Detail Information

Basic Information:


  VIRBase ID:  

HHID00058654

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:           TRAM1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-491-5p TRAM1
miRBase
Accession/Entrez ID		 MIMAT0002807 23471
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PNAS8//TRAM//TRAMP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-491-5p
rs1302649663 chr9:20716133    TC/T
rs1443323273 chr9:20716132    T/G
rs563573084 chr9:20716129    C/T
rs760801072 chr9:20716135    C/T
rs768108997 chr9:20716130    C/T
rs773685607 chr9:20716134    C/G
rs773685607 chr9:20716134    C/T
rs774721604 chr9:20716128    A/T
rs1441505194 chr9:20716126    G/A
rs768906975 chr9:20716122    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRAM1
chr8:71488881(-) A-I      intronic
chr8:71488810(-) A-I      intronic
chr8:71487743(-) A-I      intronic
chr8:71487730(-) A-I      intronic
chr8:71488244(-) A-I      intronic
chr8:71494632(-) A-I      intronic
chr8:71503480(-) A-I      intronic
chr8:71516666(-) A-I      intronic
chr8:71489303(-) A-I      intronic
chr8:71500254(-) A-I      intronic
chr8:71500233(-) A-I      intronic
chr8:71499569(-) A-I      intronic
chr8:71494641(-) A-I      intronic
chr8:71494626(-) A-I      intronic
chr8:71490581(-) A-I      intronic
chr8:71488870(-) A-I      intronic
chr8:71494622(-) A-I      intronic
chr8:71490862(-) A-I      intronic
chr8:71490756(-) A-I      intronic
chr8:71487726(-) A-I      intronic
chr8:71490563(-) A-I      intronic
chr8:71490547(-) A-I      intronic
chr8:71503405(-) A-I      intronic
chr8:71490490(-) A-I      intronic
chr8:71503434(-) A-I      intronic
chr8:71490476(-) A-I      intronic
chr8:71502073(-) A-I      intronic
chr8:71503498(-) A-I      intronic
chr8:71489925(-) A-I      intronic
chr8:71489923(-) A-I      intronic
chr8:71489348(-) A-I      intronic
chr8:71489310(-) A-I      intronic
chr8:71488243(-) A-I      intronic
chr8:71502872(-) A-I      intronic
chr8:71494654(-) A-I      intronic
chr8:71503452(-) A-I      intronic
chr8:71490557(-) A-I      intronic
chr8:71487708(-) A-I      intronic
chr8:71490562(-) A-I      intronic
chr8:71490785(-) A-I      intronic
chr8:71493424(-) A-I      intronic
chr8:71488190(-) A-I      intronic
chr8:71487790(-) A-I      intronic
chr8:71500234(-) A-I      intronic
chr8:71488857(-) A-I      intronic
chr8:71516657(-) A-I      intronic
chr8:71499514(-) A-I      intronic
chr8:71490738(-) A-I      intronic
chr8:71494573(-) A-I      intronic
chr8:71490538(-) A-I      intronic
chr8:71488893(-) A-I      intronic
chr8:71487722(-) A-I      intronic
chr8:71490537(-) A-I      intronic
chr8:71488068(-) A-I      intronic
chr8:71488055(-) A-I      intronic
chr8:71490482(-) A-I      intronic
chr8:71499487(-) A-I      intronic
chr8:71502761(-) A-I      intronic
chr8:71490821(-) A-I      intronic
chr8:71500390(-) A-I      intronic
chr8:71487737(-) A-I      intronic
chr8:71500235(-) A-I      intronic
chr8:71490704(-) A-I      intronic
chr8:71502858(-) A-I      intronic
chr8:71487796(-) A-I      intronic
chr8:71490682(-) A-I      intronic
chr8:71502836(-) A-I      intronic
chr8:71490695(-) A-I      intronic
chr8:71488894(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRAM1
chr8:71488867(-) A-I intron -    22327324
chr8:71489273(-) A-I intron -    22327324
chr8:71489318(-) A-I intron -    22327324
chr8:71489320(-) A-I intron -    22327324
chr8:71489321(-) A-I intron -    22327324
chr8:71485679(-) C-A exon 3'UTR    21725310
chr8:71489273(-) A-G intron -    22484847
chr8:71489318(-) A-G intron -    22484847
chr8:71489319(-) A-G intron -    22484847
chr8:71489320(-) A-G intron -    22484847
chr8:71489321(-) A-G intron -    22484847
chr8:71489884(-) A-G intron -    22484847
chr8:71489893(-) A-G intron -    22484847
chr8:71489936(-) A-G intron -    22484847
chr8:71487708(-) A-G intron -    22484847
chr8:71487737(-) A-G intron -    22484847
chr8:71487796(-) A-G intron -    22484847
chr8:71488304(-) A-T intron -    22484847
chr8:71488867(-) A-G intron -    22484847
chr8:71490473(-) A-G intron -    22484847
chr8:71490538(-) A-G intron -    22484847
chr8:71490542(-) A-G intron -    22484847
chr8:71490665(-) A-G intron -    22484847
chr8:71490673(-) A-G intron -    22484847
chr8:71490682(-) A-G intron -    22484847
chr8:71490690(-) A-G intron -    22484847
chr8:71490695(-) A-G intron -    22484847
chr8:71490821(-) A-G intron -    22484847
chr8:71499514(-) A-G intron -    22484847
chr8:71500234(-) A-G intron -    22484847
chr8:71500235(-) A-G intron -    22484847
chr8:71502836(-) A-G intron -    22484847
chr8:71502858(-) A-G intron -    22484847
chr8:71503452(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRAM1
chr8:71486192-71486193(-) m6A 3'UTR       26404942
chr8:71486254-71486255(-) m6A 3'UTR       26404942
chr8:71486279-71486280(-) m6A 3'UTR       26404942
chr8:71486313-71486314(-) m6A 3'UTR       26404942
chr8:71486324-71486325(-) m6A 3'UTR       26404942
chr8:71486902-71486903(-) m6A 3'UTR       -
chr8:71486937-71486938(-) m6A 3'UTR       -
chr8:71486969-71486970(-) m6A 3'UTR       -
chr8:71519808-71519809(-) m6A 5'UTR//intron       27773536
chr8:71519900-71519901(-) m6A 5'UTR//intron       27773536
chr8:71519910-71519911(-) m6A 5'UTR//intron       27773536
chr8:71520360-71520361(-) m6A 5'UTR//CDS//exon//intron       27371828//27773536//22575960
chr8:71520474-71520475(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-491-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
TRAM1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-491-5p
Gemcitabine 60750 Drug interaction    RC00005366
Carboplatinum 38904 Drug interaction    RC00005365
Etoposide 36462 Drug interaction    RC00005364
Paclitaxel 36314 Drug interaction    RC00005363
5-Fluorouracil 3385 Drug interaction    RC00005360
Doxorubicin 31703 Drug interaction    RC00005362
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359
Verapamil 2520 Drug interaction    RC00005358
Arsenic trioxide 14888 Drug interaction    RC00005361
Chemotherapy - Drug interaction    RC00008868
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-491-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-491-5p
Interactor2: TRAM1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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