Detail Information

Basic Information:


  VIRBase ID:  

HHID00058638

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-491-5p:           TAGLN2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-491-5p TAGLN2
miRBase
Accession/Entrez ID		 MIMAT0002807 8407
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HA1756

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-491-5p
rs1302649663 chr9:20716133    TC/T
rs1443323273 chr9:20716132    T/G
rs563573084 chr9:20716129    C/T
rs760801072 chr9:20716135    C/T
rs768108997 chr9:20716130    C/T
rs773685607 chr9:20716134    C/G
rs773685607 chr9:20716134    C/T
rs774721604 chr9:20716128    A/T
rs1441505194 chr9:20716126    G/A
rs768906975 chr9:20716122    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TAGLN2
chr1:159888141-159888142(-) m6A 3'UTR       24284625
chr1:159888191-159888192(-) m6A 3'UTR       24284625//22575960
chr1:159888344-159888345(-) m6A 3'UTR       24284625//27773535//22575960
chr1:159888372-159888373(-) m6A 3'UTR       24284625//27773535//22575960
chr1:159888377-159888378(-) m6A 3'UTR       24284625//27773535//22575960
chr1:159888707-159888708(-) m6A CDS//exon       26404942
chr1:159889047-159889048(-) m6A exon//intron       24284625
chr1:159889159-159889160(-) m6A CDS//exon       24284625//26404942
chr1:159889461-159889462(-) m6A CDS//exon       24284625//26404942
chr1:159889468-159889469(-) m6A CDS//exon       24284625//26404942
chr1:159890138-159890139(-) m6A CDS//exon       22575960
chr1:159890147-159890148(-) m6A CDS//exon       22575960
chr1:159890239-159890240(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:159890284-159890285(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:159893286-159893287(-) m6A 5'UTR//intron       24284625//25456834//24981863//28052920//27371828//22608085
chr1:159893301-159893302(-) m6A 5'UTR//intron       24284625//25456834//24981863//28052920//27371828//22608085
chr1:159894918-159894919(-) m6A 5'UTR//intron       -
chr1:159894984-159894985(-) m6A 5'UTR//intron       24981863
chr1:159894992-159894993(-) m6A 5'UTR//intron       24981863
chr1:159895016-159895017(-) m6A 5'UTR//intron       24981863
chr1:159895332-159895333(-) m6A 5'UTR       24981863
chr1:159895380-159895381(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-491-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
TAGLN2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-491-5p
Gemcitabine 60750 Drug interaction    RC00005366
Carboplatinum 38904 Drug interaction    RC00005365
Etoposide 36462 Drug interaction    RC00005364
Paclitaxel 36314 Drug interaction    RC00005363
5-Fluorouracil 3385 Drug interaction    RC00005360
Doxorubicin 31703 Drug interaction    RC00005362
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005359
Verapamil 2520 Drug interaction    RC00005358
Arsenic trioxide 14888 Drug interaction    RC00005361
Chemotherapy - Drug interaction    RC00008868
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-491-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-491-5p
Interactor2: TAGLN2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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