Basic Information:

  VIRBase ID:  

HHID00058674

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:  MIMAT0002807          MARCHF9:  NM_138396     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-491-5p	MARCHF9
miRBase Accession/Entrez ID	MIMAT0002807	92979
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MARCH-IX//MARCH9//RNF179

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-491-5p	rs1302649663 chr9:20716133    TC/T rs1443323273 chr9:20716132    T/G rs563573084 chr9:20716129    C/T rs760801072 chr9:20716135    C/T rs768108997 chr9:20716130    C/T rs773685607 chr9:20716134    C/G rs773685607 chr9:20716134    C/T rs774721604 chr9:20716128    A/T rs1441505194 chr9:20716126    G/A rs768906975 chr9:20716122    T/C

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-491-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	MARCHF9	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-491-5p	Gemcitabine 60750 Drug interaction    RC00005366 Carboplatinum 38904 Drug interaction    RC00005365 Etoposide 36462 Drug interaction    RC00005364 Paclitaxel 36314 Drug interaction    RC00005363 5-Fluorouracil 3385 Drug interaction    RC00005360 Doxorubicin 31703 Drug interaction    RC00005362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359 Verapamil 2520 Drug interaction    RC00005358 Arsenic trioxide 14888 Drug interaction    RC00005361 Chemotherapy - Drug interaction    RC00008868

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-491-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-491-5p
Interactor2: MARCHF9

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.