Basic Information:

  VIRBase ID:  

HHID00058570

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          AP1G2:  NR_148937     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	AP1G2
miRBase Accession/Entrez ID	MIMAT0001541	8906
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	G2AD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AP1G2	chr14:24029839(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AP1G2	chr14:24028832-24028833(-) m6A 3'UTR//exon       24284625//27773535 chr14:24028839-24028840(-) m6A 3'UTR//exon       24284625//27773535 chr14:24028891-24028892(-) m6A 3'UTR//exon       24284625//27773535 chr14:24028917-24028918(-) m6A 3'UTR//exon       24284625//27773535 chr14:24028985-24028986(-) m6A CDS//exon       27773535 chr14:24029210-24029211(-) m6A CDS//exon       27773535 chr14:24029258-24029259(-) m6A exon//intron       27773535 chr14:24029551-24029552(-) m6A CDS//exon       27773535 chr14:24031502-24031503(-) m6A CDS//exon       - chr14:24032817-24032818(-) m6A CDS//exon       27773535//27371828 chr14:24034494-24034495(-) m6A exon//intron       27773535 chr14:24034541-24034542(-) m6A exon//intron       27773535 chr14:24034549-24034550(-) m6A exon//intron       27773535 chr14:24034850-24034851(-) m6A 3'UTR//CDS//exon       - chr14:24034879-24034880(-) m6A 3'UTR//CDS//exon       - chr14:24034987-24034988(-) m6A exon//intron       27371828//27773536 chr14:24035150-24035151(-) m6A exon//intron       24284625//24981863//27773535//27371828//27773536 chr14:24035203-24035204(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr14:24035229-24035230(-) m6A exon//intron       24284625//24981863//27773535 chr14:24035327-24035328(-) m6A 3'UTR//CDS//exon       27773535 chr14:24035854-24035855(-) m6A CDS//exon//intron       27371828 chr14:24035880-24035881(-) m6A CDS//exon//intron       27371828 chr14:24036142-24036143(-) m6A exon//intron       24981863 chr14:24036187-24036188(-) m6A exon//intron       - chr14:24036322-24036323(-) m6A CDS//exon//intron       27371828//27773536 chr14:24036364-24036365(-) m6A CDS//exon//intron       27371828//27773536 chr14:24036395-24036396(-) m6A CDS//exon//intron       27371828//27773536 chr14:24036465-24036466(-) m6A CDS//exon       25456834//24981863//27371828//27773536 chr14:24036494-24036495(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536 chr14:24036537-24036538(-) m6A 5'UTR//exon//intron       25456834//24981863//27773535//27371828//27773536 chr14:24036859-24036860(-) m6A 5'UTR//intron       24981863//27371828 chr14:24037028-24037029(-) m6A 5'UTR//exon       24981863 chr14:24037150-24037151(-) m6A 5'UTR       24981863 chr14:24037198-24037199(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	AP1G2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: AP1G2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.