CDS//exon       24981863
chr14:52187078-52187079(+) m6A CDS//exon       -
chr14:52187093-52187094(+) m6A CDS//exon       -
chr14:52188738-52188739(+) m6A CDS//exon       24209618
chr14:52188762-52188763(+) m6A CDS//exon       24209618
chr14:52188790-52188791(+) m6A CDS//exon       24284625//24209618//22608085
chr14:52192543-52192544(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:52194476-52194477(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:52194483-52194484(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:52194524-52194525(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr14:52194538-52194539(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr14:52194568-52194569(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr14:52194605-52194606(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr14:52194687-52194688(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:52194850-52194851(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr14:52194887-52194888(+) m6A 3'UTR//exon       24209618//24981863//22608085
chr14:52194901-52194902(+) m6A 3'UTR//exon       24209618//24981863//22608085
chr14:52194937-52194938(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085
chr14:52194959-52194960(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085
chr14:52195261-52195262(+) m6A 3'UTR//exon       24209618//24981863//22608085
chr14:52195345-52195346(+) m6A 3'UTR//exon       24209618//24981863//22608085
chr14:52195505-52195506(+) m6A 3'UTR//exon       24209618
chr14:52195521-52195522(+) m6A 3'UTR//exon       24209618
chr14:52196007-52196008(+) m6A 3'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
FRMD6
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: FRMD6

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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