Basic Information:

  VIRBase ID:  

HHID00059654

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:  MIMAT0002853          SLC35F5:  NM_001330316     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519d-3p	SLC35F5
miRBase Accession/Entrez ID	MIMAT0002853	80255
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519d-3p	rs1031566931 chr19:53713420    T/A rs116796400 chr19:53713416    A/G rs1177367352 chr19:53713409    T/A rs1362826944 chr19:53713419    G/T rs1443130720 chr19:53713413    T/A rs748935087 chr19:53713417    G/T rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA rs754470034 chr19:53713415    T/TACCAA rs754470034 chr19:53713415    T/TA rs754629979 chr19:53713421    G/T rs755601254 chr19:53713414    T/A rs752048127 chr19:53713406    G/T rs764695340 chr19:53713405    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35F5	chr2:114510957(-) A-I      intronic chr2:114499034(-) A-I      intronic chr2:114511820(-) A-I      intronic chr2:114498170(-) A-I      intronic chr2:114499015(-) A-I      intronic chr2:114498167(-) A-I      intronic chr2:114498159(-) A-I      intronic chr2:114498977(-) A-I      intronic chr2:114498971(-) A-I      intronic chr2:114498129(-) A-I      intronic chr2:114499035(-) A-I      intronic chr2:114498963(-) A-I      intronic chr2:114499385(-) A-I      intronic chr2:114498962(-) A-I      intronic chr2:114510893(-) A-I      intronic chr2:114510894(-) A-I      intronic chr2:114499012(-) A-I      intronic chr2:114498135(-) A-I      intronic chr2:114475822(-) A-I      intronic chr2:114510888(-) A-I      intronic chr2:114498989(-) A-I      intronic chr2:114510924(-) A-I      intronic chr2:114498141(-) A-I      intronic chr2:114510932(-) A-I      intronic chr2:114510948(-) A-I      intronic chr2:114475826(-) A-I      intronic chr2:114505910(-) A-I      intronic chr2:114506551(-) A-I      intronic chr2:114506560(-) A-I      intronic chr2:114506574(-) A-I      intronic chr2:114506660(-) A-I      intronic chr2:114506834(-) A-I      intronic chr2:114506835(-) A-I      intronic chr2:114506968(-) A-I      intronic chr2:114506994(-) A-I      intronic chr2:114507038(-) A-I      intronic chr2:114507062(-) A-I      intronic chr2:114508599(-) A-I      intronic chr2:114510818(-) A-I      intronic chr2:114510821(-) A-I      intronic chr2:114510841(-) A-I      intronic chr2:114510845(-) A-I      intronic chr2:114510853(-) A-I      intronic chr2:114510864(-) A-I      intronic chr2:114510877(-) A-I      intronic chr2:114510884(-) A-I      intronic chr2:114510967(-) A-I      intronic chr2:114511043(-) A-I      intronic chr2:114511785(-) A-I      intronic chr2:114505938(-) A-I      intronic chr2:114475776(-) A-I      intronic chr2:114475808(-) A-I      intronic chr2:114476244(-) A-I      intronic chr2:114476250(-) A-I      intronic chr2:114476260(-) A-I      intronic chr2:114476272(-) A-I      intronic chr2:114476289(-) A-I      intronic chr2:114476290(-) A-I      intronic chr2:114479614(-) A-I      intronic chr2:114479620(-) A-I      intronic chr2:114479846(-) A-I      intronic chr2:114498200(-) A-I      intronic chr2:114498342(-) A-I      intronic chr2:114498360(-) A-I      intronic chr2:114498368(-) A-I      intronic chr2:114498392(-) A-I      intronic chr2:114499107(-) A-I      intronic chr2:114499113(-) A-I      intronic chr2:114499218(-) A-I      intronic chr2:114504305(-) A-I      intronic chr2:114504387(-) A-I      intronic chr2:114504422(-) A-I      intronic chr2:114504458(-) A-I      intronic chr2:114504460(-) A-I      intronic chr2:114505804(-) A-I      intronic chr2:114475829(-) A-I      intronic chr2:114510852(-) A-I      intronic chr2:114493748(-) A-I      intronic chr2:114506995(-) A-I      intronic chr2:114511701(-) A-I      intronic chr2:114504457(-) A-I      intronic chr2:114510970(-) A-I      intronic chr2:114499033(-) A-I      intronic chr2:114475789(-) A-I      intronic chr2:114506905(-) A-I      intronic chr2:114505999(-) A-I      intronic chr2:114505797(-) A-I      intronic chr2:114498469(-) A-I      intronic chr2:114511624(-) A-I      intronic chr2:114508610(-) A-I      intronic chr2:114511745(-) A-I      intronic chr2:114498386(-) A-I      intronic chr2:114505638(-) A-I      intronic chr2:114509667(-) A-I      intronic chr2:114498233(-) A-I      intronic chr2:114511757(-) A-I      intronic chr2:114476333(-) A-I      intronic chr2:114475769(-) A-I      intronic chr2:114498203(-) A-I      intronic chr2:114475897(-) A-I      intronic chr2:114505412(-) A-I      intronic chr2:114510933(-) A-I      intronic chr2:114499019(-) A-I      intronic chr2:114475892(-) A-I      intronic chr2:114502233(-) A-I      intronic chr2:114510923(-) A-I      intronic chr2:114505871(-) A-I      intronic chr2:114499122(-) A-I      intronic chr2:114508505(-) A-I      intronic chr2:114507013(-) A-I      intronic chr2:114475806(-) A-I      intronic chr2:114510931(-) A-I      intronic chr2:114475715(-) A-I      intronic chr2:114504743(-) A-I      intronic chr2:114506019(-) A-I      intronic chr2:114507070(-) A-I      intronic chr2:114511743(-) A-I      intronic chr2:114507029(-) A-I      intronic chr2:114505903(-) A-I      intronic chr2:114505839(-) A-I      intronic chr2:114506991(-) A-I      intronic chr2:114504801(-) A-I      intronic chr2:114475841(-) A-I      intronic chr2:114508504(-) A-I      intronic chr2:114511020(-) A-I      intronic chr2:114511755(-) A-I      intronic chr2:114475830(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC35F5	chr2:114475892(-) A-I intron -    22327324 chr2:114506991(-) A-I intron -    21960545 chr2:114506994(-) A-I intron -    21960545 chr2:114498071(-) A-G intron -    22484847 chr2:114498530(-) A-G intron -    22484847 chr2:114498534(-) A-G intron -    22484847 chr2:114498972(-) A-G intron -    22484847 chr2:114498982(-) A-G intron -    22484847 chr2:114498983(-) A-G intron -    22484847 chr2:114475829(-) A-G intron -    22484847 chr2:114475892(-) A-G intron -    22484847 chr2:114475897(-) A-G intron -    22484847 chr2:114493852(-) G-T intron -    22484847 chr2:114498386(-) A-G intron -    22484847 chr2:114498469(-) A-G intron -    22484847 chr2:114498475(-) A-G intron -    22484847 chr2:114499033(-) A-G intron -    22484847 chr2:114499122(-) A-G intron -    22484847 chr2:114504506(-) C-T intron -    22484847 chr2:114505503(-) A-G intron -    22484847 chr2:114505638(-) A-G intron -    22484847 chr2:114505903(-) A-G intron -    22484847 chr2:114505907(-) A-G intron -    22484847 chr2:114505999(-) A-G intron -    22484847 chr2:114506448(-) A-G intron -    22484847 chr2:114506575(-) A-G intron -    22484847 chr2:114506905(-) A-G intron -    22484847 chr2:114506991(-) A-G intron -    22484847 chr2:114507070(-) A-G intron -    22484847 chr2:114508610(-) A-G intron -    22484847 chr2:114509667(-) A-G intron -    22484847 chr2:114510852(-) A-G intron -    22484847 chr2:114510920(-) A-G intron -    22484847 chr2:114510926(-) A-G intron -    22484847 chr2:114510996(-) A-G intron -    22484847 chr2:114511624(-) A-G intron -    22484847 chr2:114511701(-) A-G intron -    22484847 chr2:114511742(-) G-A intron -    22484847 chr2:114511743(-) A-G intron -    22484847 chr2:114511745(-) A-G intron -    22484847 chr2:114511755(-) A-G intron -    22484847 chr2:114511757(-) A-G intron -    22484847 chr2:114511758(-) A-G intron -    22484847 chr2:114511784(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35F5	chr2:114462713-114462714(-) m6A exon       27773535 chr2:114462761-114462762(-) m6A exon       27773535 chr2:114462791-114462792(-) m6A exon       27773535 chr2:114471300-114471301(-) m6A 3'UTR//intron       24981863 chr2:114472392-114472393(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472465-114472466(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472497-114472498(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472547-114472548(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472668-114472669(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472711-114472712(-) Y 3'UTR//intron       26075521 chr2:114472743-114472744(-) m6A 3'UTR//intron       24981863//22608085 chr2:114472759-114472760(-) m6A 3'UTR//intron       24981863//22608085 chr2:114513835-114513836(-) m6A 5'UTR//intron       27773536 chr2:114513904-114513905(-) m6A 5'UTR//intron       27773536 chr2:114514272-114514273(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519d-3p	Exosome Serum     18589210 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts     -
	SLC35F5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519d-3p
Interactor2: SLC35F5

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).