Detail Information

Basic Information:


  VIRBase ID:  

HHID00059570

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           TNFRSF21:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p TNFRSF21
miRBase
Accession/Entrez ID		 MIMAT0002853 27242
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BM-018//CD358//DR6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TNFRSF21
chr6:47225939(-) A-I      intronic
chr6:47249277(-) A-I      intronic
chr6:47249265(-) A-I      intronic
chr6:47225933(-) A-I      intronic
chr6:47211214(-) A-I      intronic
chr6:47211358(-) A-I      intronic
chr6:47250068(-) A-I      intronic
chr6:47249290(-) A-I      intronic
chr6:47249281(-) A-I      intronic
chr6:47249185(-) A-I      intronic
chr6:47249189(-) A-I      intronic
chr6:47211291(-) A-I      intronic
chr6:47227392(-) A-I      intronic
chr6:47249169(-) A-I      intronic
chr6:47250060(-) A-I      intronic
chr6:47211890(-) A-I      intronic
chr6:47275309(-) A-I      intronic
chr6:47265344(-) A-I      intronic
chr6:47224165(-) A-I      intronic
chr6:47262539(-) A-I      intronic
chr6:47211278(-) A-I      intronic
chr6:47211292(-) A-I      intronic
chr6:47223240(-) A-I      intronic
chr6:47226371(-) A-I      intronic
chr6:47265415(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TNFRSF21
chr6:47224165(-) A-G intron -    22484847
chr6:47226348(-) A-G intron -    22484847
chr6:47226371(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNFRSF21
chr6:47199283-47199284(-) m6A 3'UTR       24981863//27773535
chr6:47199328-47199329(-) m6A 3'UTR       24981863//27773535
chr6:47199369-47199370(-) m6A 3'UTR       24981863//27773535
chr6:47199460-47199461(-) m6A 3'UTR       27773535
chr6:47199658-47199659(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr6:47199690-47199691(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr6:47199696-47199697(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr6:47199821-47199822(-) m6A 3'UTR       24981863
chr6:47200498-47200499(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr6:47200534-47200535(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr6:47200544-47200545(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr6:47200591-47200592(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:47200600-47200601(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:47200693-47200694(-) m6A CDS       24284625//24209618//24981863//27773535//22575960
chr6:47200720-47200721(-) m6A CDS       24284625//24209618//24981863//27773535
chr6:47202506-47202507(-) m6A CDS       24284625//27773535
chr6:47202512-47202513(-) m6A CDS       24284625//27773535
chr6:47202556-47202557(-) m6A CDS       24284625//27773535
chr6:47202619-47202620(-) m6A CDS       24284625//24981863//27773535
chr6:47202627-47202628(-) m6A CDS       24284625//24981863//27773535
chr6:47221001-47221002(-) m6A CDS       24284625//24981863//27773535
chr6:47221101-47221102(-) m6A CDS       24284625//27773535
chr6:47251708-47251709(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535
chr6:47251790-47251791(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22608085
chr6:47251900-47251901(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22608085
chr6:47251905-47251906(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27773536//22608085
chr6:47251914-47251915(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27773536//22608085
chr6:47251995-47251996(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22608085
chr6:47252035-47252036(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22608085
chr6:47252045-47252046(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22608085
chr6:47252050-47252051(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22608085
chr6:47252096-47252097(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27773536//22608085
chr6:47252127-47252128(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536//22608085
chr6:47252161-47252162(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536
chr6:47253715-47253716(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27773536
chr6:47253808-47253809(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536//22575960//22608085
chr6:47253817-47253818(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536//22575960//22608085
chr6:47253840-47253841(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536//22575960//22608085
chr6:47253855-47253856(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27773536//22575960//22608085
chr6:47253940-47253941(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:47253946-47253947(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:47254144-47254145(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:47254207-47254208(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:47254295-47254296(-) m6A CDS       24284625//24209618//27773535
chr6:47277240-47277241(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
TNFRSF21
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: TNFRSF21

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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