Detail Information

Basic Information:


  VIRBase ID:  

HHID00058595

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:           FAM104A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-449a FAM104A
miRBase
Accession/Entrez ID		 MIMAT0001541 84923
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-449a
rs1294048688 chr5:55170588    C/A
rs749773363 chr5:55170591    C/G
rs780146909 chr5:55170586    A/G
rs913642990 chr5:55170597    A/G
rs987840066 chr5:55170596    A/G
rs755430105 chr5:55170602    C/G
rs779429211 chr5:55170603    T/G
rs933108375 chr5:55170605    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM104A
chr17:71226729(-) A-I      intronic
chr17:71226703(-) A-I      intronic
chr17:71220497(-) A-I      intronic
chr17:71220515(-) A-I      intronic
chr17:71220532(-) A-I      intronic
chr17:71222079(-) A-I      intronic
chr17:71220527(-) A-I      intronic
chr17:71222212(-) A-I      intronic
chr17:71222312(-) A-I      intronic
chr17:71222313(-) A-I      intronic
chr17:71225842(-) A-I      intronic
chr17:71225848(-) A-I      intronic
chr17:71225993(-) A-I      intronic
chr17:71226631(-) A-I      intronic
chr17:71226643(-) A-I      intronic
chr17:71226646(-) A-I      intronic
chr17:71226737(-) A-I      intronic
chr17:71226739(-) A-I      intronic
chr17:71226787(-) A-I      intronic
chr17:71211461(-) A-I      intronic
chr17:71211465(-) A-I      intronic
chr17:71211546(-) A-I      intronic
chr17:71213842(-) A-I      intronic
chr17:71214902(-) A-I      intronic
chr17:71214969(-) A-I      intronic
chr17:71215208(-) A-I      intronic
chr17:71215230(-) A-I      intronic
chr17:71215283(-) A-I      intronic
chr17:71215284(-) A-I      intronic
chr17:71215286(-) A-I      intronic
chr17:71215584(-) A-I      intronic
chr17:71215649(-) A-I      intronic
chr17:71215670(-) A-I      intronic
chr17:71215726(-) A-I      intronic
chr17:71216644(-) A-I      intronic
chr17:71216722(-) A-I      intronic
chr17:71216811(-) A-I      intronic
chr17:71216830(-) A-I      intronic
chr17:71217110(-) A-I      intronic
chr17:71217170(-) A-I      intronic
chr17:71217176(-) A-I      intronic
chr17:71217241(-) A-I      intronic
chr17:71220348(-) A-I      intronic
chr17:71206851(-) A-I      intronic
chr17:71219998(-) A-I      intronic
chr17:71226340(-) A-I      intronic
chr17:71226706(-) A-I      intronic
chr17:71226713(-) A-I      intronic
chr17:71218010(-) A-I      intronic
chr17:71225898(-) A-I      intronic
chr17:71216005(-) A-I      intronic
chr17:71226179(-) A-I      intronic
chr17:71226709(-) A-I      intronic
chr17:71216708(-) A-I      intronic
chr17:71218007(-) A-I      intronic
chr17:71216686(-) A-I      intronic
chr17:71222315(-) A-I      intronic
chr17:71222277(-) A-I      intronic
chr17:71213384(-) A-I      intronic
chr17:71216766(-) A-I      intronic
chr17:71226786(-) A-I      intronic
chr17:71213212(-) A-I      intronic
chr17:71206966(-) A-I      intronic
chr17:71216859(-) A-I      intronic
chr17:71211686(-) A-I      intronic
chr17:71220320(-) A-I      intronic
chr17:71226373(-) A-I      intronic
chr17:71214861(-) A-I      intronic
chr17:71211487(-) A-I      intronic
chr17:71206869(-) A-I      intronic
chr17:71226791(-) A-I      intronic
chr17:71225924(-) A-I      intronic
chr17:71218660(-) A-I      intronic
chr17:71225921(-) A-I      intronic
chr17:71226650(-) A-I      intronic
chr17:71215783(-) A-I      intronic
chr17:71222329(-) A-I      intronic
chr17:71216676(-) A-I      intronic
chr17:71220508(-) A-I      intronic
chr17:71208094(-) A-I      intronic
chr17:71206989(-) A-I      intronic
chr17:71211545(-) A-I      intronic
chr17:71226353(-) A-I      intronic
chr17:71208087(-) A-I      intronic
chr17:71226715(-) A-I      intronic
chr17:71222179(-) A-I      intronic
chr17:71216763(-) A-I      intronic
chr17:71220037(-) A-I      intronic
chr17:71217175(-) A-I      intronic
chr17:71207819(-) A-I      intronic
chr17:71214779(-) A-I      intronic
chr17:71213490(-) A-I      intronic
chr17:71226421(-) A-I      intronic
chr17:71226251(-) A-I      intronic
chr17:71219992(-) A-I      intronic
chr17:71206855(-) A-I      intronic
chr17:71211612(-) A-I      intronic
chr17:71226567(-) A-I      intronic
chr17:71224487(-) A-I      intronic
chr17:71222307(-) A-I      intronic
chr17:71211685(-) A-I      intronic
chr17:71215630(-) A-I      intronic
chr17:71206942(-) A-I      intronic
chr17:71222291(-) A-I      intronic
chr17:71226335(-) A-I      intronic
chr17:71213370(-) A-I      intronic
chr17:71206828(-) A-I      intronic
chr17:71206823(-) A-I      intronic
chr17:71226366(-) A-I      intronic
chr17:71226712(-) A-I      intronic
chr17:71213750(-) A-I      intronic
chr17:71206938(-) A-I      intronic
chr17:71218073(-) A-I      intronic
chr17:71207453(-) A-I      intronic
chr17:71211560(-) A-I      intronic
chr17:71222178(-) A-I      intronic
chr17:71222210(-) A-I      intronic
chr17:71222133(-) A-I      intronic
chr17:71226651(-) A-I      intronic
chr17:71225748(-) A-I      intronic
chr17:71215677(-) A-I      intronic
chr17:71220476(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FAM104A
chr17:71226709(-) A-I intron -    22327324
chr17:71206869(-) A-G intron -    22484847
chr17:71206942(-) A-G intron -    22484847
chr17:71211612(-) A-G intron -    22484847
chr17:71225921(-) A-G intron -    22484847
chr17:71226650(-) A-G intron -    22484847
chr17:71226651(-) A-G intron -    22484847
chr17:71226706(-) A-G intron -    22484847
chr17:71226709(-) A-G intron -    22484847
chr17:71226715(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM104A
chr17:71203549-71203550(-) m6A 3'UTR       27773535
chr17:71203713-71203714(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203728-71203729(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203733-71203734(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203748-71203749(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203792-71203793(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203804-71203805(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203909-71203910(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203930-71203931(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203951-71203952(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204070-71204071(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204107-71204108(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204147-71204148(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204170-71204171(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204215-71204216(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204236-71204237(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204256-71204257(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204279-71204280(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204286-71204287(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204315-71204316(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204456-71204457(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204492-71204493(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:71204506-71204507(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr17:71204606-71204607(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085
chr17:71204690-71204691(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr17:71204757-71204758(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204795-71204796(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204896-71204897(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr17:71204949-71204950(-) m6A 3'UTR       24284625//24981863//22608085
chr17:71204962-71204963(-) m6A 3'UTR       24284625//24981863//22608085
chr17:71205333-71205334(-) m6A 3'UTR       27773535
chr17:71205360-71205361(-) m6A 3'UTR       27773535
chr17:71205400-71205401(-) m6A 3'UTR       27773535
chr17:71205634-71205635(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22608085
chr17:71205723-71205724(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//27773536
chr17:71205810-71205811(-) m6A 3'UTR//CDS//exon       24284625//27371828//27773536
chr17:71205845-71205846(-) m6A CDS//exon       24284625//27371828//27773536
chr17:71208832-71208833(-) m6A CDS//intron       24284625
chr17:71208843-71208844(-) m6A CDS//intron       24284625
chr17:71208847-71208848(-) m6A CDS//intron       24284625
chr17:71208859-71208860(-) m6A CDS//intron       24284625
chr17:71223310-71223311(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223334-71223335(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223353-71223354(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223373-71223374(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223376-71223377(-) m1A 5'UTR//CDS//exon//intron       26863196
chr17:71228311-71228312(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536
chr17:71232810-71232811(-) m6A exon       24284625//24981863
chr17:71232838-71232839(-) m6A exon       24284625//24981863
chr17:71232881-71232882(-) m6A exon       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-449a
Exosome Serum     18589210
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
FAM104A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-449a
Interactor2: FAM104A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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