Basic Information:

  VIRBase ID:  

HHID00058583

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          SLC25A39:  NR_159404     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	SLC25A39
miRBase Accession/Entrez ID	MIMAT0001541	51629
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-69//CGI69

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC25A39	chr17:42400419(-) A-I      intronic chr17:42400388(-) A-I      intronic chr17:42400412(-) A-I      intronic chr17:42399517(-) A-I      intronic chr17:42400484(-) A-I      intronic chr17:42400509(-) A-I      intronic chr17:42399509(-) A-I      intronic chr17:42399535(-) A-I      intronic chr17:42401148(-) A-I      intronic chr17:42401081(-) A-I      intronic chr17:42399615(-) A-I      intronic chr17:42401138(-) A-I      intronic chr17:42399357(-) A-I      intronic chr17:42401174(-) A-I      intronic chr17:42399492(-) A-I      intronic chr17:42399505(-) A-I      intronic chr17:42399400(-) A-I      intronic chr17:42401120(-) A-I      intronic chr17:42400563(-) A-I      intronic chr17:42400380(-) A-I      intronic chr17:42400473(-) A-I      intronic chr17:42399451(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC25A39	chr17:42396999-42397000(-) m6A 3'UTR//exon       24284625//27773535 chr17:42397067-42397068(-) m6A 3'UTR//exon       24284625//27773535 chr17:42397133-42397134(-) m6A 3'UTR//exon       24284625//27773535//22575960 chr17:42397196-42397197(-) m6A 3'UTR//exon       24284625//27773535//22575960 chr17:42397309-42397310(-) m6A 3'UTR//exon       24284625//25456834//26404942//27773535//27773536//22575960 chr17:42397348-42397349(-) m6A 3'UTR//exon       24284625//25456834//26404942//27773536//22575960 chr17:42397387-42397388(-) m6A 3'UTR//CDS//exon       24284625//25456834//26404942//27773536//22575960 chr17:42397393-42397394(-) m6A 3'UTR//CDS//exon       24284625//25456834//26404942//27773536//22575960 chr17:42397573-42397574(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960 chr17:42397625-42397626(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960 chr17:42397640-42397641(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960 chr17:42397693-42397694(-) m6A exon//intron       27773535//22575960 chr17:42397764-42397765(-) m6A 3'UTR//CDS//exon       22575960 chr17:42398033-42398034(-) m6A 3'UTR//CDS//exon       22575960 chr17:42398038-42398039(-) m6A 3'UTR//CDS//exon       22575960 chr17:42398503-42398504(-) m6A CDS//exon//intron       24284625//22575960 chr17:42398557-42398558(-) m6A CDS//exon//intron       24284625//22575960 chr17:42398645-42398646(-) m6A exon//intron       24284625//22575960 chr17:42398671-42398672(-) m6A 3'UTR//exon//intron       24284625 chr17:42398678-42398679(-) m6A 3'UTR//exon//intron       24284625 chr17:42398749-42398750(-) m6A CDS//exon//intron       24284625 chr17:42399095-42399096(-) m6A 5'UTR//CDS//exon       24284625//27773535//22575960 chr17:42400916-42400917(-) m6A CDS//exon//intron       24284625//27773536//22575960 chr17:42400943-42400944(-) m6A 5'UTR//exon//intron       24284625//27773536//22575960 chr17:42401020-42401021(-) m6A 5'UTR//exon//intron       27773536 chr17:42401398-42401399(-) m6A exon//intron       22575960 chr17:42401471-42401472(-) m6A exon//intron       24209618//25456834//22575960 chr17:42401526-42401527(-) m6A 5'UTR//intron       24284625//24209618//25456834//22575960 chr17:42401552-42401553(-) m6A 5'UTR//intron       24284625//25456834//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	SLC25A39	Chromatin K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: SLC25A39

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.