Detail Information

Basic Information:


  VIRBase ID:  

HHID00058663

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:           GEMIN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-491-5p GEMIN4
miRBase
Accession/Entrez ID		 MIMAT0002807 50628
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HC56//HCAP1//HHRF-1//NEDMCR//p97

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-491-5p
rs1302649663 chr9:20716133    TC/T
rs1443323273 chr9:20716132    T/G
rs563573084 chr9:20716129    C/T
rs760801072 chr9:20716135    C/T
rs768108997 chr9:20716130    C/T
rs773685607 chr9:20716134    C/G
rs773685607 chr9:20716134    C/T
rs774721604 chr9:20716128    A/T
rs1441505194 chr9:20716126    G/A
rs768906975 chr9:20716122    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GEMIN4
chr17:653433(-) A-I      intronic
chr17:653361(-) A-I      intronic
chr17:653407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GEMIN4
chr17:653361(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GEMIN4
chr17:647702-647703(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647744-647745(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647760-647761(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647889-647890(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr17:647958-647959(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647976-647977(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647991-647992(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:648134-648135(-) m6A CDS       24284625//24209618//24981863//26404942//27371828//27773536//22575960//22608085
chr17:648230-648231(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648242-648243(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648260-648261(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648373-648374(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr17:648384-648385(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr17:648427-648428(-) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr17:648459-648460(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648472-648473(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648530-648531(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:648648-648649(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr17:648741-648742(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr17:648878-648879(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:648977-648978(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648982-648983(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648990-648991(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649046-649047(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649165-649166(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649211-649212(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649253-649254(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649279-649280(-) m6A CDS       24284625//24981863//22608085
chr17:649374-649375(-) m6A CDS       24284625//22608085
chr17:649396-649397(-) m6A CDS       24284625
chr17:649665-649666(-) m6A CDS       24284625//22575960
chr17:649708-649709(-) m6A CDS       24284625//22575960
chr17:649816-649817(-) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085
chr17:649904-649905(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649927-649928(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649994-649995(-) m1A 3'UTR//CDS       26863410//26863196
chr17:650035-650036(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650095-650096(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650128-650129(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650167-650168(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650191-650192(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650261-650262(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650348-650349(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650361-650362(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650446-650447(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650452-650453(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650482-650483(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650665-650666(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650755-650756(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650844-650845(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650862-650863(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650913-650914(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650998-650999(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651014-651015(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651262-651263(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651270-651271(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651313-651314(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085
chr17:651350-651351(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr17:651366-651367(-) m6A 5'UTR//intron       24284625//24981863
chr17:651791-651792(-) m6A 5'UTR//intron       24284625
chr17:655265-655266(-) m6A 5'UTR//intron       24284625//24981863
chr17:655377-655378(-) m6A 5'UTR//CDS//intron       24284625//24981863
chr17:655859-655860(-) m6A 5'UTR//intron       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-491-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
GEMIN4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-491-5p
Gemcitabine 60750 Drug interaction    RC00005366
Carboplatinum 38904 Drug interaction    RC00005365
Etoposide 36462 Drug interaction    RC00005364
Paclitaxel 36314 Drug interaction    RC00005363
5-Fluorouracil 3385 Drug interaction    RC00005360
Doxorubicin 31703 Drug interaction    RC00005362
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359
Verapamil 2520 Drug interaction    RC00005358
Arsenic trioxide 14888 Drug interaction    RC00005361
Chemotherapy - Drug interaction    RC00008868
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-491-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-491-5p
Interactor2: GEMIN4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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