Basic Information:

  VIRBase ID:  

HHID00058586

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          RAB5IF:  NM_001374178     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	RAB5IF
miRBase Accession/Entrez ID	MIMAT0001541	55969
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf24//PNAS-11//RCAF1//RIP5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB5IF	chr20:35239593(+) A-I      intronic chr20:35237084(+) A-I      intronic chr20:35239448(+) A-I      intronic chr20:35236717(+) A-I      intronic chr20:35239602(+) A-I      intronic chr20:35239623(+) A-I      intronic chr20:35238509(+) A-I      intronic chr20:35238550(+) A-I      intronic chr20:35238880(+) A-I      intronic chr20:35239654(+) A-I      intronic chr20:35239580(+) A-I      intronic chr20:35239567(+) A-I      intronic chr20:35239492(+) A-I      intronic chr20:35239085(+) A-I      intronic chr20:35238983(+) A-I      intronic chr20:35236838(+) A-I      intronic chr20:35239522(+) A-I      intronic chr20:35237746(+) A-I      intronic chr20:35239039(+) A-I      intronic chr20:35238977(+) A-I      intronic chr20:35238572(+) A-I      intronic chr20:35239510(+) A-I      intronic chr20:35239659(+) A-I      intronic chr20:35238850(+) A-I      intronic chr20:35239576(+) A-I      intronic chr20:35239775(+) A-I      intronic chr20:35238987(+) A-I      intronic chr20:35238608(+) A-I      intronic chr20:35237053(+) A-I      intronic chr20:35237808(+) A-I      intronic chr20:35239532(+) A-I      intronic chr20:35239573(+) A-I      intronic chr20:35238567(+) A-I      intronic chr20:35236789(+) A-I      intronic chr20:35239744(+) A-I      intronic chr20:35239656(+) A-I      intronic chr20:35238566(+) A-I      intronic chr20:35238471(+) A-I      intronic chr20:35239745(+) A-I      intronic chr20:35239493(+) A-I      intronic chr20:35239628(+) A-I      intronic chr20:35239851(+) A-I      intronic chr20:35239534(+) A-I      intronic chr20:35238431(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	RAB5IF	Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: RAB5IF

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.