Basic Information:

  VIRBase ID:  

HHID00058549

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          GMFB:  NM_004124     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	GMFB
miRBase Accession/Entrez ID	MIMAT0001541	2764
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GMF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GMFB	chr14:54954141(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GMFB	chr14:54942712-54942713(-) m6A 3'UTR       27773535 chr14:54944747-54944748(-) m6A 3'UTR//exon       27773535 chr14:54944799-54944800(-) m6A 3'UTR//exon       27773535 chr14:54944823-54944824(-) m6A 3'UTR//CDS//exon       27773535 chr14:54944851-54944852(-) m6A 3'UTR//CDS//exon       27773535 chr14:54946512-54946513(-) m6A 3'UTR//CDS//exon       27773535 chr14:54946520-54946521(-) m6A 3'UTR//CDS//exon       27773535 chr14:54946563-54946564(-) m6A 3'UTR//CDS//exon       27773535 chr14:54950405-54950406(-) m6A CDS//exon       24209618//24981863//27773535 chr14:54950684-54950685(-) m6A CDS//intron       24209618//24981863 chr14:54950736-54950737(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	GMFB	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: GMFB

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.