Detail Information

Basic Information:


  VIRBase ID:  

HHID00058677

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:           NACC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-491-5p NACC2
miRBase
Accession/Entrez ID		 MIMAT0002807 138151
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BEND9//BTBD14//BTBD14A//BTBD31//NAC-2//RBB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-491-5p
rs1302649663 chr9:20716133    TC/T
rs1443323273 chr9:20716132    T/G
rs563573084 chr9:20716129    C/T
rs760801072 chr9:20716135    C/T
rs768108997 chr9:20716130    C/T
rs773685607 chr9:20716134    C/G
rs773685607 chr9:20716134    C/T
rs774721604 chr9:20716128    A/T
rs1441505194 chr9:20716126    G/A
rs768906975 chr9:20716122    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NACC2
chr9:138977092(-) A-I      intronic
chr9:138969891(-) A-I      intronic
chr9:138968636(-) A-I      intronic
chr9:138968625(-) A-I      intronic
chr9:138968620(-) A-I      intronic
chr9:138968610(-) A-I      intronic
chr9:138920283(-) A-I      intronic
chr9:138960949(-) A-I      intronic
chr9:138923256(-) A-I      intronic
chr9:138923280(-) A-I      intronic
chr9:138923281(-) A-I      intronic
chr9:138961381(-) A-I      intronic
chr9:138960948(-) A-I      intronic
chr9:138917993(-) A-I      intronic
chr9:138960891(-) A-I      intronic
chr9:138924699(-) A-I      intronic
chr9:138924665(-) A-I      intronic
chr9:138924595(-) A-I      intronic
chr9:138960947(-) A-I      intronic
chr9:138923289(-) A-I      intronic
chr9:138923298(-) A-I      intronic
chr9:138960890(-) A-I      intronic
chr9:138960917(-) A-I      intronic
chr9:138961033(-) A-I      intronic
chr9:138924586(-) A-I      intronic
chr9:138961038(-) A-I      intronic
chr9:138961273(-) A-I      intronic
chr9:138924580(-) A-I      intronic
chr9:138961361(-) A-I      intronic
chr9:138960927(-) A-I      intronic
chr9:138961369(-) A-I      intronic
chr9:138960929(-) A-I      intronic
chr9:138917975(-) A-I      intronic
chr9:138960930(-) A-I      intronic
chr9:138924560(-) A-I      intronic
chr9:138960933(-) A-I      intronic
chr9:138960936(-) A-I      intronic
chr9:138960920(-) A-I      intronic
chr9:138923322(-) A-I      intronic
chr9:138929365(-) A-I      intronic
chr9:138919959(-) A-I      intronic
chr9:138922291(-) A-I      intronic
chr9:138919944(-) A-I      intronic
chr9:138922682(-) A-I      intronic
chr9:138977111(-) A-I      intronic
chr9:138920314(-) A-I      intronic
chr9:138929363(-) A-I      intronic
chr9:138920329(-) A-I      intronic
chr9:138922199(-) A-I      intronic
chr9:138961167(-) A-I      intronic
chr9:138957365(-) A-I      intronic
chr9:138920227(-) A-I      intronic
chr9:138959654(-) A-I      intronic
chr9:138929362(-) A-I      intronic
chr9:138929364(-) A-I      intronic
chr9:138961203(-) A-I      intronic
chr9:138961158(-) A-I      intronic
chr9:138921976(-) A-I      intronic
chr9:138977133(-) A-I      intronic
chr9:138922211(-) A-I      intronic
chr9:138922798(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NACC2
chr9:138898827-138898828(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:138898928-138898929(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:138898940-138898941(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:138898963-138898964(-) m6A 3'UTR       24981863
chr9:138899564-138899565(-) m6A 3'UTR       24284625//24981863
chr9:138899573-138899574(-) m6A 3'UTR       24284625//24981863
chr9:138899584-138899585(-) m6A 3'UTR       24284625//24981863
chr9:138899624-138899625(-) m6A 3'UTR       24284625//24981863//22608085
chr9:138899706-138899707(-) m6A 3'UTR       24284625//24981863
chr9:138899870-138899871(-) m6A 3'UTR       25456834//24981863//26404942
chr9:138899919-138899920(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr9:138899947-138899948(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr9:138900112-138900113(-) m6A 3'UTR       24284625//25456834
chr9:138900240-138900241(-) m6A 3'UTR       24284625//24981863//26404942
chr9:138900245-138900246(-) m6A 3'UTR       24284625//24981863//26404942
chr9:138900254-138900255(-) m6A 3'UTR       24284625//24981863//26404942
chr9:138900493-138900494(-) m6A 3'UTR       24284625
chr9:138900608-138900609(-) m6A 3'UTR       24284625
chr9:138900775-138900776(-) Am 3'UTR       -
chr9:138901286-138901287(-) m6A 3'UTR       24284625
chr9:138901292-138901293(-) m6A 3'UTR       24284625
chr9:138901362-138901363(-) m6A 3'UTR       24284625
chr9:138901453-138901454(-) m6A 3'UTR       24284625
chr9:138901478-138901479(-) m6A 3'UTR       24284625
chr9:138901562-138901563(-) m6A 3'UTR       24284625
chr9:138901588-138901589(-) m6A 3'UTR       24284625
chr9:138901720-138901721(-) m6A 3'UTR       24284625
chr9:138901748-138901749(-) m6A 3'UTR       24284625
chr9:138901785-138901786(-) m6A 3'UTR       24284625
chr9:138902022-138902023(-) m6A 3'UTR       24284625//24981863
chr9:138902056-138902057(-) m6A 3'UTR       24284625//24981863
chr9:138902101-138902102(-) m6A 3'UTR       24284625//24981863//27371828
chr9:138902238-138902239(-) m6A 3'UTR       24284625//24981863//22575960
chr9:138902254-138902255(-) m6A 3'UTR       24284625//22575960
chr9:138902331-138902332(-) m6A 3'UTR       24284625
chr9:138903177-138903178(-) m6A 3'UTR       24284625//24981863
chr9:138903201-138903202(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr9:138903266-138903267(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:138903296-138903297(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:138903335-138903336(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:138903369-138903370(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr9:138903594-138903595(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr9:138903809-138903810(-) m6A CDS       24284625//24209618//24981863//22575960
chr9:138903857-138903858(-) m6A CDS       24284625
chr9:138905070-138905071(-) m6A CDS       24284625
chr9:138905116-138905117(-) m6A CDS       24284625
chr9:138905139-138905140(-) m6A CDS       24284625
chr9:138905778-138905779(-) m6A CDS       24284625
chr9:138908139-138908140(-) m6A CDS//exon       24284625//27371828
chr9:138908182-138908183(-) Cm CDS//exon       -
chr9:138911038-138911039(-) m6A exon//intron       24284625//27371828//27773536
chr9:138911084-138911085(-) m6A exon//intron       24284625
chr9:138987053-138987054(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-491-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
NACC2
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-491-5p
Gemcitabine 60750 Drug interaction    RC00005366
Carboplatinum 38904 Drug interaction    RC00005365
Etoposide 36462 Drug interaction    RC00005364
Paclitaxel 36314 Drug interaction    RC00005363
5-Fluorouracil 3385 Drug interaction    RC00005360
Doxorubicin 31703 Drug interaction    RC00005362
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359
Verapamil 2520 Drug interaction    RC00005358
Arsenic trioxide 14888 Drug interaction    RC00005361
Chemotherapy - Drug interaction    RC00008868
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-491-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-491-5p
Interactor2: NACC2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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