Basic Information:

  VIRBase ID:  

HHID00058680

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:  MIMAT0002807          PHACTR1:  NM_001374583     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-491-5p	PHACTR1
miRBase Accession/Entrez ID	MIMAT0002807	221692
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DEE70//dJ257A7.2//EIEE70//RPEL//RPEL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-491-5p	rs1302649663 chr9:20716133    TC/T rs1443323273 chr9:20716132    T/G rs563573084 chr9:20716129    C/T rs760801072 chr9:20716135    C/T rs768108997 chr9:20716130    C/T rs773685607 chr9:20716134    C/G rs773685607 chr9:20716134    C/T rs774721604 chr9:20716128    A/T rs1441505194 chr9:20716126    G/A rs768906975 chr9:20716122    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PHACTR1	chr6:13056525(+) A-I      intronic chr6:13144851(+) A-I      intronic chr6:13144857(+) A-I      intronic chr6:13144877(+) A-I      intronic chr6:13173971(+) A-I      intronic chr6:13177341(+) A-I      intronic chr6:13193680(+) A-I      intronic chr6:13193744(+) A-I      intronic chr6:13193758(+) A-I      intronic chr6:13194477(+) A-I      intronic chr6:13194484(+) A-I      intronic chr6:13194485(+) A-I      intronic chr6:13193731(+) A-I      intronic chr6:13195893(+) A-I      intronic chr6:13199599(+) A-I      intronic chr6:13231155(+) A-I      intronic chr6:13231173(+) A-I      intronic chr6:13240796(+) A-I      intronic chr6:13240805(+) A-I      intronic chr6:13240931(+) A-I      intronic chr6:13254188(+) A-I      intronic chr6:13254304(+) A-I      intronic chr6:13254313(+) A-I      intronic chr6:13258443(+) A-I      intronic chr6:13271334(+) A-I      intronic chr6:13271366(+) A-I      intronic chr6:13271374(+) A-I      intronic chr6:13271380(+) A-I      intronic chr6:12832274(+) A-I      intronic chr6:12806030(+) A-I      intronic chr6:12806035(+) A-I      intronic chr6:12806043(+) A-I      intronic chr6:12830102(+) A-I      intronic chr6:12832289(+) A-I      intronic chr6:12832303(+) A-I      intronic chr6:12915561(+) A-I      intronic chr6:12915563(+) A-I      intronic chr6:12915577(+) A-I      intronic chr6:12915578(+) A-I      intronic chr6:12970867(+) A-I      intronic chr6:12970877(+) A-I      intronic chr6:12970881(+) A-I      intronic chr6:12970884(+) A-I      intronic chr6:12970908(+) A-I      intronic chr6:12970909(+) A-I      intronic chr6:13196714(+) A-I      intronic chr6:13196732(+) A-I      intronic chr6:13196733(+) A-I      intronic chr6:13196746(+) A-I      intronic chr6:13196752(+) A-I      intronic chr6:13196778(+) A-I      intronic chr6:13196779(+) A-I      intronic chr6:13196782(+) A-I      intronic chr6:13196794(+) A-I      intronic chr6:13196800(+) A-I      intronic chr6:12998034(+) A-I      intronic chr6:13019397(+) A-I      intronic chr6:12800986(+) A-I      intronic chr6:12788131(+) A-I      intronic chr6:12949408(+) A-I      intronic chr6:12830069(+) A-I      intronic chr6:12931154(+) A-I      intronic chr6:12758217(+) A-I      intronic chr6:13195915(+) A-I      intronic chr6:12821438(+) A-I      intronic chr6:13231017(+) A-I      intronic chr6:12830118(+) A-I      intronic chr6:12805974(+) A-I      intronic chr6:12912914(+) A-I      intronic chr6:13240845(+) A-I      intronic chr6:12975907(+) A-I      intronic chr6:12820675(+) A-I      intronic chr6:13193856(+) A-I      intronic chr6:12959288(+) A-I      intronic chr6:13247703(+) A-I      intronic chr6:13240779(+) A-I      intronic chr6:12833510(+) A-I      intronic chr6:13200474(+) A-I      intronic chr6:12914504(+) A-I      intronic chr6:13247963(+) A-I      intronic chr6:12873438(+) A-I      intronic chr6:12886171(+) A-I      intronic chr6:13248006(+) A-I      intronic chr6:13195910(+) A-I      intronic chr6:12901866(+) A-I      intronic chr6:13194488(+) A-I      intronic chr6:12915664(+) A-I      intronic chr6:13200668(+) A-I      intronic chr6:12857633(+) A-I      intronic chr6:12818329(+) A-I      intronic chr6:12884815(+) A-I      intronic chr6:13201062(+) A-I      intronic chr6:12821518(+) A-I      intronic chr6:12821507(+) A-I      intronic chr6:12945940(+) A-I      intronic chr6:13048893(+) A-I      intronic chr6:12830001(+) A-I      intronic chr6:12902570(+) A-I      intronic chr6:12857588(+) A-I      intronic chr6:13174124(+) A-I      intronic chr6:12955494(+) A-I      intronic chr6:12830047(+) A-I      intronic chr6:12830966(+) A-I      intronic chr6:12759197(+) A-I      intronic chr6:12831011(+) A-I      intronic chr6:12919634(+) A-I      intronic chr6:12947232(+) A-I      intronic chr6:12889346(+) A-I      intronic chr6:12886071(+) A-I      intronic chr6:13201087(+) A-I      intronic chr6:12970968(+) A-I      intronic chr6:13196722(+) A-I      intronic chr6:13240914(+) A-I      intronic chr6:12962300(+) A-I      intronic chr6:12830901(+) A-I      intronic chr6:12945276(+) A-I      intronic chr6:12886055(+) A-I      intronic chr6:12830022(+) A-I      intronic chr6:13105352(+) A-I      intronic chr6:12820513(+) A-I      intronic chr6:13199565(+) A-I      intronic chr6:12914429(+) A-I      intronic chr6:12830140(+) A-I      intronic chr6:12919572(+) A-I      intronic chr6:12873532(+) A-I      intronic chr6:13231168(+) A-I      intronic chr6:13201132(+) A-I      intronic chr6:12902643(+) A-I      intronic chr6:12895553(+) A-I      intronic chr6:12856762(+) A-I      intronic chr6:12938282(+) A-I      intronic chr6:12915505(+) A-I      intronic chr6:12955685(+) A-I      intronic chr6:12829931(+) A-I      intronic chr6:12829937(+) A-I      intronic chr6:12883668(+) A-I      intronic chr6:13199365(+) A-I      intronic chr6:12856692(+) A-I      intronic chr6:13200543(+) A-I      intronic chr6:12902397(+) A-I      intronic chr6:12919514(+) A-I      intronic chr6:12809265(+) A-I      intronic chr6:12894714(+) A-I      intronic chr6:12947305(+) A-I      intronic chr6:12947242(+) A-I      intronic chr6:13177461(+) A-I      intronic chr6:12933348(+) A-I      intronic chr6:13193894(+) A-I      intronic chr6:12830902(+) A-I      intronic chr6:12970975(+) A-I      intronic chr6:13249980(+) A-I      intronic chr6:12829986(+) A-I      intronic chr6:12830844(+) A-I      intronic chr6:13000618(+) A-I      intronic chr6:12832301(+) A-I      intronic chr6:13242077(+) A-I      intronic chr6:13252263(+) A-I      intronic chr6:13247717(+) A-I      intronic chr6:12894672(+) A-I      intronic chr6:12931176(+) A-I      intronic chr6:12883721(+) A-I      intronic chr6:12889340(+) A-I      intronic chr6:12852147(+) A-I      intronic chr6:13252085(+) A-I      intronic chr6:12758102(+) A-I      intronic chr6:13049025(+) A-I      intronic chr6:12915560(+) A-I      intronic chr6:12868237(+) A-I      intronic chr6:12949508(+) A-I      intronic chr6:12830922(+) A-I      intronic chr6:13195734(+) A-I      intronic chr6:12889345(+) A-I      intronic chr6:13231154(+) A-I      intronic chr6:13230684(+) A-I      intronic chr6:12930362(+) A-I      intronic chr6:12880723(+) A-I      intronic chr6:12931186(+) A-I      intronic chr6:12830043(+) A-I      intronic chr6:12832265(+) A-I      intronic chr6:12818262(+) A-I      intronic chr6:13252459(+) A-I      intronic chr6:13017210(+) A-I      intronic chr6:12830115(+) A-I      intronic chr6:12919647(+) A-I      intronic chr6:12858843(+) A-I      intronic chr6:13196916(+) A-I      intronic chr6:12832300(+) A-I      intronic chr6:13024186(+) A-I      intronic chr6:12917864(+) A-I      intronic chr6:12830038(+) A-I      intronic chr6:13048866(+) A-I      intronic chr6:12758422(+) A-I      intronic chr6:12831090(+) A-I      intronic chr6:12821561(+) A-I      intronic chr6:12889303(+) A-I      intronic chr6:12830041(+) A-I      intronic chr6:13247695(+) A-I      intronic chr6:13194381(+) A-I      intronic chr6:13199498(+) A-I      intronic chr6:13048867(+) A-I      intronic chr6:12949303(+) A-I      intronic chr6:13249860(+) A-I      intronic chr6:13144856(+) A-I      intronic chr6:12962247(+) A-I      intronic chr6:12785193(+) A-I      intronic chr6:12883482(+) A-I      intronic chr6:13195900(+) A-I      intronic chr6:13158398(+) A-I      intronic chr6:12894659(+) A-I      intronic chr6:13193810(+) A-I      intronic chr6:13254410(+) A-I      intronic chr6:13265093(+) A-I      intronic chr6:12914301(+) A-I      intronic chr6:12955697(+) A-I      intronic chr6:12758223(+) A-I      intronic chr6:13105373(+) A-I      intronic chr6:12852167(+) A-I      intronic chr6:12829985(+) A-I      intronic chr6:12832219(+) A-I      intronic chr6:12830042(+) A-I      intronic chr6:13118785(+) A-I      intronic chr6:12821616(+) A-I      intronic chr6:12829932(+) A-I      intronic chr6:12902549(+) A-I      intronic chr6:13195790(+) A-I      intronic chr6:12880675(+) A-I      intronic chr6:12779446(+) A-I      intronic chr6:12949342(+) A-I      intronic chr6:12830070(+) A-I      intronic chr6:13196678(+) A-I      intronic chr6:12902575(+) A-I      intronic chr6:12830057(+) A-I      intronic chr6:12857688(+) A-I      intronic chr6:13201082(+) A-I      intronic chr6:13249988(+) A-I      intronic chr6:12830982(+) A-I      intronic chr6:12805994(+) A-I      intronic chr6:12883580(+) A-I      intronic chr6:12844617(+) A-I      intronic chr6:12886072(+) A-I      intronic chr6:12930405(+) A-I      intronic chr6:13249829(+) A-I      intronic chr6:12821574(+) A-I      intronic chr6:13196676(+) A-I      intronic chr6:13218870(+) A-I      intronic chr6:12868369(+) A-I      intronic chr6:12830973(+) A-I      intronic chr6:12806055(+) A-I      intronic chr6:13196881(+) A-I      intronic chr6:12880676(+) A-I      intronic chr6:12746671(+) A-I      intronic chr6:13193896(+) A-I      intronic chr6:13142435(+) A-I      intronic chr6:12997937(+) A-I      intronic chr6:12915553(+) A-I      intronic chr6:13240899(+) A-I      intronic chr6:12949456(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PHACTR1	chr6:12934858(+) A-I intron -    15342557   //15258596 chr6:12934867(+) A-I intron -    15342557   //15258596 chr6:12934903(+) A-I intron -    15342557   //15258596 chr6:12934915(+) A-I intron -    15342557   //15258596 chr6:12934961(+) A-I intron -    15342557 chr6:12934997(+) A-I intron -    15342557 chr6:12935018(+) A-I intron -    15342557 chr6:12935031(+) A-I intron -    15342557 chr6:12935043(+) A-I intron -    15342557 chr6:12884815(+) A-G intron -    22484847 chr6:12884840(+) A-G intron -    22484847 chr6:13264769(+) T-C intron -    22484847 chr6:13264781(+) A-G intron -    22484847 chr6:13264858(+) G-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PHACTR1	chr6:12957727-12957728(+) m6A exon//intron       - chr6:12957759-12957760(+) m6A exon//intron       - chr6:12957904-12957905(+) m6A exon//intron       - chr6:12957947-12957948(+) m6A exon//intron       - chr6:12958217-12958218(+) m6A intron       - chr6:13272585-13272586(+) m6A exon//intron       27773535 chr6:13272617-13272618(+) m6A exon//intron       27773535 chr6:13272931-13272932(+) m6A 5'UTR//intron       - chr6:13272981-13272982(+) m6A 5'UTR//intron       - chr6:13272987-13272988(+) m6A 5'UTR//intron       - chr6:13273067-13273068(+) m6A CDS//intron       - chr6:13273121-13273122(+) m6A CDS//exon       - chr6:13273127-13273128(+) m6A CDS//exon       - chr6:13273135-13273136(+) m6A CDS//exon       - chr6:13287347-13287348(+) m6A 3'UTR       - chr6:13287363-13287364(+) m6A 3'UTR       - chr6:13287415-13287416(+) m6A 3'UTR       24981863 chr6:13287451-13287452(+) m6A 3'UTR       24981863 chr6:13287585-13287586(+) m6A 3'UTR       25456834 chr6:13287662-13287663(+) m6A 3'UTR       25456834 chr6:13287758-13287759(+) m6A 3'UTR       25456834 chr6:13287791-13287792(+) m6A 3'UTR       25456834 chr6:13287842-13287843(+) m6A 3'UTR       25456834 chr6:13287898-13287899(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-491-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	PHACTR1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-491-5p	Gemcitabine 60750 Drug interaction    RC00005366 Carboplatinum 38904 Drug interaction    RC00005365 Etoposide 36462 Drug interaction    RC00005364 Paclitaxel 36314 Drug interaction    RC00005363 5-Fluorouracil 3385 Drug interaction    RC00005360 Doxorubicin 31703 Drug interaction    RC00005362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359 Verapamil 2520 Drug interaction    RC00005358 Arsenic trioxide 14888 Drug interaction    RC00005361 Chemotherapy - Drug interaction    RC00008868

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-491-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-491-5p
Interactor2: PHACTR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.