Basic Information:

  VIRBase ID:  

HHID00058545

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:  MIMAT0001541          CR2:  NM_001006658     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-449a	CR2
miRBase Accession/Entrez ID	MIMAT0001541	1380
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C3DR//CD21//CR//CVID7//SLEB9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-449a	rs1294048688 chr5:55170588    C/A rs749773363 chr5:55170591    C/G rs780146909 chr5:55170586    A/G rs913642990 chr5:55170597    A/G rs987840066 chr5:55170596    A/G rs755430105 chr5:55170602    C/G rs779429211 chr5:55170603    T/G rs933108375 chr5:55170605    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CR2	chr1:207659488(+) A-I      intronic chr1:207652389(+) A-I      intronic chr1:207660732(+) A-I      intronic chr1:207659501(+) A-I      intronic chr1:207660663(+) A-I      intronic chr1:207645323(+) A-I      intronic chr1:207651639(+) A-I      intronic chr1:207652352(+) A-I      intronic chr1:207660731(+) A-I      intronic chr1:207652416(+) A-I      intronic chr1:207652430(+) A-I      intronic chr1:207652431(+) A-I      intronic chr1:207660736(+) A-I      intronic chr1:207652429(+) A-I      intronic chr1:207651629(+) A-I      intronic chr1:207659525(+) A-I      intronic chr1:207659496(+) A-I      intronic chr1:207660701(+) A-I      intronic chr1:207651779(+) A-I      intronic chr1:207651591(+) A-I      intronic chr1:207651666(+) A-I      intronic chr1:207651669(+) A-I      intronic chr1:207652359(+) A-I      intronic chr1:207659526(+) A-I      intronic chr1:207660682(+) A-I      intronic chr1:207660711(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CR2	chr1:207651666(+) A-I intron -    22327324 chr1:207652359(+) A-I intron -    22327324 chr1:207660711(+) A-I intron -    22327324 chr1:207651591(+) A-G intron -    22484847 chr1:207651639(+) A-G intron -    22484847 chr1:207651666(+) A-G intron -    22484847 chr1:207651669(+) A-G intron -    22484847 chr1:207652359(+) A-G intron -    22484847 chr1:207652389(+) A-G intron -    22484847 chr1:207652416(+) A-G intron -    22484847 chr1:207652429(+) A-G intron -    22484847 chr1:207652430(+) A-G intron -    22484847 chr1:207652431(+) A-G intron -    22484847 chr1:207659496(+) A-G intron -    22484847 chr1:207659501(+) A-G intron -    22484847 chr1:207659525(+) A-G intron -    22484847 chr1:207660701(+) A-G intron -    22484847 chr1:207660711(+) A-G intron -    22484847 chr1:207660731(+) A-G intron -    22484847 chr1:207660732(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CR2	chr1:207648231-207648232(+) m6A CDS       - chr1:207648325-207648326(+) m6A CDS       - chr1:207648403-207648404(+) m6A CDS       - chr1:207648425-207648426(+) m6A CDS       - chr1:207662628-207662629(+) m6A 3'UTR       - chr1:207662682-207662683(+) m6A 3'UTR       - chr1:207662733-207662734(+) m6A 3'UTR       - chr1:207662804-207662805(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-449a	Exosome Serum     18589210 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	CR2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-449a
Interactor2: CR2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.