Basic Information:

  VIRBase ID:  

HHID00057432

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-335-5p:  MIMAT0000765          TMEM170B:  NM_001100829     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-335-5p	TMEM170B
miRBase Accession/Entrez ID	MIMAT0000765	100113407
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-335-5p	rs1302490829 chr7:130496145    A/G rs1377015261 chr7:130496142    A/G rs1393189017 chr7:130496140    G/A rs1448957394 chr7:130496147    G/GT rs1554436905 chr7:130496134    A/G rs1554436906 chr7:130496137    A/G rs371790774 chr7:130496139    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM170B	chr6:11549623(+) A-I      intronic chr6:11546053(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM170B	chr6:11538598-11538599(+) m6A CDS       24284625 chr6:11575702-11575703(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:11575739-11575740(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:11575829-11575830(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr6:11575896-11575897(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr6:11575922-11575923(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:11576019-11576020(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:11578673-11578674(+) m6A 3'UTR       24981863//22608085 chr6:11578688-11578689(+) m6A 3'UTR       24981863//22608085 chr6:11578741-11578742(+) m6A 3'UTR       24981863//22608085 chr6:11578760-11578761(+) m6A 3'UTR       22608085 chr6:11578777-11578778(+) m6A 3'UTR       22608085 chr6:11578793-11578794(+) m6A 3'UTR       22608085 chr6:11578801-11578802(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-335-5p	Exosome Serum     18589210 Exosome Saliva     19627513 Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)|Primary dendritic cells     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     25349172 Exosome Blood|Breast milk|Endothelial cells|Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleus Neural progenitor cells     21363885
	TMEM170B	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-335-5p	Tiotixene 941651 Drug resistant 2-trans-n-Buten-1-yl-estradiol 5468334 Drug resistant 2-Methylolivacinium acetate 5458752 Drug sensitive Berberal 5351462 Drug sensitive (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 46907787 Drug resistant 1,3,5-Triazine-2,4-diamine, 1-(3-bromophenyl)-1,6-dihydro-6,6-dimethyl- 407235 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 3,8,13,18,23-Pentaazapentacosane 368998 Drug resistant Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug resistant 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive Ellipticine 3213 Drug sensitive Razoxane 30623 Drug sensitive Acetylstrophanthidin 261075 Drug resistant Capivasertib 25227436 Drug resistant (2-Bromoethyl)triphenylphosphonium bromide 22210408 Drug sensitive 3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug sensitive 19-Formylgeldanamycin-N',N'-pentamethylenehydrazone 135468238 Drug sensitive Triptolid 118701083 Drug resistant 2,9-Dimethylellipticinium acetate 10472068 Drug sensitive 9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug sensitive Bialamicol 10304 Drug resistant crambescidin 800 trihydrochloride - Drug resistant cholestan-5.alpha.-ol-3,6-dione - Drug sensitive naphtho[1,2-c]quinolizinium, 13-methyl-, chloride - Drug sensitive thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug sensitive 2-(4-methylthio-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 2-methylellpticinium - Drug sensitive bengamide g - Drug sensitive pyrazoline derivative - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-335-5p	Curcumin 969516 Drug interaction    RC00004487 Ethanol 702 Drug interaction    RC00004470 Oxaliplatine 6857599 Drug interaction    RC00004489 Bisphenol A 6623 Drug interaction    RC00004476 Vincristine 5978 Drug interaction    RC00004475 Prednisolone 5755 Drug interaction    RC00004474 Eloxatine 5310940 Drug interaction    RC00004488 Imatinib 5291 Drug interaction    RC00004473 Diethylstilbestrol 448537 Drug interaction    RC00004486 Trichostatin A 444732 Drug interaction    RC00004485 Paclitaxel 36314 Drug interaction    RC00004481 5-Fluorouracil 3385 Drug interaction    RC00004472 Doxorubicin 31703 Drug interaction    RC00004480 Daunorubicin 30323 Drug interaction    RC00004479 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004471 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004490 2,3,7,8-Tetrachlorodibenzo-P-dioxin 15625 Drug interaction    RC00004478 Arsenic trioxide 14888 Drug interaction    RC00004477 Flavylium 145858 Drug interaction    RC00004484 Leucovorin 135403648 Drug interaction    RC00004491 Celastrol 122724 Drug interaction    RC00004483 6-Methyl-1,3,8-trichlorodibenzofuran 114900 Drug interaction    RC00004482 Asparaginase Escherichia coli - Drug interaction    RC00004492 Neomycin - Drug interaction    RC00004493 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004494 Interleukin 13 (IL-13) - Drug interaction    RC00004495 Chemotherapy - Drug interaction    RC00008862

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-335-5p	Tamoxifen 2733526       28008602

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-335-5p
Interactor2: TMEM170B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.