Detail Information

Basic Information:


  VIRBase ID:  

HHID00058588

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:           TRMT5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-449a TRMT5
miRBase
Accession/Entrez ID		 MIMAT0001541 57570
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - COXPD26//KIAA1393//TRM5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-449a
rs1294048688 chr5:55170588    C/A
rs749773363 chr5:55170591    C/G
rs780146909 chr5:55170586    A/G
rs913642990 chr5:55170597    A/G
rs987840066 chr5:55170596    A/G
rs755430105 chr5:55170602    C/G
rs779429211 chr5:55170603    T/G
rs933108375 chr5:55170605    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRMT5
chr14:61438324-61438325(-) m6A 3'UTR       27773535
chr14:61438353-61438354(-) m6A 3'UTR       27773535
chr14:61438387-61438388(-) m6A 3'UTR       27773535
chr14:61438568-61438569(-) m6A 3'UTR       24981863//22608085
chr14:61438580-61438581(-) m6A 3'UTR       24981863//22608085
chr14:61438601-61438602(-) m6A 3'UTR       24981863//22608085
chr14:61438649-61438650(-) m6A 3'UTR       24981863
chr14:61439091-61439092(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr14:61439168-61439169(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr14:61439252-61439253(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085
chr14:61439380-61439381(-) m6A 3'UTR       27773535
chr14:61439393-61439394(-) m6A 3'UTR       27773535
chr14:61440725-61440726(-) m6A 3'UTR       24981863
chr14:61442204-61442205(-) m6A CDS       27773535
chr14:61442209-61442210(-) m6A CDS       27773535
chr14:61442263-61442264(-) m6A CDS       27773535
chr14:61442476-61442477(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr14:61442499-61442500(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr14:61442550-61442551(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr14:61442563-61442564(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr14:61442599-61442600(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr14:61442677-61442678(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61442745-61442746(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61442754-61442755(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61442772-61442773(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61442833-61442834(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61444244-61444245(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61445958-61445959(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61445986-61445987(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr14:61446003-61446004(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr14:61446081-61446082(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr14:61446093-61446094(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr14:61446150-61446151(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:61446207-61446208(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr14:61446338-61446339(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446353-61446354(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446363-61446364(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446407-61446408(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446422-61446423(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446428-61446429(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr14:61446509-61446510(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61446561-61446562(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:61447587-61447588(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr14:61447789-61447790(-) m6A 5'UTR//CDS       25456834//24981863//27773536
chr14:61447810-61447811(-) m6A 5'UTR//CDS       25456834//24981863//27773536
chr14:61448041-61448042(-) m6A 5'UTR       24981863
chr14:61448047-61448048(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-449a
Exosome Serum     18589210
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
TRMT5
Exosome Blood     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-449a
Interactor2: TRMT5

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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