Detail Information

Basic Information:


  VIRBase ID:  

HHID00058594

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:           ZNF644:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-449a ZNF644
miRBase
Accession/Entrez ID		 MIMAT0001541 84146
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BM-005//MYP21//NatF//ZEP-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-449a
rs1294048688 chr5:55170588    C/A
rs749773363 chr5:55170591    C/G
rs780146909 chr5:55170586    A/G
rs913642990 chr5:55170597    A/G
rs987840066 chr5:55170596    A/G
rs755430105 chr5:55170602    C/G
rs779429211 chr5:55170603    T/G
rs933108375 chr5:55170605    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF644
chr1:91394152(-) A-I      intronic
chr1:91394147(-) A-I      intronic
chr1:91439803(-) A-I      intronic
chr1:91455366(-) A-I      intronic
chr1:91431435(-) A-I      intronic
chr1:91431412(-) A-I      intronic
chr1:91478008(-) A-I      intronic
chr1:91477978(-) A-I      intronic
chr1:91477973(-) A-I      intronic
chr1:91477935(-) A-I      intronic
chr1:91477916(-) A-I      intronic
chr1:91477905(-) A-I      intronic
chr1:91475978(-) A-I      intronic
chr1:91475976(-) A-I      intronic
chr1:91475970(-) A-I      intronic
chr1:91475969(-) A-I      intronic
chr1:91475955(-) A-I      intronic
chr1:91431484(-) A-I      intronic
chr1:91439840(-) A-I      intronic
chr1:91439810(-) A-I      intronic
chr1:91439809(-) A-I      intronic
chr1:91439804(-) A-I      intronic
chr1:91431478(-) A-I      intronic
chr1:91431439(-) A-I      intronic
chr1:91431437(-) A-I      intronic
chr1:91393778(-) A-I      intronic
chr1:91393834(-) A-I      intronic
chr1:91394012(-) A-I      intronic
chr1:91394013(-) A-I      intronic
chr1:91399138(-) A-I      intronic
chr1:91399164(-) A-I      intronic
chr1:91399183(-) A-I      intronic
chr1:91399241(-) A-I      intronic
chr1:91400562(-) A-I      intronic
chr1:91419280(-) A-I      intronic
chr1:91419365(-) A-I      intronic
chr1:91419373(-) A-I      intronic
chr1:91420176(-) A-I      intronic
chr1:91420236(-) A-I      intronic
chr1:91431418(-) A-I      intronic
chr1:91431444(-) A-I      intronic
chr1:91431445(-) A-I      intronic
chr1:91432150(-) A-I      intronic
chr1:91432158(-) A-I      intronic
chr1:91478693(-) A-I      intronic
chr1:91477966(-) A-I      intronic
chr1:91462238(-) A-I      intronic
chr1:91443706(-) A-I      intronic
chr1:91420182(-) A-I      intronic
chr1:91462098(-) A-I      intronic
chr1:91449362(-) A-I      intronic
chr1:91443705(-) A-I      intronic
chr1:91443674(-) A-I      intronic
chr1:91441132(-) A-I      intronic
chr1:91441087(-) A-I      intronic
chr1:91441067(-) A-I      intronic
chr1:91439867(-) A-I      intronic
chr1:91437595(-) A-I      intronic
chr1:91437590(-) A-I      intronic
chr1:91431471(-) A-I      intronic
chr1:91437584(-) A-I      intronic
chr1:91437246(-) A-I      intronic
chr1:91437204(-) A-I      intronic
chr1:91437128(-) A-I      intronic
chr1:91437109(-) A-I      intronic
chr1:91436445(-) A-I      intronic
chr1:91436435(-) A-I      intronic
chr1:91436400(-) A-I      intronic
chr1:91436391(-) A-I      intronic
chr1:91436385(-) A-I      intronic
chr1:91478799(-) A-I      intronic
chr1:91432225(-) A-I      intronic
chr1:91432167(-) A-I      intronic
chr1:91432159(-) A-I      intronic
chr1:91420183(-) A-I      intronic
chr1:91478736(-) A-I      intronic
chr1:91485350(-) A-I      intronic
chr1:91485224(-) A-I      intronic
chr1:91485213(-) A-I      intronic
chr1:91485140(-) A-I      intronic
chr1:91483407(-) A-I      intronic
chr1:91483274(-) A-I      intronic
chr1:91482669(-) A-I      intronic
chr1:91482663(-) A-I      intronic
chr1:91482617(-) A-I      intronic
chr1:91482554(-) A-I      intronic
chr1:91482518(-) A-I      intronic
chr1:91482492(-) A-I      intronic
chr1:91478703(-) A-I      intronic
chr1:91432198(-) A-I      intronic
chr1:91478727(-) A-I      intronic
chr1:91432063(-) A-I      intronic
chr1:91431481(-) A-I      intronic
chr1:91475968(-) A-I      intronic
chr1:91475977(-) A-I      intronic
chr1:91477952(-) A-I      intronic
chr1:91432152(-) A-I      intronic
chr1:91431369(-) A-I      intronic
chr1:91420088(-) A-I      intronic
chr1:91431486(-) A-I      intronic
chr1:91471846(-) A-I      intronic
chr1:91483419(-) A-I      intronic
chr1:91383248(-) A-I      intronic
chr1:91478769(-) A-I      intronic
chr1:91472889(-) A-I      intronic
chr1:91420215(-) A-I      intronic
chr1:91420191(-) A-I      intronic
chr1:91419466(-) A-I      intronic
chr1:91478768(-) A-I      intronic
chr1:91432135(-) A-I      intronic
chr1:91477913(-) A-I      intronic
chr1:91437114(-) A-I      intronic
chr1:91431088(-) A-I      intronic
chr1:91475933(-) A-I      intronic
chr1:91437085(-) A-I      intronic
chr1:91431334(-) A-I      intronic
chr1:91432090(-) A-I      intronic
chr1:91451368(-) A-I      intronic
chr1:91449904(-) A-I      intronic
chr1:91420252(-) A-I      intronic
chr1:91478729(-) A-I      intronic
chr1:91437155(-) A-I      intronic
chr1:91394083(-) A-I      intronic
chr1:91450437(-) A-I      intronic
chr1:91432224(-) A-I      intronic
chr1:91431421(-) A-I      intronic
chr1:91455439(-) A-I      intronic
chr1:91436394(-) A-I      intronic
chr1:91478771(-) A-I      intronic
chr1:91478699(-) A-I      intronic
chr1:91437190(-) A-I      intronic
chr1:91455440(-) A-I      intronic
chr1:91449477(-) A-I      intronic
chr1:91419468(-) A-I      intronic
chr1:91478013(-) A-I      intronic
chr1:91437594(-) A-I      intronic
chr1:91439734(-) A-I      intronic
chr1:91394159(-) A-I      intronic
chr1:91478728(-) A-I      intronic
chr1:91439749(-) A-I      intronic
chr1:91441002(-) A-I      intronic
chr1:91474530(-) A-I      intronic
chr1:91394126(-) A-I      intronic
chr1:91437101(-) A-I      intronic
chr1:91420143(-) A-I      intronic
chr1:91441143(-) A-I      intronic
chr1:91462172(-) A-I      intronic
chr1:91483362(-) A-I      intronic
chr1:91439775(-) A-I      intronic
chr1:91478698(-) A-I      intronic
chr1:91476073(-) A-I      intronic
chr1:91475881(-) A-I      intronic
chr1:91437040(-) A-I      intronic
chr1:91432103(-) A-I      intronic
chr1:91436510(-) A-I      intronic
chr1:91478798(-) A-I      intronic
chr1:91420214(-) A-I      intronic
chr1:91449884(-) A-I      intronic
chr1:91482423(-) A-I      intronic
chr1:91477953(-) A-I      intronic
chr1:91485230(-) A-I      intronic
chr1:91432185(-) A-I      intronic
chr1:91437165(-) A-I      intronic
chr1:91419237(-) A-I      intronic
chr1:91437159(-) A-I      intronic
chr1:91471964(-) A-I      intronic
chr1:91420142(-) A-I      intronic
chr1:91393999(-) A-I      intronic
chr1:91437185(-) A-I      intronic
chr1:91478804(-) A-I      intronic
chr1:91485243(-) A-I      intronic
chr1:91420210(-) A-I      intronic
chr1:91420060(-) A-I      intronic
chr1:91449881(-) A-I      intronic
chr1:91436985(-) A-I      intronic
chr1:91441179(-) A-I      intronic
chr1:91455375(-) A-I      intronic
chr1:91431090(-) A-I      intronic
chr1:91431583(-) A-I      intronic
chr1:91432062(-) A-I      intronic
chr1:91393525(-) A-I      intronic
chr1:91451470(-) A-I      intronic
chr1:91477911(-) A-I      intronic
chr1:91439802(-) A-I      intronic
chr1:91485299(-) A-I      intronic
chr1:91450418(-) A-I      intronic
chr1:91436519(-) A-I      intronic
chr1:91437105(-) A-I      intronic
chr1:91395804(-) A-I      intronic
chr1:91485268(-) A-I      intronic
chr1:91477959(-) A-I      intronic
chr1:91436474(-) A-I      intronic
chr1:91471927(-) A-I      intronic
chr1:91439839(-) A-I      intronic
chr1:91477983(-) A-I      intronic
chr1:91436457(-) A-I      intronic
chr1:91478704(-) A-I      intronic
chr1:91483356(-) A-I      intronic
chr1:91432207(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF644
chr1:91419237(-) A-I intron -    15258596
chr1:91419468(-) A-I intron -    15258596
chr1:91420060(-) A-I intron -    15258596
chr1:91420088(-) A-I intron -    15258596
chr1:91420215(-) A-I intron -    15258596
chr1:91436394(-) A-I intron -    22327324
chr1:91455375(-) A-I intron -    21960545
chr1:91431088(-) A-G intron -    22484847
chr1:91431090(-) A-G intron -    22484847
chr1:91449904(-) A-G intron -    22484847
chr1:91450418(-) A-G intron -    22484847
chr1:91455440(-) A-G intron -    22484847
chr1:91393525(-) A-G intron -    22484847
chr1:91393999(-) A-G intron -    22484847
chr1:91394159(-) A-G intron -    22484847
chr1:91419466(-) A-G intron -    22484847
chr1:91419468(-) A-G intron -    22484847
chr1:91420142(-) A-G intron -    22484847
chr1:91420143(-) A-G intron -    22484847
chr1:91420191(-) A-G intron -    22484847
chr1:91420210(-) A-G intron -    22484847
chr1:91420252(-) A-G intron -    22484847
chr1:91431334(-) A-G intron -    22484847
chr1:91431421(-) A-G intron -    22484847
chr1:91431481(-) A-G intron -    22484847
chr1:91431486(-) A-G intron -    22484847
chr1:91432062(-) A-G intron -    22484847
chr1:91432090(-) A-G intron -    22484847
chr1:91432103(-) A-G intron -    22484847
chr1:91432135(-) A-G intron -    22484847
chr1:91432152(-) A-G intron -    22484847
chr1:91432185(-) A-G intron -    22484847
chr1:91432198(-) A-G intron -    22484847
chr1:91432207(-) A-G intron -    22484847
chr1:91433379(-) A-T intron -    22484847
chr1:91433449(-) A-T intron -    22484847
chr1:91433450(-) T-A intron -    22484847
chr1:91433451(-) G-T intron -    22484847
chr1:91436394(-) A-G intron -    22484847
chr1:91436457(-) A-G intron -    22484847
chr1:91436474(-) A-G intron -    22484847
chr1:91436481(-) G-A intron -    22484847
chr1:91436519(-) A-G intron -    22484847
chr1:91436985(-) A-G intron -    22484847
chr1:91437040(-) A-G intron -    22484847
chr1:91437101(-) A-G intron -    22484847
chr1:91437114(-) A-G intron -    22484847
chr1:91437159(-) A-G intron -    22484847
chr1:91437165(-) A-G intron -    22484847
chr1:91437169(-) T-C intron -    22484847
chr1:91437185(-) A-G intron -    22484847
chr1:91439749(-) A-G intron -    22484847
chr1:91439887(-) T-G intron -    22484847
chr1:91444789(-) T-C intron -    22484847
chr1:91477959(-) A-G intron -    22484847
chr1:91477983(-) A-G intron -    22484847
chr1:91478704(-) A-G intron -    22484847
chr1:91478727(-) A-G intron -    22484847
chr1:91478728(-) A-G intron -    22484847
chr1:91478729(-) A-G intron -    22484847
chr1:91478768(-) A-G intron -    22484847
chr1:91478769(-) A-G intron -    22484847
chr1:91478771(-) A-G intron -    22484847
chr1:91478798(-) A-G intron -    22484847
chr1:91485153(-) A-C intron -    22484847
chr1:91485168(-) T-G intron -    22484847
chr1:91485230(-) A-G intron -    22484847
chr1:91485268(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF644
chr1:91381984-91381985(-) m6A 3'UTR//exon       24981863//26404942
chr1:91382040-91382041(-) m6A 3'UTR//exon       24981863//26404942
chr1:91382053-91382054(-) m6A 3'UTR//exon       24981863//26404942
chr1:91382077-91382078(-) m6A 3'UTR//exon       24981863//26404942
chr1:91382344-91382345(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr1:91382352-91382353(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr1:91382392-91382393(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr1:91382452-91382453(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr1:91382502-91382503(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr1:91382522-91382523(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr1:91401066-91401067(-) m6A exon//intron       27773535//22608085
chr1:91403058-91403059(-) m6A CDS//intron       27773535//22608085
chr1:91403140-91403141(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr1:91403210-91403211(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91403252-91403253(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403258-91403259(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403263-91403264(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403329-91403330(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403399-91403400(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403417-91403418(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403439-91403440(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403540-91403541(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr1:91403618-91403619(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91403629-91403630(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91403852-91403853(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91403864-91403865(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91403904-91403905(-) m6A CDS//intron       24284625//27773535//22608085
chr1:91403990-91403991(-) m6A CDS//intron       24284625//27773535//22608085
chr1:91404044-91404045(-) m6A CDS//intron       24284625//27773535//22608085
chr1:91404089-91404090(-) m6A CDS//intron       24284625//22608085
chr1:91404278-91404279(-) m6A CDS//intron       27773535//22608085
chr1:91404307-91404308(-) m6A CDS//intron       27773535//22608085
chr1:91404347-91404348(-) m6A CDS//intron       27773535//22608085
chr1:91404381-91404382(-) m6A CDS//intron       27773535//22608085
chr1:91404436-91404437(-) m6A CDS//intron       27773535//22608085
chr1:91404547-91404548(-) m6A CDS//intron       27773535//22608085
chr1:91404673-91404674(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91404687-91404688(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91404756-91404757(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91404805-91404806(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91404820-91404821(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91404853-91404854(-) Am CDS//intron       -
chr1:91404920-91404921(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91404936-91404937(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91404949-91404950(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91404975-91404976(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91404986-91404987(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr1:91405011-91405012(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91405044-91405045(-) m6A CDS//intron       24209618//24981863//27773535//22608085
chr1:91405189-91405190(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//22608085
chr1:91405202-91405203(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//22608085
chr1:91405214-91405215(-) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//27371828//22608085
chr1:91405361-91405362(-) m6A CDS//intron       24284625//24981863//22608085
chr1:91405382-91405383(-) m6A CDS//intron       24981863//22608085
chr1:91405452-91405453(-) m6A CDS//intron       24981863//26404942//22608085
chr1:91405488-91405489(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr1:91405515-91405516(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr1:91405544-91405545(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr1:91405852-91405853(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91405903-91405904(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91405929-91405930(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91405939-91405940(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91406087-91406088(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91406137-91406138(-) m6A CDS//intron       24981863//27773535//22608085
chr1:91406331-91406332(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr1:91406487-91406488(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406528-91406529(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406556-91406557(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406590-91406591(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406668-91406669(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406679-91406680(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406720-91406721(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:91406758-91406759(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085
chr1:91406787-91406788(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085
chr1:91406815-91406816(-) m6A CDS//exon//intron       22608085
chr1:91486132-91486133(-) m6A exon//intron       27773535
chr1:91486177-91486178(-) m6A exon//intron       27773535
chr1:91486220-91486221(-) m6A exon//intron       27773535
chr1:91486247-91486248(-) m6A exon//intron       27773535
chr1:91486263-91486264(-) m6A exon//intron       27773535
chr1:91486290-91486291(-) m6A exon//intron       27773535
chr1:91486457-91486458(-) m6A exon//intron       27773535//22608085
chr1:91486474-91486475(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr1:91486499-91486500(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr1:91486592-91486593(-) m6A exon//intron       24981863//27773535//22608085
chr1:91486602-91486603(-) m6A exon//intron       24981863//27773535//22608085
chr1:91486638-91486639(-) m6A exon//intron       24981863//27773535//22608085
chr1:91486658-91486659(-) m6A exon//intron       27773535//22608085
chr1:91486680-91486681(-) m6A exon//intron       27773535
chr1:91487548-91487549(-) m6A 5'UTR//exon       27773536
chr1:91487677-91487678(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-449a
Exosome Serum     18589210
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
ZNF644
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-449a
Interactor2: ZNF644

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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