Detail Information

Basic Information:


  VIRBase ID:  

HHID00059438

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           MTF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p MTF1
miRBase
Accession/Entrez ID		 MIMAT0002853 4520
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MTF-1//ZRF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MTF1
chr1:38294043(-) A-I      intronic
chr1:38294042(-) A-I      intronic
chr1:38322219(-) A-I      intronic
chr1:38322229(-) A-I      intronic
chr1:38322234(-) A-I      intronic
chr1:38294062(-) A-I      intronic
chr1:38321460(-) A-I      intronic
chr1:38321547(-) A-I      intronic
chr1:38321583(-) A-I      intronic
chr1:38321970(-) A-I      intronic
chr1:38322088(-) A-I      intronic
chr1:38322127(-) A-I      intronic
chr1:38322244(-) A-I      intronic
chr1:38290153(-) A-I      intronic
chr1:38290201(-) A-I      intronic
chr1:38290207(-) A-I      intronic
chr1:38290262(-) A-I      intronic
chr1:38292507(-) A-I      intronic
chr1:38292565(-) A-I      intronic
chr1:38294073(-) A-I      intronic
chr1:38294079(-) A-I      intronic
chr1:38295424(-) A-I      intronic
chr1:38301541(-) A-I      intronic
chr1:38308767(-) A-I      intronic
chr1:38311300(-) A-I      intronic
chr1:38318496(-) A-I      intronic
chr1:38318504(-) A-I      intronic
chr1:38318506(-) A-I      intronic
chr1:38294887(-) A-I      intronic
chr1:38290125(-) A-I      intronic
chr1:38311341(-) A-I      intronic
chr1:38292535(-) A-I      intronic
chr1:38322444(-) A-I      intronic
chr1:38321463(-) A-I      intronic
chr1:38321987(-) A-I      intronic
chr1:38321441(-) A-I      intronic
chr1:38321466(-) A-I      intronic
chr1:38321952(-) A-I      intronic
chr1:38318592(-) A-I      intronic
chr1:38290284(-) A-I      intronic
chr1:38292085(-) A-I      intronic
chr1:38278709(-) A-I      3'UTR
chr1:38294204(-) A-I      intronic
chr1:38292539(-) A-I      intronic
chr1:38292049(-) A-I      intronic
chr1:38322014(-) A-I      intronic
chr1:38292166(-) A-I      intronic
chr1:38319844(-) A-I      intronic
chr1:38295416(-) A-I      intronic
chr1:38321543(-) A-I      intronic
chr1:38322350(-) A-I      intronic
chr1:38322004(-) A-I      intronic
chr1:38315437(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MTF1
chr1:38278739(-) G-C exon 3'UTR    21725310
chr1:38278739(-) G-A exon 3'UTR    21725310
chr1:38290284(-) A-G intron -    22484847
chr1:38292049(-) A-G intron -    22484847
chr1:38292535(-) A-G intron -    22484847
chr1:38292539(-) A-G intron -    22484847
chr1:38294204(-) A-G intron -    22484847
chr1:38295416(-) A-G intron -    22484847
chr1:38321441(-) A-G intron -    22484847
chr1:38321543(-) A-G intron -    22484847
chr1:38322014(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MTF1
chr1:38275434-38275435(-) m6A 3'UTR       24981863
chr1:38275442-38275443(-) m6A 3'UTR       24981863
chr1:38275496-38275497(-) m6A 3'UTR       24981863
chr1:38275503-38275504(-) m6A 3'UTR       24981863
chr1:38275511-38275512(-) m6A 3'UTR       24981863
chr1:38276414-38276415(-) m6A 3'UTR       24981863
chr1:38276503-38276504(-) m6A 3'UTR       24981863//27773535
chr1:38277280-38277281(-) m6A 3'UTR       24981863
chr1:38277311-38277312(-) m6A 3'UTR       24981863
chr1:38277352-38277353(-) m6A 3'UTR       24981863
chr1:38280284-38280285(-) m6A 3'UTR       27773535
chr1:38280341-38280342(-) m6A 3'UTR       27773535
chr1:38280521-38280522(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280529-38280530(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280574-38280575(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280602-38280603(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280611-38280612(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280618-38280619(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280636-38280637(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:38280889-38280890(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr1:38280938-38280939(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38280944-38280945(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38280952-38280953(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38280962-38280963(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38281040-38281041(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:38281150-38281151(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:38281188-38281189(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22608085
chr1:38287798-38287799(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:38287805-38287806(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:38287847-38287848(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr1:38287852-38287853(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr1:38287956-38287957(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr1:38288065-38288066(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38288209-38288210(-) m6A CDS       24284625//24209618//24981863//27773535
chr1:38289384-38289385(-) m6A CDS       27773535
chr1:38289470-38289471(-) m6A CDS       27773535
chr1:38300789-38300790(-) m6A CDS       27773535
chr1:38300845-38300846(-) m6A CDS       27773535
chr1:38300879-38300880(-) m6A CDS       27773535
chr1:38301363-38301364(-) m6A CDS       27773535
chr1:38304321-38304322(-) m6A CDS       27773535
chr1:38305751-38305752(-) m6A CDS       27773535
chr1:38305763-38305764(-) m6A CDS       27773535
chr1:38322936-38322937(-) m6A CDS       27773535
chr1:38323007-38323008(-) m6A CDS       24284625//24981863//27773535
chr1:38323123-38323124(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323135-38323136(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323169-38323170(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323191-38323192(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323206-38323207(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323228-38323229(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323310-38323311(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323321-38323322(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38323332-38323333(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:38324171-38324172(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
MTF1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: MTF1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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