Detail Information

Basic Information:


  VIRBase ID:  

HHID00059651

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           UXS1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p UXS1
miRBase
Accession/Entrez ID		 MIMAT0002853 80146
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SDR6E1//UGD

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UXS1
chr2:106801118(-) A-I      intronic
chr2:106759695(-) A-I      intronic
chr2:106759813(-) A-I      intronic
chr2:106777654(-) A-I      intronic
chr2:106783267(-) A-I      intronic
chr2:106758510(-) A-I      intronic
chr2:106793933(-) A-I      intronic
chr2:106800536(-) A-I      intronic
chr2:106800523(-) A-I      intronic
chr2:106804266(-) A-I      intronic
chr2:106793730(-) A-I      intronic
chr2:106758395(-) A-I      intronic
chr2:106793927(-) A-I      intronic
chr2:106783274(-) A-I      intronic
chr2:106759700(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UXS1
chr2:106800523(-) A-G intron -    22484847
chr2:106800536(-) A-G intron -    22484847
chr2:106807022(-) T-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UXS1
chr2:106710131-106710132(-) m6A 3'UTR//exon       27773535
chr2:106710143-106710144(-) m6A 3'UTR//exon       27773535
chr2:106710305-106710306(-) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710373-106710374(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710395-106710396(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710457-106710458(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710464-106710465(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710480-106710481(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710495-106710496(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710526-106710527(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr2:106710562-106710563(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr2:106710590-106710591(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr2:106713213-106713214(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr2:106713218-106713219(-) m6A CDS//exon       24209618//24981863//27773535//27371828//22608085
chr2:106713285-106713286(-) m6A exon//intron       24981863//27773535
chr2:106717541-106717542(-) m6A CDS//exon       27773535
chr2:106721271-106721272(-) m6A CDS//exon       27773535
chr2:106761692-106761693(-) m6A 5'UTR//CDS//exon//intron       -
chr2:106761700-106761701(-) m6A 5'UTR//CDS//exon//intron       -
chr2:106761746-106761747(-) m6A 5'UTR//CDS//exon//intron       -
chr2:106761781-106761782(-) m6A 5'UTR//CDS//exon//intron       27773535
chr2:106775606-106775607(-) m6A exon//intron       27773535
chr2:106775621-106775622(-) m6A exon//intron       27773535
chr2:106776534-106776535(-) m6A exon//intron       22608085
chr2:106776587-106776588(-) m6A exon//intron       22608085
chr2:106776592-106776593(-) m6A exon//intron       22608085
chr2:106776707-106776708(-) m6A exon//intron       27773535//27371828//22608085
chr2:106776738-106776739(-) m6A exon//intron       27773535//27371828//22608085
chr2:106776751-106776752(-) m6A exon//intron       27773535//27371828//22608085
chr2:106776839-106776840(-) m6A exon//intron       27371828//22608085
chr2:106780157-106780158(-) m6A CDS//exon//intron       27773535
chr2:106781218-106781219(-) m6A 5'UTR//CDS//exon//intron       27773535
chr2:106810715-106810716(-) m6A 5'UTR//exon       24209618//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
UXS1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: UXS1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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