Detail Information

Basic Information:


  VIRBase ID:  

HHID00059433

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519d-3p:           MCL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-519d-3p MCL1
miRBase
Accession/Entrez ID		 MIMAT0002853 4170
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bcl2-L-3//BCL2L3//EAT//Mcl-1//MCL1-ES//mcl1/EAT//MCL1L//MCL1S//TM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-519d-3p
rs1031566931 chr19:53713420    T/A
rs116796400 chr19:53713416    A/G
rs1177367352 chr19:53713409    T/A
rs1362826944 chr19:53713419    G/T
rs1443130720 chr19:53713413    T/A
rs748935087 chr19:53713417    G/T
rs752635598 chr19:53713417    G/GTGTTACCCAAAGTGTTACCCAAACGTAACCCAA
rs754470034 chr19:53713415    T/TACCAA
rs754470034 chr19:53713415    T/TA
rs754629979 chr19:53713421    G/T
rs755601254 chr19:53713414    T/A
rs752048127 chr19:53713406    G/T
rs764695340 chr19:53713405    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCL1
chr1:150547166-150547167(-) Y 3'UTR       25219674
chr1:150547424-150547425(-) m6A 3'UTR       24981863//26404942
chr1:150547472-150547473(-) m6A 3'UTR       26404942
chr1:150547590-150547591(-) Y 3'UTR       25219674
chr1:150547632-150547633(-) m6A 3'UTR       26404942
chr1:150547747-150547748(-) m6A 3'UTR       26404942
chr1:150547800-150547801(-) m6A 3'UTR       26404942
chr1:150547820-150547821(-) m6A 3'UTR       26404942
chr1:150547851-150547852(-) m6A 3'UTR       26404942
chr1:150547875-150547876(-) m6A 3'UTR       26404942
chr1:150547902-150547903(-) m6A 3'UTR       26404942
chr1:150547985-150547986(-) m6A 3'UTR       26404942
chr1:150548068-150548069(-) m6A 3'UTR       26404942
chr1:150548154-150548155(-) m6A 3'UTR       26404942
chr1:150548172-150548173(-) m6A 3'UTR       26404942
chr1:150548209-150548210(-) m6A 3'UTR       26404942
chr1:150548222-150548223(-) m6A 3'UTR       26404942
chr1:150548589-150548590(-) m6A 3'UTR       24981863//26404942
chr1:150548638-150548639(-) m6A 3'UTR       26404942
chr1:150549312-150549313(-) m6A 3'UTR       26404942
chr1:150549407-150549408(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:150549533-150549534(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549538-150549539(-) Y 3'UTR//exon       25219674
chr1:150549553-150549554(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549588-150549589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549619-150549620(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549692-150549693(-) Tm 3'UTR//exon       -
chr1:150549779-150549780(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549797-150549798(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549935-150549936(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550731-150550732(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550744-150550745(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550754-150550755(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550791-150550792(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550810-150550811(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550817-150550818(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550827-150550828(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550876-150550877(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550948-150550949(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550953-150550954(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550989-150550990(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551007-150551008(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551235-150551236(-) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551372-150551373(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551422-150551423(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551449-150551450(-) Y CDS       26075521
chr1:150551791-150551792(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:150551973-150551974(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150552109-150552110(-) m6A 5'UTR       -
chr1:150552124-150552125(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-519d-3p
Exosome Serum     18589210
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -
MCL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-519d-3p
Interactor2: MCL1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

Starting a new search, please wait ...