Basic Information:

  VIRBase ID:  

HHID00058658

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:  MIMAT0002807          DCAF12:  NM_015397     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-491-5p	DCAF12
miRBase Accession/Entrez ID	MIMAT0002807	25853
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CT102//KIAA1892//TCC52//WDR40A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-491-5p	rs1302649663 chr9:20716133    TC/T rs1443323273 chr9:20716132    T/G rs563573084 chr9:20716129    C/T rs760801072 chr9:20716135    C/T rs768108997 chr9:20716130    C/T rs773685607 chr9:20716134    C/G rs773685607 chr9:20716134    C/T rs774721604 chr9:20716128    A/T rs1441505194 chr9:20716126    G/A rs768906975 chr9:20716122    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCAF12	chr9:34105914(-) A-I      intronic chr9:34101962(-) A-I      intronic chr9:34105871(-) A-I      intronic chr9:34105866(-) A-I      intronic chr9:34096308(-) A-I      intronic chr9:34097751(-) A-I      intronic chr9:34113292(-) A-I      intronic chr9:34098801(-) A-I      intronic chr9:34113277(-) A-I      intronic chr9:34113249(-) A-I      intronic chr9:34101622(-) A-I      intronic chr9:34101608(-) A-I      intronic chr9:34101609(-) A-I      intronic chr9:34113134(-) A-I      intronic chr9:34112857(-) A-I      intronic chr9:34112844(-) A-I      intronic chr9:34112731(-) A-I      intronic chr9:34111185(-) A-I      intronic chr9:34111095(-) A-I      intronic chr9:34105952(-) A-I      intronic chr9:34105942(-) A-I      intronic chr9:34095481(-) A-I      intronic chr9:34094801(-) A-I      intronic chr9:34094800(-) A-I      intronic chr9:34094733(-) A-I      intronic chr9:34094709(-) A-I      intronic chr9:34101617(-) A-I      intronic chr9:34094708(-) A-I      intronic chr9:34096255(-) A-I      intronic chr9:34100157(-) A-I      intronic chr9:34101132(-) A-I      intronic chr9:34096237(-) A-I      intronic chr9:34096174(-) A-I      intronic chr9:34091534(-) A-I      intronic chr9:34096149(-) A-I      intronic chr9:34101145(-) A-I      intronic chr9:34096171(-) A-I      intronic chr9:34101493(-) A-I      intronic chr9:34101528(-) A-I      intronic chr9:34095471(-) A-I      intronic chr9:34094260(-) A-I      intronic chr9:34094269(-) A-I      intronic chr9:34101563(-) A-I      intronic chr9:34094292(-) A-I      intronic chr9:34094328(-) A-I      intronic chr9:34101583(-) A-I      intronic chr9:34094360(-) A-I      intronic chr9:34094370(-) A-I      intronic chr9:34094373(-) A-I      intronic chr9:34094390(-) A-I      intronic chr9:34094621(-) A-I      intronic chr9:34094649(-) A-I      intronic chr9:34094667(-) A-I      intronic chr9:34094693(-) A-I      intronic chr9:34101589(-) A-I      intronic chr9:34101591(-) A-I      intronic chr9:34122586(-) A-I      intronic chr9:34121116(-) A-I      intronic chr9:34121030(-) A-I      intronic chr9:34101181(-) A-I      intronic chr9:34120239(-) A-I      intronic chr9:34120101(-) A-I      intronic chr9:34119955(-) A-I      intronic chr9:34118957(-) A-I      intronic chr9:34094256(-) A-I      intronic chr9:34118853(-) A-I      intronic chr9:34118805(-) A-I      intronic chr9:34118799(-) A-I      intronic chr9:34118732(-) A-I      intronic chr9:34118378(-) A-I      intronic chr9:34118314(-) A-I      intronic chr9:34118243(-) A-I      intronic chr9:34092602(-) A-I      intronic chr9:34117830(-) A-I      intronic chr9:34117702(-) A-I      intronic chr9:34116596(-) A-I      intronic chr9:34116545(-) A-I      intronic chr9:34091432(-) A-I      intronic chr9:34105151(-) A-I      intronic chr9:34105342(-) A-I      intronic chr9:34122767(-) A-I      intronic chr9:34122613(-) A-I      intronic chr9:34091539(-) A-I      intronic chr9:34122603(-) A-I      intronic chr9:34122607(-) A-I      intronic chr9:34091548(-) A-I      intronic chr9:34097458(-) A-I      intronic chr9:34092891(-) A-I      intronic chr9:34092981(-) A-I      intronic chr9:34093016(-) A-I      intronic chr9:34093018(-) A-I      intronic chr9:34090151(-) A-I      intronic chr9:34090173(-) A-I      intronic chr9:34090178(-) A-I      intronic chr9:34093022(-) A-I      intronic chr9:34090237(-) A-I      intronic chr9:34090263(-) A-I      intronic chr9:34090280(-) A-I      intronic chr9:34090281(-) A-I      intronic chr9:34090333(-) A-I      intronic chr9:34090347(-) A-I      intronic chr9:34090720(-) A-I      intronic chr9:34090721(-) A-I      intronic chr9:34090920(-) A-I      intronic chr9:34090928(-) A-I      intronic chr9:34090937(-) A-I      intronic chr9:34091107(-) A-I      intronic chr9:34091131(-) A-I      intronic chr9:34091145(-) A-I      intronic chr9:34091213(-) A-I      intronic chr9:34093036(-) A-I      intronic chr9:34094168(-) A-I      intronic chr9:34094223(-) A-I      intronic chr9:34101662(-) A-I      intronic chr9:34105919(-) A-I      intronic chr9:34101646(-) A-I      intronic chr9:34116811(-) A-I      intronic chr9:34113619(-) A-I      intronic chr9:34094237(-) A-I      intronic chr9:34105918(-) A-I      intronic chr9:34113542(-) A-I      intronic chr9:34113541(-) A-I      intronic chr9:34090210(-) A-I      intronic chr9:34095604(-) A-I      intronic chr9:34102565(-) A-I      intronic chr9:34122612(-) A-I      intronic chr9:34113517(-) A-I      intronic chr9:34113356(-) A-I      intronic chr9:34113299(-) A-I      intronic chr9:34105191(-) A-I      intronic chr9:34102568(-) A-I      intronic chr9:34103790(-) A-I      intronic chr9:34105630(-) A-I      intronic chr9:34102476(-) A-I      intronic chr9:34103833(-) A-I      intronic chr9:34105858(-) A-I      intronic chr9:34105188(-) A-I      intronic chr9:34105127(-) A-I      intronic chr9:34095619(-) A-I      intronic chr9:34104087(-) A-I      intronic chr9:34105606(-) A-I      intronic chr9:34104639(-) A-I      intronic chr9:34104748(-) A-I      intronic chr9:34104751(-) A-I      intronic chr9:34104830(-) A-I      intronic chr9:34095653(-) A-I      intronic chr9:34095633(-) A-I      intronic chr9:34102487(-) A-I      intronic chr9:34095611(-) A-I      intronic chr9:34101970(-) A-I      intronic chr9:34094246(-) A-I      intronic chr9:34116796(-) A-I      intronic chr9:34100131(-) A-I      intronic chr9:34101502(-) A-I      intronic chr9:34121938(-) A-I      intronic chr9:34112780(-) A-I      intronic chr9:34119870(-) A-I      intronic chr9:34119960(-) A-I      intronic chr9:34101968(-) A-I      intronic chr9:34113611(-) A-I      intronic chr9:34121033(-) A-I      intronic chr9:34102569(-) A-I      intronic chr9:34105911(-) A-I      intronic chr9:34122547(-) A-I      intronic chr9:34120605(-) A-I      intronic chr9:34121934(-) A-I      intronic chr9:34116729(-) A-I      intronic chr9:34102964(-) A-I      intronic chr9:34105175(-) A-I      intronic chr9:34116200(-) A-I      intronic chr9:34097887(-) A-I      intronic chr9:34118850(-) A-I      intronic chr9:34101809(-) A-I      intronic chr9:34118854(-) A-I      intronic chr9:34102496(-) A-I      intronic chr9:34101168(-) A-I      intronic chr9:34104179(-) A-I      intronic chr9:34103038(-) A-I      intronic chr9:34100122(-) A-I      intronic chr9:34108607(-) A-I      intronic chr9:34106242(-) A-I      intronic chr9:34104252(-) A-I      intronic chr9:34097819(-) A-I      intronic chr9:34101329(-) A-I      intronic chr9:34098964(-) A-I      intronic chr9:34117415(-) A-I      intronic chr9:34119875(-) A-I      intronic chr9:34117826(-) A-I      intronic chr9:34096431(-) A-I      intronic chr9:34118770(-) A-I      intronic chr9:34116816(-) A-I      intronic chr9:34104793(-) A-I      intronic chr9:34104651(-) A-I      intronic chr9:34122766(-) A-I      intronic chr9:34104187(-) A-I      intronic chr9:34120119(-) A-I      intronic chr9:34119797(-) A-I      intronic chr9:34101275(-) A-I      intronic chr9:34105885(-) A-I      intronic chr9:34100644(-) A-I      intronic chr9:34105814(-) A-I      intronic chr9:34112346(-) A-I      intronic chr9:34101866(-) A-I      intronic chr9:34101208(-) A-I      intronic chr9:34094757(-) A-I      intronic chr9:34104064(-) A-I      intronic chr9:34106199(-) A-I      intronic chr9:34105855(-) A-I      intronic chr9:34101148(-) A-I      intronic chr9:34118880(-) A-I      intronic chr9:34105294(-) A-I      intronic chr9:34100869(-) A-I      intronic chr9:34103783(-) A-I      intronic chr9:34096362(-) A-I      intronic chr9:34116164(-) A-I      intronic chr9:34111162(-) A-I      intronic chr9:34097879(-) A-I      intronic chr9:34102074(-) A-I      intronic chr9:34105210(-) A-I      intronic chr9:34119864(-) A-I      intronic chr9:34104657(-) A-I      intronic chr9:34116813(-) A-I      intronic chr9:34119972(-) A-I      intronic chr9:34119882(-) A-I      intronic chr9:34105315(-) A-I      intronic chr9:34117829(-) A-I      intronic chr9:34112337(-) A-I      intronic chr9:34097674(-) A-I      intronic chr9:34114865(-) A-I      intronic chr9:34119888(-) A-I      intronic chr9:34101796(-) A-I      intronic chr9:34122639(-) A-I      intronic chr9:34122628(-) A-I      intronic chr9:34105755(-) A-I      intronic chr9:34119899(-) A-I      intronic chr9:34113502(-) A-I      intronic chr9:34104668(-) A-I      intronic chr9:34101162(-) A-I      intronic chr9:34106202(-) A-I      intronic chr9:34101512(-) A-I      intronic chr9:34100631(-) A-I      intronic chr9:34122726(-) A-I      intronic chr9:34118814(-) A-I      intronic chr9:34101271(-) A-I      intronic chr9:34101135(-) A-I      intronic chr9:34113475(-) A-I      intronic chr9:34118288(-) A-I      intronic chr9:34105926(-) A-I      intronic chr9:34097353(-) A-I      intronic chr9:34121819(-) A-I      intronic chr9:34101529(-) A-I      intronic chr9:34121686(-) A-I      intronic chr9:34105544(-) A-I      intronic chr9:34111166(-) A-I      intronic chr9:34101153(-) A-I      intronic chr9:34119828(-) A-I      intronic chr9:34097496(-) A-I      intronic chr9:34105341(-) A-I      intronic chr9:34119788(-) A-I      intronic chr9:34091584(-) A-I      intronic chr9:34097483(-) A-I      intronic chr9:34099730(-) A-I      intronic chr9:34119814(-) A-I      intronic chr9:34118887(-) A-I      intronic chr9:34121069(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCAF12	chr9:34097887(-) A-G intron -    22484847 chr9:34119882(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCAF12	chr9:34086689-34086690(-) m6A 3'UTR       26404942 chr9:34088369-34088370(-) m6A CDS       24981863 chr9:34088413-34088414(-) m6A CDS       24981863 chr9:34088471-34088472(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-491-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	DCAF12	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-491-5p	Gemcitabine 60750 Drug interaction    RC00005366 Carboplatinum 38904 Drug interaction    RC00005365 Etoposide 36462 Drug interaction    RC00005364 Paclitaxel 36314 Drug interaction    RC00005363 5-Fluorouracil 3385 Drug interaction    RC00005360 Doxorubicin 31703 Drug interaction    RC00005362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359 Verapamil 2520 Drug interaction    RC00005358 Arsenic trioxide 14888 Drug interaction    RC00005361 Chemotherapy - Drug interaction    RC00008868

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-491-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-491-5p
Interactor2: DCAF12

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.