Detail Information

Basic Information:


  VIRBase ID:  

HHID00059547

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           MLXIP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p MLXIP
miRBase
Accession/Entrez ID		 MIMAT0002853 22877
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bHLHe36//MIR//MONDOA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MLXIP
chr12:122598718(+) A-I      intronic
chr12:122629257(+) A-I      3'UTR
chr12:122629256(+) A-I      3'UTR
chr12:122629247(+) A-I      3'UTR
chr12:122629213(+) A-I      3'UTR
chr12:122592768(+) A-I      intronic
chr12:122592754(+) A-I      intronic
chr12:122592759(+) A-I      intronic
chr12:122592756(+) A-I      intronic
chr12:122592755(+) A-I      intronic
chr12:122597838(+) A-I      intronic
chr12:122528192(+) A-I      intronic
chr12:122527073(+) A-I      intronic
chr12:122595413(+) A-I      intronic
chr12:122587574(+) A-I      intronic
chr12:122582003(+) A-I      intronic
chr12:122581997(+) A-I      intronic
chr12:122523366(+) A-I      intronic
chr12:122521572(+) A-I      intronic
chr12:122519526(+) A-I      intronic
chr12:122581986(+) A-I      intronic
chr12:122580764(+) A-I      intronic
chr12:122580742(+) A-I      intronic
chr12:122528335(+) A-I      intronic
chr12:122607036(+) A-I      intronic
chr12:122604833(+) A-I      intronic
chr12:122530073(+) A-I      intronic
chr12:122604019(+) A-I      intronic
chr12:122603995(+) A-I      intronic
chr12:122603994(+) A-I      intronic
chr12:122528206(+) A-I      intronic
chr12:122597927(+) A-I      intronic
chr12:122597914(+) A-I      intronic
chr12:122582046(+) A-I      intronic
chr12:122594758(+) A-I      intronic
chr12:122594790(+) A-I      intronic
chr12:122603137(+) A-I      intronic
chr12:122621608(+) A-I      intronic
chr12:122608386(+) A-I      intronic
chr12:122600022(+) A-I      intronic
chr12:122597860(+) A-I      intronic
chr12:122599976(+) A-I      intronic
chr12:122629177(+) A-I      3'UTR
chr12:122530279(+) A-I      intronic
chr12:122597855(+) A-I      intronic
chr12:122520750(+) A-I      intronic
chr12:122530233(+) A-I      intronic
chr12:122607301(+) A-I      intronic
chr12:122603616(+) A-I      intronic
chr12:122529394(+) A-I      intronic
chr12:122520989(+) A-I      intronic
chr12:122608380(+) A-I      intronic
chr12:122616731(+) A-I      intronic
chr12:122597830(+) A-I      intronic
chr12:122618842(+) A-I      intronic
chr12:122596998(+) A-I      intronic
chr12:122621097(+) A-I      intronic
chr12:122599970(+) A-I      intronic
chr12:122581987(+) A-I      intronic
chr12:122593777(+) A-I      intronic
chr12:122529371(+) A-I      intronic
chr12:122528342(+) A-I      intronic
chr12:122583763(+) A-I      intronic
chr12:122582060(+) A-I      intronic
chr12:122521450(+) A-I      intronic
chr12:122594767(+) A-I      intronic
chr12:122526834(+) A-I      intronic
chr12:122599977(+) A-I      intronic
chr12:122599324(+) A-I      intronic
chr12:122592795(+) A-I      intronic
chr12:122621101(+) A-I      intronic
chr12:122519473(+) A-I      intronic
chr12:122529340(+) A-I      intronic
chr12:122529348(+) A-I      intronic
chr12:122530243(+) A-I      intronic
chr12:122592821(+) A-I      intronic
chr12:122520796(+) A-I      intronic
chr12:122587232(+) A-I      intronic
chr12:122604903(+) A-I      intronic
chr12:122526968(+) A-I      intronic
chr12:122602640(+) A-I      intronic
chr12:122609323(+) A-I      intronic
chr12:122592840(+) A-I      intronic
chr12:122629178(+) A-I      3'UTR
chr12:122628947(+) A-I      3'UTR
chr12:122629003(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MLXIP
chr12:122583806(+) C-A intron -    22484847
chr12:122597830(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MLXIP
chr12:122516859-122516860(+) m6A CDS       24209618
chr12:122615408-122615409(+) m6A CDS//exon       24284625
chr12:122615424-122615425(+) m6A CDS//exon       24284625//22575960
chr12:122615450-122615451(+) m6A CDS//exon       24284625//22575960
chr12:122615459-122615460(+) m6A CDS//exon       24284625//22575960
chr12:122617131-122617132(+) m6A 5'UTR//intron       24284625//24209618//24981863
chr12:122618001-122618002(+) m6A CDS//exon       24284625//24209618//25456834//24981863
chr12:122618014-122618015(+) m6A CDS//exon       24284625//24209618//25456834//24981863
chr12:122618021-122618022(+) m6A CDS//exon       24284625//24209618//25456834//24981863
chr12:122618042-122618043(+) m6A CDS//exon       24284625//24209618//25456834//24981863
chr12:122618183-122618184(+) m6A CDS//exon       24284625//24209618//24981863
chr12:122618427-122618428(+) m6A CDS//exon       24284625
chr12:122618487-122618488(+) m6A CDS//exon       24284625
chr12:122618551-122618552(+) m6A CDS//exon//intron       24284625
chr12:122618610-122618611(+) m6A CDS//exon//intron       24284625
chr12:122622021-122622022(+) m6A CDS//exon       -
chr12:122622030-122622031(+) m6A CDS//exon       -
chr12:122622090-122622091(+) m6A CDS//exon       -
chr12:122622741-122622742(+) m6A CDS//exon       -
chr12:122625597-122625598(+) m6A CDS       24284625
chr12:122626288-122626289(+) m6A CDS       24284625
chr12:122626397-122626398(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960
chr12:122626560-122626561(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr12:122626574-122626575(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr12:122626890-122626891(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122626962-122626963(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122626992-122626993(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627001-122627002(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627003-122627004(+) Cm 3'UTR       -
chr12:122627111-122627112(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627228-122627229(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627258-122627259(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627319-122627320(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627325-122627326(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627336-122627337(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:122627391-122627392(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr12:122627460-122627461(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr12:122628057-122628058(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr12:122628156-122628157(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr12:122628268-122628269(+) m6A 3'UTR       24284625//24209618//24981863
chr12:122628589-122628590(+) Y 3'UTR       26075521
chr12:122629354-122629355(+) m6A 3'UTR       24981863
chr12:122629423-122629424(+) m6A 3'UTR       24981863
chr12:122629475-122629476(+) m6A 3'UTR       24981863
chr12:122630866-122630867(+) m6A 3'UTR       24284625
chr12:122630889-122630890(+) m6A 3'UTR       24284625
chr12:122630911-122630912(+) m6A 3'UTR       24284625
chr12:122630974-122630975(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
MLXIP
Chromatin K562 cells     -
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: MLXIP

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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