Basic Information:

  VIRBase ID:  

HHID00058672

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:  MIMAT0002807          MIDN:  NM_177401     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-491-5p	MIDN
miRBase Accession/Entrez ID	MIMAT0002807	90007
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Stx

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-491-5p	rs1302649663 chr9:20716133    TC/T rs1443323273 chr9:20716132    T/G rs563573084 chr9:20716129    C/T rs760801072 chr9:20716135    C/T rs768108997 chr9:20716130    C/T rs773685607 chr9:20716134    C/G rs773685607 chr9:20716134    C/T rs774721604 chr9:20716128    A/T rs1441505194 chr9:20716126    G/A rs768906975 chr9:20716122    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIDN	chr19:1256335(+) A-I      intronic chr19:1256649(+) A-I      intronic chr19:1256686(+) A-I      intronic chr19:1256695(+) A-I      intronic chr19:1256642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIDN	chr19:1248583-1248584(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1248645-1248646(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1250001-1250002(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828 chr19:1250152-1250153(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:1250202-1250203(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:1250524-1250525(+) m6A CDS       - chr19:1254322-1254323(+) m6A CDS       24284625 chr19:1254907-1254908(+) m6A CDS       24284625//24981863 chr19:1254995-1254996(+) m6A CDS       24284625 chr19:1255050-1255051(+) m6A CDS       24284625 chr19:1255444-1255445(+) m6A CDS       24284625 chr19:1255608-1255609(+) m6A CDS       24284625 chr19:1256996-1256997(+) m6A CDS       24284625//22575960 chr19:1257010-1257011(+) m6A CDS       24284625//22575960 chr19:1257017-1257018(+) m6A CDS       24284625 chr19:1257212-1257213(+) m6A CDS       24284625//24209618//24981863//22575960 chr19:1257324-1257325(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr19:1257461-1257462(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr19:1257763-1257764(+) m6A 3'UTR       26404942 chr19:1257786-1257787(+) m6A 3'UTR       26404942 chr19:1258032-1258033(+) m6A 3'UTR       24284625 chr19:1258074-1258075(+) m6A 3'UTR       24284625//24981863 chr19:1258143-1258144(+) m6A 3'UTR       24284625//24981863//26404942 chr19:1258181-1258182(+) m6A 3'UTR       25456834//24981863//26404942//27773535 chr19:1258274-1258275(+) m6A 3'UTR       24284625//25456834 chr19:1258854-1258855(+) m6A 3'UTR       27773535 chr19:1259068-1259069(+) m6A 3'UTR       27773535 chr19:1259093-1259094(+) m6A 3'UTR       27773535 chr19:1259125-1259126(+) m6A 3'UTR       27773535 chr19:1259137-1259138(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-491-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	MIDN	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-491-5p	Gemcitabine 60750 Drug interaction    RC00005366 Carboplatinum 38904 Drug interaction    RC00005365 Etoposide 36462 Drug interaction    RC00005364 Paclitaxel 36314 Drug interaction    RC00005363 5-Fluorouracil 3385 Drug interaction    RC00005360 Doxorubicin 31703 Drug interaction    RC00005362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359 Verapamil 2520 Drug interaction    RC00005358 Arsenic trioxide 14888 Drug interaction    RC00005361 Chemotherapy - Drug interaction    RC00008868

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-491-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-491-5p
Interactor2: MIDN

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.