Detail Information

Basic Information:


  VIRBase ID:  

HHID00057837

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-425-3p:           MBNL3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-425-3p MBNL3
miRBase
Accession/Entrez ID		 MIMAT0001343 55796
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CHCR//MBLX//MBLX39//MBXL

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-425-3p
rs1180702190 chr3:49020166    CACG/C
rs538769454 chr3:49020168    C/G
rs538769454 chr3:49020168    C/T
rs759535995 chr3:49020162    C/T
rs771779613 chr3:49020163    G/C
rs774483175 chr3:49020161    G/A
rs374899781 chr3:49020177    C/G
rs374899781 chr3:49020177    C/T
rs759930741 chr3:49020145    GCCGAAAGAGCACTGGGCGGACACGACATTC/G

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MBNL3
chrX:131568981(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MBNL3
chrX:131503521-131503522(-) m6A 3'UTR       27773535//22608085
chrX:131503527-131503528(-) m6A 3'UTR       27773535//22575960//22608085
chrX:131503611-131503612(-) m6A 3'UTR       27773535//22575960//22608085
chrX:131503666-131503667(-) m6A 3'UTR       27773535//22608085
chrX:131503671-131503672(-) m6A 3'UTR       27773535//22608085
chrX:131503689-131503690(-) m6A 3'UTR       27773535//22608085
chrX:131503842-131503843(-) m6A 3'UTR       27773535
chrX:131503848-131503849(-) m6A 3'UTR       27773535
chrX:131503893-131503894(-) m6A 3'UTR       27773535
chrX:131507461-131507462(-) m6A 3'UTR       27773535
chrX:131513561-131513562(-) m6A 3'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-425-3p
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MBNL3
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-425-3p
Sorafenib 216239       25040368

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-425-3p
Interactor2: MBNL3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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