Basic Information:

  VIRBase ID:  

HHID00058641

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:  MIMAT0002807          CDC123:  NM_006023     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-491-5p	CDC123
miRBase Accession/Entrez ID	MIMAT0002807	8872
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf7//D123

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-491-5p	rs1302649663 chr9:20716133    TC/T rs1443323273 chr9:20716132    T/G rs563573084 chr9:20716129    C/T rs760801072 chr9:20716135    C/T rs768108997 chr9:20716130    C/T rs773685607 chr9:20716134    C/G rs773685607 chr9:20716134    C/T rs774721604 chr9:20716128    A/T rs1441505194 chr9:20716126    G/A rs768906975 chr9:20716122    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC123	chr10:12261383(+) A-I      intronic chr10:12292486(+) A-I      3'UTR chr10:12292487(+) A-I      3'UTR chr10:12292489(+) A-I      3'UTR chr10:12286858(+) A-I      intronic chr10:12261399(+) A-I      intronic chr10:12287381(+) A-I      intronic chr10:12248015(+) A-I      intronic chr10:12248843(+) A-I      intronic chr10:12247888(+) A-I      intronic chr10:12287367(+) A-I      intronic chr10:12287355(+) A-I      intronic chr10:12270626(+) A-I      intronic chr10:12247981(+) A-I      intronic chr10:12260506(+) A-I      intronic chr10:12248900(+) A-I      intronic chr10:12251336(+) A-I      intronic chr10:12286929(+) A-I      intronic chr10:12260289(+) A-I      intronic chr10:12260414(+) A-I      intronic chr10:12260423(+) A-I      intronic chr10:12260429(+) A-I      intronic chr10:12260442(+) A-I      intronic chr10:12286998(+) A-I      intronic chr10:12260477(+) A-I      intronic chr10:12264407(+) A-I      intronic chr10:12261412(+) A-I      intronic chr10:12261727(+) A-I      intronic chr10:12261949(+) A-I      intronic chr10:12261961(+) A-I      intronic chr10:12262788(+) A-I      intronic chr10:12260265(+) A-I      intronic chr10:12264372(+) A-I      intronic chr10:12265030(+) A-I      intronic chr10:12265078(+) A-I      intronic chr10:12265097(+) A-I      intronic chr10:12287918(+) A-I      intronic chr10:12265100(+) A-I      intronic chr10:12287485(+) A-I      intronic chr10:12242401(+) A-I      intronic chr10:12252880(+) A-I      intronic chr10:12265115(+) A-I      intronic chr10:12252836(+) A-I      intronic chr10:12270699(+) A-I      intronic chr10:12252865(+) A-I      intronic chr10:12270727(+) A-I      intronic chr10:12272321(+) A-I      intronic chr10:12280646(+) A-I      intronic chr10:12280665(+) A-I      intronic chr10:12280693(+) A-I      intronic chr10:12287994(+) A-I      intronic chr10:12285689(+) A-I      intronic chr10:12287975(+) A-I      intronic chr10:12248918(+) A-I      intronic chr10:12287962(+) A-I      intronic chr10:12287919(+) A-I      intronic chr10:12287869(+) A-I      intronic chr10:12251621(+) A-I      intronic chr10:12259925(+) A-I      intronic chr10:12242195(+) A-I      intronic chr10:12287815(+) A-I      intronic chr10:12287384(+) A-I      intronic chr10:12287954(+) A-I      intronic chr10:12242731(+) A-I      intronic chr10:12287372(+) A-I      intronic chr10:12286914(+) A-I      intronic chr10:12286830(+) A-I      intronic chr10:12242773(+) A-I      intronic chr10:12242779(+) A-I      intronic chr10:12241960(+) A-I      intronic chr10:12242027(+) A-I      intronic chr10:12286801(+) A-I      intronic chr10:12259922(+) A-I      intronic chr10:12259929(+) A-I      intronic chr10:12252804(+) A-I      intronic chr10:12246845(+) A-I      intronic chr10:12244849(+) A-I      intronic chr10:12251508(+) A-I      intronic chr10:12251716(+) A-I      intronic chr10:12286798(+) A-I      intronic chr10:12247898(+) A-I      intronic chr10:12252774(+) A-I      intronic chr10:12251725(+) A-I      intronic chr10:12246885(+) A-I      intronic chr10:12251634(+) A-I      intronic chr10:12251846(+) A-I      intronic chr10:12251823(+) A-I      intronic chr10:12286861(+) A-I      intronic chr10:12251747(+) A-I      intronic chr10:12285698(+) A-I      intronic chr10:12245863(+) A-I      intronic chr10:12246894(+) A-I      intronic chr10:12251740(+) A-I      intronic chr10:12247829(+) A-I      intronic chr10:12280650(+) A-I      intronic chr10:12284945(+) A-I      intronic chr10:12251837(+) A-I      intronic chr10:12264809(+) A-I      intronic chr10:12260440(+) A-I      intronic chr10:12286776(+) A-I      intronic chr10:12252829(+) A-I      intronic chr10:12245927(+) A-I      intronic chr10:12259837(+) A-I      intronic chr10:12270879(+) A-I      intronic chr10:12286893(+) A-I      intronic chr10:12262789(+) A-I      intronic chr10:12270469(+) A-I      intronic chr10:12242377(+) A-I      intronic chr10:12287948(+) A-I      intronic chr10:12252800(+) A-I      intronic chr10:12252799(+) A-I      intronic chr10:12287319(+) A-I      intronic chr10:12270647(+) A-I      intronic chr10:12251305(+) A-I      intronic chr10:12251774(+) A-I      intronic chr10:12270988(+) A-I      intronic chr10:12248640(+) A-I      intronic chr10:12287388(+) A-I      intronic chr10:12244971(+) A-I      intronic chr10:12287270(+) A-I      intronic chr10:12260378(+) A-I      intronic chr10:12247937(+) A-I      intronic chr10:12285178(+) A-I      intronic chr10:12251753(+) A-I      intronic chr10:12245887(+) A-I      intronic chr10:12260277(+) A-I      intronic chr10:12248716(+) A-I      intronic chr10:12259973(+) A-I      intronic chr10:12274876(+) A-I      intronic chr10:12260356(+) A-I      intronic chr10:12244871(+) A-I      intronic chr10:12252874(+) A-I      intronic chr10:12287478(+) A-I      intronic chr10:12260315(+) A-I      intronic chr10:12248903(+) A-I      intronic chr10:12251764(+) A-I      intronic chr10:12252723(+) A-I      intronic chr10:12260412(+) A-I      intronic chr10:12281853(+) A-I      intronic chr10:12261874(+) A-I      intronic chr10:12287861(+) A-I      intronic chr10:12287331(+) A-I      intronic chr10:12252793(+) A-I      intronic chr10:12251676(+) A-I      intronic chr10:12270897(+) A-I      intronic chr10:12262855(+) A-I      intronic chr10:12242857(+) A-I      intronic chr10:12287491(+) A-I      intronic chr10:12270460(+) A-I      intronic chr10:12264364(+) A-I      intronic chr10:12286897(+) A-I      intronic chr10:12287508(+) A-I      intronic chr10:12259990(+) A-I      intronic chr10:12251630(+) A-I      intronic chr10:12287814(+) A-I      intronic chr10:12287322(+) A-I      intronic chr10:12262823(+) A-I      intronic chr10:12260074(+) A-I      intronic chr10:12264817(+) A-I      intronic chr10:12270952(+) A-I      intronic chr10:12287530(+) A-I      intronic chr10:12252883(+) A-I      intronic chr10:12242829(+) A-I      intronic chr10:12261748(+) A-I      intronic chr10:12260339(+) A-I      intronic chr10:12267178(+) A-I      intronic chr10:12287427(+) A-I      intronic chr10:12261823(+) A-I      intronic chr10:12260368(+) A-I      intronic chr10:12241891(+) A-I      intronic chr10:12260029(+) A-I      intronic chr10:12246907(+) A-I      intronic chr10:12273517(+) A-I      intronic chr10:12267179(+) A-I      intronic chr10:12252839(+) A-I      intronic chr10:12259903(+) A-I      intronic chr10:12262816(+) A-I      intronic chr10:12242834(+) A-I      intronic chr10:12286843(+) A-I      intronic chr10:12242399(+) A-I      intronic chr10:12270914(+) A-I      intronic chr10:12245945(+) A-I      intronic chr10:12251768(+) A-I      intronic chr10:12245971(+) A-I      intronic chr10:12261402(+) A-I      intronic chr10:12270709(+) A-I      intronic chr10:12287358(+) A-I      intronic chr10:12287394(+) A-I      intronic chr10:12286888(+) A-I      intronic chr10:12247897(+) A-I      intronic chr10:12286829(+) A-I      intronic chr10:12252889(+) A-I      intronic chr10:12248658(+) A-I      intronic chr10:12244933(+) A-I      intronic chr10:12262865(+) A-I      intronic chr10:12259905(+) A-I      intronic chr10:12251703(+) A-I      intronic chr10:12251639(+) A-I      intronic chr10:12245850(+) A-I      intronic chr10:12253967(+) A-I      intronic chr10:12287922(+) A-I      intronic chr10:12260343(+) A-I      intronic chr10:12248539(+) A-I      intronic chr10:12281723(+) A-I      intronic chr10:12279562(+) A-I      intronic chr10:12267208(+) A-I      intronic chr10:12284872(+) A-I      intronic chr10:12264784(+) A-I      intronic chr10:12269626(+) A-I      intronic chr10:12270749(+) A-I      intronic chr10:12287465(+) A-I      intronic chr10:12287453(+) A-I      intronic chr10:12251629(+) A-I      intronic chr10:12241939(+) A-I      intronic chr10:12260055(+) A-I      intronic chr10:12261813(+) A-I      intronic chr10:12246920(+) A-I      intronic chr10:12251831(+) A-I      intronic chr10:12270600(+) A-I      intronic chr10:12241987(+) A-I      intronic chr10:12276158(+) A-I      intronic chr10:12259965(+) A-I      intronic chr10:12259792(+) A-I      intronic chr10:12259795(+) A-I      intronic chr10:12265167(+) A-I      intronic chr10:12259790(+) A-I      intronic chr10:12262829(+) A-I      intronic chr10:12287917(+) A-I      intronic chr10:12273462(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC123	chr10:12286829(+) A-I intron -    22327324 chr10:12287322(+) A-I intron -    22327324 chr10:12287388(+) A-I intron -    22327324 chr10:12287948(+) A-I intron -    22327324 chr10:12242377(+) A-G intron -    22484847 chr10:12242399(+) A-G intron -    22484847 chr10:12242401(+) A-G intron -    22484847 chr10:12245850(+) A-G intron -    22484847 chr10:12251764(+) A-G intron -    22484847 chr10:12251768(+) A-G intron -    22484847 chr10:12251774(+) A-G intron -    22484847 chr10:12262855(+) A-G intron -    22484847 chr10:12262865(+) A-G intron -    22484847 chr10:12280650(+) A-G intron -    22484847 chr10:12280826(+) C-T intron -    22484847 chr10:12285282(+) A-C intron -    22484847 chr10:12285283(+) G-C intron -    22484847 chr10:12286798(+) A-G intron -    22484847 chr10:12286829(+) A-G intron -    22484847 chr10:12287322(+) A-G intron -    22484847 chr10:12287367(+) A-G intron -    22484847 chr10:12287388(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC123	chr10:12237992-12237993(+) m6A 5'UTR       24981863//27773535//22608085 chr10:12238039-12238040(+) m6A 5'UTR//intron       24981863//27773535//22608085 chr10:12238130-12238131(+) m6A 5'UTR//exon       25456834//24981863//27773535//22608085 chr10:12238147-12238148(+) m6A 5'UTR//exon       25456834//24981863//22608085 chr10:12238250-12238251(+) m1A CDS//exon       26863196//26863410 chr10:12240755-12240756(+) m6A CDS//exon       24981863 chr10:12251994-12251995(+) m6A CDS//exon       - chr10:12252304-12252305(+) m6A CDS//exon       - chr10:12277110-12277111(+) m6A CDS//exon       27773535 chr10:12279157-12279158(+) m6A CDS//exon//intron       27773535 chr10:12279188-12279189(+) m6A CDS//exon//intron       27773535 chr10:12279220-12279221(+) m6A CDS//exon//intron       27773535 chr10:12279233-12279234(+) m6A CDS//exon//intron       27773535 chr10:12279262-12279263(+) m6A CDS//exon//intron       27773535 chr10:12292349-12292350(+) m6A 3'UTR//exon       - chr10:12292444-12292445(+) m6A 3'UTR//exon       - chr10:12292539-12292540(+) m6A 3'UTR       24981863 chr10:12292549-12292550(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-491-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	CDC123	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-491-5p	Gemcitabine 60750 Drug interaction    RC00005366 Carboplatinum 38904 Drug interaction    RC00005365 Etoposide 36462 Drug interaction    RC00005364 Paclitaxel 36314 Drug interaction    RC00005363 5-Fluorouracil 3385 Drug interaction    RC00005360 Doxorubicin 31703 Drug interaction    RC00005362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359 Verapamil 2520 Drug interaction    RC00005358 Arsenic trioxide 14888 Drug interaction    RC00005361 Chemotherapy - Drug interaction    RC00008868

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-491-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-491-5p
Interactor2: CDC123

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.