Basic Information:

  VIRBase ID:  

HHID00058611

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-486-5p:  MIMAT0002177          SIRT1:  NM_001314049     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-486-5p	SIRT1
miRBase Accession/Entrez ID	MIMAT0002177	23411
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SIR2//SIR2alpha//SIR2L1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-486-5p	rs1044221050 chr8:41660453    G/A rs1044221050 chr8:41660453    G/C rs1044221050 chr8:41660453    G/T rs1214959222 chr8:41660486    C/T rs1245094673 chr8:41660505    A/G rs1404913611 chr8:41660464    A/AGGCCCTTCAT rs1407060911 chr8:41660452    T/C rs1444176912 chr8:41660444    T/A rs1461093579 chr8:41660495    T/C rs558947995 chr8:41660463    G/A rs558947995 chr8:41660463    G/T rs1013196158 chr8:41660447    T/C rs1181833624 chr8:41660445    C/A rs1201993790 chr8:41660498    G/A rs1387158920 chr8:41660449    T/C rs539160181 chr8:41660456    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SIRT1	chr10:69652499(+) A-I      intronic chr10:69652073(+) A-I      intronic chr10:69657868(+) A-I      intronic chr10:69657889(+) A-I      intronic chr10:69657902(+) A-I      intronic chr10:69657910(+) A-I      intronic chr10:69659824(+) A-I      intronic chr10:69645898(+) A-I      intronic chr10:69659826(+) A-I      intronic chr10:69660085(+) A-I      intronic chr10:69664003(+) A-I      intronic chr10:69656771(+) A-I      intronic chr10:69656738(+) A-I      intronic chr10:69656694(+) A-I      intronic chr10:69656402(+) A-I      intronic chr10:69656395(+) A-I      intronic chr10:69661020(+) A-I      intronic chr10:69655106(+) A-I      intronic chr10:69656394(+) A-I      intronic chr10:69656189(+) A-I      intronic chr10:69656184(+) A-I      intronic chr10:69656182(+) A-I      intronic chr10:69670044(+) A-I      intronic chr10:69656178(+) A-I      intronic chr10:69655680(+) A-I      intronic chr10:69655604(+) A-I      intronic chr10:69655603(+) A-I      intronic chr10:69655594(+) A-I      intronic chr10:69655073(+) A-I      intronic chr10:69653804(+) A-I      intronic chr10:69655065(+) A-I      intronic chr10:69655032(+) A-I      intronic chr10:69654939(+) A-I      intronic chr10:69654594(+) A-I      intronic chr10:69654567(+) A-I      intronic chr10:69660940(+) A-I      intronic chr10:69653808(+) A-I      intronic chr10:69657069(+) A-I      intronic chr10:69652460(+) A-I      intronic chr10:69652158(+) A-I      intronic chr10:69652114(+) A-I      intronic chr10:69652095(+) A-I      intronic chr10:69652074(+) A-I      intronic chr10:69650498(+) A-I      intronic chr10:69650364(+) A-I      intronic chr10:69657324(+) A-I      intronic chr10:69663998(+) A-I      intronic chr10:69650283(+) A-I      intronic chr10:69659656(+) A-I      intronic chr10:69650016(+) A-I      intronic chr10:69649997(+) A-I      intronic chr10:69649971(+) A-I      intronic chr10:69649918(+) A-I      intronic chr10:69649914(+) A-I      intronic chr10:69647514(+) A-I      intronic chr10:69646302(+) A-I      intronic chr10:69646266(+) A-I      intronic chr10:69646233(+) A-I      intronic chr10:69664117(+) A-I      intronic chr10:69653383(+) A-I      intronic chr10:69657871(+) A-I      intronic chr10:69657920(+) A-I      intronic chr10:69659763(+) A-I      intronic chr10:69661032(+) A-I      intronic chr10:69657832(+) A-I      intronic chr10:69657923(+) A-I      intronic chr10:69646186(+) A-I      intronic chr10:69657896(+) A-I      intronic chr10:69657811(+) A-I      intronic chr10:69649943(+) A-I      intronic chr10:69646293(+) A-I      intronic chr10:69646795(+) A-I      intronic chr10:69650727(+) A-I      intronic chr10:69657151(+) A-I      intronic chr10:69669351(+) A-I      intronic chr10:69650677(+) A-I      intronic chr10:69655069(+) A-I      intronic chr10:69656728(+) A-I      intronic chr10:69660290(+) A-I      intronic chr10:69662953(+) A-I      intronic chr10:69657319(+) A-I      intronic chr10:69659948(+) A-I      intronic chr10:69661003(+) A-I      intronic chr10:69669461(+) A-I      intronic chr10:69664481(+) A-I      intronic chr10:69654945(+) A-I      intronic chr10:69656793(+) A-I      intronic chr10:69657840(+) A-I      intronic chr10:69671084(+) A-I      intronic chr10:69654716(+) A-I      intronic chr10:69671054(+) A-I      intronic chr10:69656680(+) A-I      intronic chr10:69654715(+) A-I      intronic chr10:69657809(+) A-I      intronic chr10:69657859(+) A-I      intronic chr10:69657841(+) A-I      intronic chr10:69657810(+) A-I      intronic chr10:69652204(+) A-I      intronic chr10:69656304(+) A-I      intronic chr10:69671038(+) A-I      intronic chr10:69656392(+) A-I      intronic chr10:69662768(+) A-I      intronic chr10:69657962(+) A-I      intronic chr10:69657945(+) A-I      intronic chr10:69671037(+) A-I      intronic chr10:69671020(+) A-I      intronic chr10:69670064(+) A-I      intronic chr10:69670021(+) A-I      intronic chr10:69654996(+) A-I      intronic chr10:69654641(+) A-I      intronic chr10:69664331(+) A-I      intronic chr10:69669882(+) A-I      intronic chr10:69664546(+) A-I      intronic chr10:69664522(+) A-I      intronic chr10:69659655(+) A-I      intronic chr10:69664516(+) A-I      intronic chr10:69664507(+) A-I      intronic chr10:69664494(+) A-I      intronic chr10:69664455(+) A-I      intronic chr10:69664427(+) A-I      intronic chr10:69664364(+) A-I      intronic chr10:69646259(+) A-I      intronic chr10:69664084(+) A-I      intronic chr10:69657977(+) A-I      intronic chr10:69664078(+) A-I      intronic chr10:69663946(+) A-I      intronic chr10:69649953(+) A-I      intronic chr10:69663401(+) A-I      intronic chr10:69660245(+) A-I      intronic chr10:69663392(+) A-I      intronic chr10:69663330(+) A-I      intronic chr10:69663269(+) A-I      intronic chr10:69663220(+) A-I      intronic chr10:69663211(+) A-I      intronic chr10:69661008(+) A-I      intronic chr10:69660936(+) A-I      intronic chr10:69657219(+) A-I      intronic chr10:69660150(+) A-I      intronic chr10:69660004(+) A-I      intronic chr10:69657937(+) A-I      intronic chr10:69660003(+) A-I      intronic chr10:69659754(+) A-I      intronic chr10:69654585(+) A-I      intronic chr10:69657942(+) A-I      intronic chr10:69659664(+) A-I      intronic chr10:69659654(+) A-I      intronic chr10:69658042(+) A-I      intronic chr10:69657929(+) A-I      intronic chr10:69657867(+) A-I      intronic chr10:69657441(+) A-I      intronic chr10:69657305(+) A-I      intronic chr10:69657302(+) A-I      intronic chr10:69657288(+) A-I      intronic chr10:69656835(+) A-I      intronic chr10:69657240(+) A-I      intronic chr10:69657252(+) A-I      intronic chr10:69669885(+) A-I      intronic chr10:69657264(+) A-I      intronic chr10:69656794(+) A-I      intronic chr10:69660038(+) A-I      intronic chr10:69654572(+) A-I      intronic chr10:69658473(+) A-I      intronic chr10:69659837(+) A-I      intronic chr10:69653777(+) A-I      intronic chr10:69646227(+) A-I      intronic chr10:69660137(+) A-I      intronic chr10:69656406(+) A-I      intronic chr10:69663352(+) A-I      intronic chr10:69657436(+) A-I      intronic chr10:69660259(+) A-I      intronic chr10:69670011(+) A-I      intronic chr10:69669970(+) A-I      intronic chr10:69653468(+) A-I      intronic chr10:69662597(+) A-I      intronic chr10:69653778(+) A-I      intronic chr10:69657439(+) A-I      intronic chr10:69657150(+) A-I      intronic chr10:69664185(+) A-I      intronic chr10:69654706(+) A-I      intronic chr10:69649979(+) A-I      intronic chr10:69650550(+) A-I      intronic chr10:69664402(+) A-I      intronic chr10:69652382(+) A-I      intronic chr10:69669976(+) A-I      intronic chr10:69655093(+) A-I      intronic chr10:69646165(+) A-I      intronic chr10:69660165(+) A-I      intronic chr10:69650086(+) A-I      intronic chr10:69657262(+) A-I      intronic chr10:69649940(+) A-I      intronic chr10:69664025(+) A-I      intronic chr10:69659915(+) A-I      intronic chr10:69652477(+) A-I      intronic chr10:69664052(+) A-I      intronic chr10:69657518(+) A-I      intronic chr10:69657382(+) A-I      intronic chr10:69657416(+) A-I      intronic chr10:69662728(+) A-I      intronic chr10:69649931(+) A-I      intronic chr10:69663260(+) A-I      intronic chr10:69646096(+) A-I      intronic chr10:69662667(+) A-I      intronic chr10:69669985(+) A-I      intronic chr10:69659727(+) A-I      intronic chr10:69662985(+) A-I      intronic chr10:69657932(+) A-I      intronic chr10:69660164(+) A-I      intronic chr10:69656727(+) A-I      intronic chr10:69664133(+) A-I      intronic chr10:69662722(+) A-I      intronic chr10:69650527(+) A-I      intronic chr10:69655574(+) A-I      intronic chr10:69646141(+) A-I      intronic chr10:69664348(+) A-I      intronic chr10:69646104(+) A-I      intronic chr10:69663407(+) A-I      intronic chr10:69654992(+) A-I      intronic chr10:69662666(+) A-I      intronic chr10:69650586(+) A-I      intronic chr10:69671080(+) A-I      intronic chr10:69652233(+) A-I      intronic chr10:69653764(+) A-I      intronic chr10:69662761(+) A-I      intronic chr10:69653795(+) A-I      intronic chr10:69653503(+) A-I      intronic chr10:69652543(+) A-I      intronic chr10:69654597(+) A-I      intronic chr10:69652489(+) A-I      intronic chr10:69654667(+) A-I      intronic chr10:69657842(+) A-I      intronic chr10:69659721(+) A-I      intronic chr10:69652210(+) A-I      intronic chr10:69645759(+) A-I      intronic chr10:69660065(+) A-I      intronic chr10:69650344(+) A-I      intronic chr10:69645881(+) A-I      intronic chr10:69663916(+) A-I      intronic chr10:69645830(+) A-I      intronic chr10:69646198(+) A-I      intronic chr10:69654728(+) A-I      intronic chr10:69655577(+) A-I      intronic chr10:69646169(+) A-I      intronic chr10:69656391(+) A-I      intronic chr10:69664498(+) A-I      intronic chr10:69656829(+) A-I      intronic chr10:69645884(+) A-I      intronic chr10:69654999(+) A-I      intronic chr10:69659927(+) A-I      intronic chr10:69669471(+) A-I      intronic chr10:69655109(+) A-I      intronic chr10:69656093(+) A-I      intronic chr10:69663406(+) A-I      intronic chr10:69650247(+) A-I      intronic chr10:69663985(+) A-I      intronic chr10:69661030(+) A-I      intronic chr10:69650603(+) A-I      intronic chr10:69655019(+) A-I      intronic chr10:69646095(+) A-I      intronic chr10:69657857(+) A-I      intronic chr10:69659632(+) A-I      intronic chr10:69661077(+) A-I      intronic chr10:69652147(+) A-I      intronic chr10:69653380(+) A-I      intronic chr10:69660029(+) A-I      intronic chr10:69659748(+) A-I      intronic chr10:69655082(+) A-I      intronic chr10:69646255(+) A-I      intronic chr10:69669971(+) A-I      intronic chr10:69656393(+) A-I      intronic chr10:69660303(+) A-I      intronic chr10:69656276(+) A-I      intronic chr10:69664012(+) A-I      intronic chr10:69669721(+) A-I      intronic chr10:69660045(+) A-I      intronic chr10:69656767(+) A-I      intronic chr10:69659565(+) A-I      intronic chr10:69659744(+) A-I      intronic chr10:69656400(+) A-I      intronic chr10:69659762(+) A-I      intronic chr10:69663281(+) A-I      intronic chr10:69657490(+) A-I      intronic chr10:69652501(+) A-I      intronic chr10:69649955(+) A-I      intronic chr10:69656465(+) A-I      intronic chr10:69657834(+) A-I      intronic chr10:69656103(+) A-I      intronic chr10:69662801(+) A-I      intronic chr10:69650370(+) A-I      intronic chr10:69654542(+) A-I      intronic chr10:69652241(+) A-I      intronic chr10:69654593(+) A-I      intronic chr10:69652148(+) A-I      intronic chr10:69650539(+) A-I      intronic chr10:69669737(+) A-I      intronic chr10:69654923(+) A-I      intronic chr10:69652139(+) A-I      intronic chr10:69657499(+) A-I      intronic chr10:69663344(+) A-I      intronic chr10:69664130(+) A-I      intronic chr10:69659879(+) A-I      intronic chr10:69650384(+) A-I      intronic chr10:69656445(+) A-I      intronic chr10:69659878(+) A-I      intronic chr10:69657897(+) A-I      intronic chr10:69646053(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SIRT1	chr10:69657809(+) A-I intron -    22028664 chr10:69657810(+) A-I intron -    22028664 chr10:69657811(+) A-I intron -    22028664 chr10:69657832(+) A-I intron -    22028664 chr10:69657834(+) A-I intron -    22028664 chr10:69657840(+) A-I intron -    22028664 chr10:69657841(+) A-I intron -    22028664 chr10:69657842(+) A-I intron -    22028664 chr10:69657859(+) A-I intron -    22028664 chr10:69657896(+) A-I intron -    22028664 chr10:69657897(+) A-I intron -    22028664 chr10:69657920(+) A-I intron -    22028664 chr10:69657923(+) A-I intron -    22028664 chr10:69657932(+) A-I intron -    22028664 chr10:69657937(+) A-I intron -    22028664 chr10:69657942(+) A-I intron -    22028664 chr10:69657945(+) A-I intron -    22028664 chr10:69657962(+) A-I intron -    22028664 chr10:69657977(+) A-I intron -    22028664 chr10:69652210(+) A-I intron -    21960545 chr10:69661008(+) A-I intron -    21960545 chr10:69650603(+) A-G intron -    22484847 chr10:69664117(+) A-G intron -    22484847 chr10:69664130(+) A-G intron -    22484847 chr10:69671054(+) A-G intron -    22484847 chr10:69671080(+) A-G intron -    22484847 chr10:69671084(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIRT1	chr10:69644783-69644784(+) m6A CDS       24284625//24209618//24981863//22575960 chr10:69669179-69669180(+) m6A CDS       24284625 chr10:69672273-69672274(+) m6A CDS       24284625//24981863//26404942//22608085 chr10:69672314-69672315(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672369-69672370(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672411-69672412(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672421-69672422(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672482-69672483(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672502-69672503(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672542-69672543(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672606-69672607(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672622-69672623(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr10:69672651-69672652(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr10:69672712-69672713(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69672727-69672728(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676084-69676085(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676140-69676141(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676166-69676167(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676260-69676261(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676307-69676308(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676321-69676322(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676327-69676328(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676339-69676340(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676395-69676396(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676429-69676430(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr10:69676447-69676448(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:69676534-69676535(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-486-5p	Cytoplasm Gastric adenocarcinoma cells     25793394 Exosome Pooled sera     27278097 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome Peripheral blood mononuclear cells     19002258 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24130905 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Kidney tissue|Lymphoma tissue|Mast cells     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Liver resident stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SIRT1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-486-5p	Iodine Green 9956454 Drug sensitive Gardenin B 96539 Drug sensitive Neocuproine 65237 Drug sensitive 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-6-[(1R)-2-amino-1-phenylethoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol;2,2,2-trifluoroacetic acid 56604034 Drug sensitive 2-Azaadenine 5480214 Drug resistant (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Chaetochromin 53277 Drug sensitive Propyl gallate 4947 Drug resistant N-Methyl-1,5-bis(4-cyanophenoxy)-3-aza-pentane 45028719 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive ARQ monoacetate 385441 Drug sensitive (1R)-3,3-Dibromocamphor 376765 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive 1-octene, 3-(bromomethyl)-2,3,7-trichloro-7-methyl- - Drug resistant vernonioside c - Drug resistant 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 5-methoxy camptothecin - Drug sensitive antineoplastic-641296 - Drug sensitive organosulfur compound - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-486-5p	Cianidanol 9064 Drug interaction    RC00005333 Alocrest 60780 Drug interaction    RC00005338 Gemcitabine 60750 Drug interaction    RC00005337 Vincristine 5978 Drug interaction    RC00005332 Imatinib 5291 Drug interaction    RC00005331 Trichostatin A 444732 Drug interaction    RC00005344 Naringin 442428 Drug interaction    RC00005343 Paroxetine 43815 Drug interaction    RC00005336 5-Fluorouracil 3385 Drug interaction    RC00005330 Doxorubicin 31703 Drug interaction    RC00005335 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005329 Docetaxel 148124 Drug interaction    RC00005342 Flavylium 145858 Drug interaction    RC00005341 Ginsenoside Rh2 119307 Drug interaction    RC00005340 Proanthocyanidin 108065 Drug interaction    RC00005339 Hesperidin 10621 Drug interaction    RC00005334

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-486-5p
Interactor2: SIRT1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.