Detail Information

Basic Information:


  VIRBase ID:  

HHID00058671

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:           NFKBID:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-491-5p NFKBID
miRBase
Accession/Entrez ID		 MIMAT0002807 84807
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IkappaBNS//IkBNS//TA-NFKBH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-491-5p
rs1302649663 chr9:20716133    TC/T
rs1443323273 chr9:20716132    T/G
rs563573084 chr9:20716129    C/T
rs760801072 chr9:20716135    C/T
rs768108997 chr9:20716130    C/T
rs773685607 chr9:20716134    C/G
rs773685607 chr9:20716134    C/T
rs774721604 chr9:20716128    A/T
rs1441505194 chr9:20716126    G/A
rs768906975 chr9:20716122    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NFKBID
chr19:36385123(-) A-I      intronic
chr19:36388268(-) A-I      intronic
chr19:36383082(-) A-I      intronic
chr19:36385492(-) A-I      intronic
chr19:36383021(-) A-I      intronic
chr19:36383069(-) A-I      intronic
chr19:36383172(-) A-I      intronic
chr19:36383947(-) A-I      intronic
chr19:36383962(-) A-I      intronic
chr19:36384021(-) A-I      intronic
chr19:36382822(-) A-I      intronic
chr19:36382964(-) A-I      intronic
chr19:36382882(-) A-I      intronic
chr19:36382887(-) A-I      intronic
chr19:36383125(-) A-I      intronic
chr19:36388294(-) A-I      intronic
chr19:36383121(-) A-I      intronic
chr19:36383086(-) A-I      intronic
chr19:36383989(-) A-I      intronic
chr19:36383181(-) A-I      intronic
chr19:36382863(-) A-I      intronic
chr19:36384553(-) A-I      intronic
chr19:36382730(-) A-I      intronic
chr19:36388224(-) A-I      intronic
chr19:36382755(-) A-I      intronic
chr19:36383369(-) A-I      intronic
chr19:36383051(-) A-I      intronic
chr19:36388324(-) A-I      intronic
chr19:36382901(-) A-I      intronic
chr19:36382682(-) A-I      intronic
chr19:36383875(-) A-I      intronic
chr19:36382660(-) A-I      intronic
chr19:36383000(-) A-I      intronic
chr19:36383824(-) A-I      intronic
chr19:36383153(-) A-I      intronic
chr19:36383210(-) A-I      intronic
chr19:36383963(-) A-I      intronic
chr19:36382554(-) A-I      intronic
chr19:36385387(-) A-I      intronic
chr19:36383142(-) A-I      intronic
chr19:36389237(-) A-I      intronic
chr19:36382669(-) A-I      intronic
chr19:36383135(-) A-I      intronic
chr19:36382657(-) A-I      intronic
chr19:36383133(-) A-I      intronic
chr19:36382706(-) A-I      intronic
chr19:36385392(-) A-I      intronic
chr19:36382687(-) A-I      intronic
chr19:36383123(-) A-I      intronic
chr19:36388186(-) A-I      intronic
chr19:36391824(-) A-I      intronic
chr19:36388187(-) A-I      intronic
chr19:36392650(-) A-I      intronic
chr19:36383177(-) A-I      intronic
chr19:36383131(-) A-I      intronic
chr19:36383949(-) A-I      intronic
chr19:36383158(-) A-I      intronic
chr19:36388295(-) A-I      intronic
chr19:36388192(-) A-I      intronic
chr19:36382686(-) A-I      intronic
chr19:36383050(-) A-I      intronic
chr19:36382526(-) A-I      intronic
chr19:36384071(-) A-I      intronic
chr19:36389167(-) A-I      intronic
chr19:36391882(-) A-I      intronic
chr19:36382988(-) A-I      intronic
chr19:36382982(-) A-I      intronic
chr19:36383102(-) A-I      intronic
chr19:36382923(-) A-I      intronic
chr19:36385562(-) A-I      intronic
chr19:36384069(-) A-I      intronic
chr19:36382847(-) A-I      intronic
chr19:36389142(-) A-I      intronic
chr19:36383157(-) A-I      intronic
chr19:36385651(-) A-I      intronic
chr19:36382900(-) A-I      intronic
chr19:36383340(-) A-I      intronic
chr19:36382922(-) A-I      intronic
chr19:36383849(-) A-I      intronic
chr19:36383352(-) A-I      intronic
chr19:36381728(-) A-I      intronic
chr19:36383007(-) A-I      intronic
chr19:36383221(-) A-I      intronic
chr19:36383124(-) A-I      intronic
chr19:36383370(-) A-I      intronic
chr19:36379673(-) A-I      intronic
chr19:36383227(-) A-I      intronic
chr19:36384065(-) A-I      intronic
chr19:36383226(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NFKBID
chr19:36382661(-) A-I intron -    22327324
chr19:36383007(-) A-I intron -    22327324
chr19:36383051(-) A-I intron -    22327324
chr19:36383078(-) A-I intron -    22327324
chr19:36383118(-) A-I intron -    22327324
chr19:36383177(-) A-I intron -    22327324
chr19:36383226(-) A-I intron -    22327324
chr19:36383963(-) A-I intron -    22327324
chr19:36381600(-) A-G intron -    22484847
chr19:36382554(-) A-G intron -    22484847
chr19:36382661(-) A-G intron -    22484847
chr19:36382669(-) A-G intron -    22484847
chr19:36382706(-) A-G intron -    22484847
chr19:36382707(-) A-G intron -    22484847
chr19:36382730(-) A-G intron -    22484847
chr19:36382755(-) A-G intron -    22484847
chr19:36382901(-) A-G intron -    22484847
chr19:36382922(-) A-G intron -    22484847
chr19:36382988(-) A-G intron -    22484847
chr19:36383007(-) A-G intron -    22484847
chr19:36383050(-) A-G intron -    22484847
chr19:36383051(-) A-G intron -    22484847
chr19:36383078(-) A-G intron -    22484847
chr19:36383086(-) A-G intron -    22484847
chr19:36383118(-) A-G intron -    22484847
chr19:36383121(-) A-G intron -    22484847
chr19:36383123(-) A-G intron -    22484847
chr19:36383124(-) A-G intron -    22484847
chr19:36383125(-) A-G intron -    22484847
chr19:36383127(-) A-G intron -    22484847
chr19:36383153(-) A-G intron -    22484847
chr19:36383177(-) A-G intron -    22484847
chr19:36383181(-) A-G intron -    22484847
chr19:36383221(-) A-G intron -    22484847
chr19:36383226(-) A-G intron -    22484847
chr19:36383227(-) A-G intron -    22484847
chr19:36383824(-) A-G intron -    22484847
chr19:36383959(-) A-G intron -    22484847
chr19:36383963(-) A-G intron -    22484847
chr19:36383989(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NFKBID
chr19:36378869-36378870(-) m6A 3'UTR       27773535
chr19:36378928-36378929(-) m6A 3'UTR       27773535
chr19:36378983-36378984(-) m6A 3'UTR       27773535
chr19:36379000-36379001(-) m6A 3'UTR       27773535
chr19:36379009-36379010(-) m6A 3'UTR       27773535
chr19:36379038-36379039(-) m6A 3'UTR       27773535
chr19:36379127-36379128(-) m6A 3'UTR       27773535
chr19:36379204-36379205(-) m6A 3'UTR       27773535
chr19:36379306-36379307(-) m6A 3'UTR       26404942
chr19:36379332-36379333(-) m6A 3'UTR       26404942
chr19:36379382-36379383(-) m6A 3'UTR       26404942
chr19:36379408-36379409(-) m6A 3'UTR       26404942
chr19:36379439-36379440(-) m6A 3'UTR       26404942
chr19:36379446-36379447(-) m6A 3'UTR       26404942
chr19:36379452-36379453(-) m6A 3'UTR       26404942
chr19:36379458-36379459(-) m6A 3'UTR       26404942
chr19:36387994-36387995(-) m6A CDS//intron       -
chr19:36388728-36388729(-) m6A 5'UTR//exon//intron       27371828
chr19:36389431-36389432(-) m6A 5'UTR//exon       27371828//27773536
chr19:36389688-36389689(-) m6A 5'UTR//exon       27371828//27773536
chr19:36390623-36390624(-) m6A exon//intron       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-491-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
NFKBID
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-491-5p
Gemcitabine 60750 Drug interaction    RC00005366
Carboplatinum 38904 Drug interaction    RC00005365
Etoposide 36462 Drug interaction    RC00005364
Paclitaxel 36314 Drug interaction    RC00005363
5-Fluorouracil 3385 Drug interaction    RC00005360
Doxorubicin 31703 Drug interaction    RC00005362
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359
Verapamil 2520 Drug interaction    RC00005358
Arsenic trioxide 14888 Drug interaction    RC00005361
Chemotherapy - Drug interaction    RC00008868
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-491-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-491-5p
Interactor2: NFKBID

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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