Basic Information:

  VIRBase ID:  

HHID00058599

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          UNC13C:  NM_001080534     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	UNC13C
miRBase Accession/Entrez ID	MIMAT0001541	440279
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UNC13C	chr15:54662266(+) A-I      intronic chr15:54334903(+) A-I      intronic chr15:54417962(+) A-I      intronic chr15:54418050(+) A-I      intronic chr15:54418553(+) A-I      intronic chr15:54392177(+) A-I      intronic chr15:54450579(+) A-I      intronic chr15:54405912(+) A-I      intronic chr15:54405860(+) A-I      intronic chr15:54401632(+) A-I      intronic chr15:54418612(+) A-I      intronic chr15:54418615(+) A-I      intronic chr15:54401625(+) A-I      intronic chr15:54393966(+) A-I      intronic chr15:54418630(+) A-I      intronic chr15:54418692(+) A-I      intronic chr15:54418696(+) A-I      intronic chr15:54472517(+) A-I      intronic chr15:54500481(+) A-I      intronic chr15:54632011(+) A-I      intronic chr15:54633210(+) A-I      intronic chr15:54633302(+) A-I      intronic chr15:54633316(+) A-I      intronic chr15:54899806(+) A-I      intronic chr15:54899824(+) A-I      intronic chr15:54392174(+) A-I      intronic chr15:54662201(+) A-I      intronic chr15:54330432(+) A-I      intronic chr15:54393872(+) A-I      intronic chr15:54700278(+) A-I      intronic chr15:54479185(+) A-I      intronic chr15:54453370(+) A-I      intronic chr15:54635461(+) A-I      intronic chr15:54453346(+) A-I      intronic chr15:54405955(+) A-I      intronic chr15:54317053(+) A-I      intronic chr15:54396125(+) A-I      intronic chr15:54501663(+) A-I      intronic chr15:54635471(+) A-I      intronic chr15:54453349(+) A-I      intronic chr15:54454024(+) A-I      intronic chr15:54393919(+) A-I      intronic chr15:54663166(+) A-I      intronic chr15:54663279(+) A-I      intronic chr15:54396043(+) A-I      intronic chr15:54454030(+) A-I      intronic chr15:54459512(+) A-I      intronic chr15:54632007(+) A-I      intronic chr15:54587734(+) A-I      intronic chr15:54330424(+) A-I      intronic chr15:54459539(+) A-I      intronic chr15:54632051(+) A-I      intronic chr15:54899893(+) A-I      intronic chr15:54393882(+) A-I      intronic chr15:54663286(+) A-I      intronic chr15:54634053(+) A-I      intronic chr15:54663216(+) A-I      intronic chr15:54453396(+) A-I      intronic chr15:54632052(+) A-I      intronic chr15:54858525(+) A-I      intronic chr15:54634063(+) A-I      intronic chr15:54393858(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UNC13C	chr15:54305630-54305631(+) m6A CDS       - chr15:54305648-54305649(+) m6A CDS       - chr15:54305689-54305690(+) m6A CDS       - chr15:54305743-54305744(+) m6A CDS       27773535 chr15:54305748-54305749(+) m6A CDS       27773535 chr15:54305758-54305759(+) m6A CDS       27773535 chr15:54305766-54305767(+) m6A CDS       27773535//22575960 chr15:54305814-54305815(+) m6A CDS       27773535//22575960 chr15:54305846-54305847(+) m6A CDS       27773535//22575960 chr15:54305871-54305872(+) m6A CDS       27773535//22575960 chr15:54305876-54305877(+) m6A CDS       27773535//22575960 chr15:54305885-54305886(+) m6A CDS       22575960 chr15:54306847-54306848(+) m6A CDS       27773535//22575960 chr15:54306869-54306870(+) m6A CDS       27773535//22575960 chr15:54306879-54306880(+) m6A CDS       27773535//22575960 chr15:54306907-54306908(+) m6A CDS       27773535//22575960 chr15:54306948-54306949(+) m6A CDS       27773535//22575960 chr15:54306954-54306955(+) m6A CDS       27773535//22575960 chr15:54306961-54306962(+) m6A CDS       27773535//22575960 chr15:54306969-54306970(+) m6A CDS       27773535//22575960 chr15:54307015-54307016(+) m6A CDS       - chr15:54307537-54307538(+) m6A CDS       27773535//22575960 chr15:54307570-54307571(+) m6A CDS       27773535//22575960 chr15:54307602-54307603(+) m6A CDS       27773535//22575960 chr15:54307706-54307707(+) m6A CDS       27773535 chr15:54307725-54307726(+) m6A CDS       27773535 chr15:54307748-54307749(+) m6A CDS       27773535 chr15:54307763-54307764(+) m6A CDS       27773535 chr15:54307771-54307772(+) m6A CDS       27773535 chr15:54307776-54307777(+) m6A CDS       27773535 chr15:54307791-54307792(+) m6A CDS       27773535 chr15:54307799-54307800(+) m6A CDS       27773535 chr15:54307833-54307834(+) m6A CDS       27773535 chr15:54307845-54307846(+) m6A CDS       27773535 chr15:54307907-54307908(+) m6A CDS       27773535 chr15:54307920-54307921(+) m6A CDS       27773535 chr15:54307954-54307955(+) m6A CDS       27773535 chr15:54307960-54307961(+) m6A CDS       27773535 chr15:54307970-54307971(+) m6A CDS       27773535 chr15:54919138-54919139(+) m6A CDS       - chr15:54919203-54919204(+) m6A CDS       - chr15:54919239-54919240(+) m6A CDS       - chr15:54919271-54919272(+) m6A CDS       - chr15:54919284-54919285(+) m6A CDS       - chr15:54919312-54919313(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	UNC13C	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: UNC13C

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.